Unc Lineberger Comprehensive Cancer Center

This study tested whether high-intensity interval training (HIIT) before surgery could slow endometrial cancer growth. Thirty women with early-stage endometrial cancer did supervised HIIT sessions before their planned hysterectomy. Researchers measured changes in a cancer growth …

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (gemcitabine and cisplatin) could shrink tumors more effectively before bladder cancer surgery. 39 adults with muscle-invasive bladder cancer received the combination before …

This study tested whether artesunate vaginal inserts, a medicine used for malaria, can help clear HPV after standard cervical precancer treatment in women living with HIV. 120 women used the inserts or a placebo for 5 days on, 1 week off, repeated 3 times. The goal was to see if …

This study tested a three-step treatment for head and neck cancer: chemotherapy before surgery, then surgery, followed by more chemo and radiation based on risk. The goal was to see if this approach could reduce side effects and improve how well the treatment works. 40 adults wit…

This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is acceptable and helpful for treating cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it accep…

This study tested whether adding denosumab (a bone-strengthening drug) to standard immunotherapy (pembrolizumab or nivolumab) could help control advanced melanoma. 25 adults with stage III or IV melanoma that could not be removed by surgery took part. The goal was to see if denos…

This study tested a new treatment for a rare type of testicular cancer called nonseminomatous germ cell tumors. Researchers took patients' own immune cells (T cells) and modified them to recognize and attack cancer cells that carry a protein called CD30. The goal was to see if th…

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 adults with a specific type of metastatic colon cancer (KRAS/NRAS/BRAF wild-type). The goal was to see if the combination could shrink or stop tumor growth. The study is complete, and results will help…

This study looked at whether stronger warning labels on little cigars and cigarillos (LCCs) can discourage young people from using them. Researchers surveyed 928 teens and young adults (ages 15-20) who either currently use LCCs, have tried them, or are open to trying them. The go…

This study tested two methods to help doctors talk about the HPV vaccine with families. Some clinics got training from an outside expert, while others learned from a vaccine champion within their own healthcare system. The goal was to see which approach led to more children ages …

This study tested whether mailing a simple stool test (FIT) to people's homes could increase colorectal cancer screening rates. Over 4,300 adults aged 45-75 who were at average risk took part. The goal was to make screening easier and catch cancer earlier, especially in underserv…

This study tested a financial navigation program to help cancer patients in rural and non-rural North Carolina deal with the high costs of care. 258 adults with cancer and significant financial distress took part. The program aimed to reduce financial toxicity and improve quality…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight and be more active. The app tracked diet, weight, and exercise as part of a behavioral program. The goal was to see if this approach is practical and liked by participants. It focused…

This study looked at how often people with chronic lymphocytic leukemia or multiple myeloma face money problems because of their treatment. About 218 patients and their doctors answered surveys about costs and available help. The goal was to measure how common financial difficult…

This study aimed to find which ads work best to encourage people who smoke menthol cigarettes to quit. Over 1,200 US adults aged 21 and older who smoke menthols rated different ads online. Researchers measured how motivating and convincing each ad was to help identify the most ef…

This study looked at women aged 70 and older who finished treatment for early-stage breast cancer within the past two months. Researchers used a special survey to find symptoms and problems the women were having, then shared this information with their doctors to arrange extra he…

This study looked at how different warning labels on little cigars and cigarillos (LCCs) affect what people notice and how they feel. Researchers used eye-tracking technology and skin sensors to measure attention and emotional reactions in 90 adult LCC users. The goal was to see …

This small pilot study looked at whether DNA from cancer cells (called ctDNA) can be detected in the blood or urine of people with muscle-invasive bladder cancer who are receiving a combination of surgery, radiation, and chemotherapy. The goal was to see if collecting and measuri…

This study tested a mobile program designed to help young adult cancer survivors (ages 18-39) eat healthier and exercise more. Researchers wanted to see if the program was easy to use and if participants liked it. The study involved 72 survivors and focused on whether people woul…

This study tested a mobile health app designed to help Black or African American women with breast cancer learn about and join clinical trials. Researchers wanted to see if the app was easy to use and helpful for both patients and clinic staff. The study involved 80 women and foc…

This study looked at whether putting warning labels on e-cigarette devices helps people want to quit vaping. Over 1,300 adult vapers had their devices labeled with either a control message, a text warning, or a picture warning. Researchers then measured their desire to quit over …

This study looked at whether it's possible to regularly measure muscle mass and physical abilities in children (ages 8-21) with newly diagnosed cancer. Researchers used simple tests like walking and grip strength, along with special scans, to track changes during treatment. The g…

This study looked at whether different social media designs make people more likely to flag false cancer information. 294 US adults who had cancer or cared for someone with cancer took part. They were shown posts and asked if they would flag or dislike them. The goal was to learn…

This study looked at whether adding physical and occupational therapy consultations for adults admitted for a bone marrow transplant could improve outcomes. Researchers compared patients who received therapy with historical data to see if it reduced hospital stays, readmissions, …