Unc Lineberger Comprehensive Cancer Center

This study looks at whether adding tools like a goal planner, personalized texts, or health coach sessions helps adults follow their diet goals better in a 6-month mobile weight loss program. About 580 overweight or obese adults will take part. The goal is to find the best combin…

This study tests whether a self-applied cream (5-fluorouracil) can help clear HPV after a standard procedure (thermal ablation) in women with HIV in Kenya. About 140 women will use either the cream or a placebo every other week for 6 months. The goal is to see if the cream improv…

This study looks at whether people with chronic lymphocytic leukemia (CLL) who have been in remission for at least two years can safely stop taking their BTK inhibitor medication. Researchers will track how long patients stay cancer-free without treatment, and whether quality of …

This study tests a combination of two drugs (XL-092 and pembrolizumab) given before surgery to people with a type of mouth cancer that is not linked to HPV. The goal is to see if this treatment can shrink or eliminate the tumor before it is removed. About 26 adults with early-sta…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will either receive tirzepatide or standard care for 4 weeks before their…

This study looks at whether an online support platform can improve emotional well-being and quality of life for men who had testicular cancer. About 360 men in North Carolina will be split into two groups: one gets the virtual support platform, the other gets educational material…

This study looks at how much mental effort doctors put into writing case reports about rare tumors. It tests whether an AI tool can lighten that load. Ten physicians, medical students, or postdocs will write two case reports—one with AI help and one without—in a single 2-hour ses…

This study aims to see if a program using local community health workers and at-home HPV self-test kits can make cervical cancer screening easier for women in a rural North Carolina county. About 112 women aged 30-64 who are overdue for screening will be invited to participate. T…

This study looks at whether offering colorectal cancer screening kits at local pharmacies can increase the number of people who get screened. About 1,500 patients and pharmacy staff in North Carolina and the Pacific Northwest will take part. The goal is to see if this approach is…

This study looks at ways to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore if allowing women t…

This study tests an online tool called Let's Talk to help people with Lynch syndrome encourage their relatives to get screened for cancer risk. Researchers will work with 20 participants (15 patients and 5 genetic counselors) to see if the tool is easy to use and improves knowled…

This study tests an artificial intelligence tool that helps doctors and physicists review radiation treatment plans for prostate cancer before patients start therapy. The AI highlights differences in how providers plan treatments and points out warning signs to look for, aiming t…

This study looks at whether showing patients a short educational video before they sign consent for a complex pancreas surgery (Whipple procedure) helps them understand the operation better and feel more satisfied. About 60 adults with pancreas cancer will be split into two group…

This study looks at whether wearable health trackers (like a Fitbit) can be easily used in a cancer clinic to monitor patients getting chemotherapy and radiation. About 20 adults with cancer will wear a device during their treatment and for 4 weeks after. The goal is to see if pa…