Unc Lineberger Comprehensive Cancer Center

This study looks at whether giving clinics financial rewards can improve how they talk about and give the HPV vaccine. About 34 clinics in North Carolina will either get communication training alone or training plus a financial incentive program. The goal is to see if these rewar…

This study tests whether the drug rituximab is safe and effective for treating multicentric Castleman disease (MCD) in Malawi. About 15 adults with MCD will receive rituximab, and researchers will track side effects and survival. The goal is to see if rituximab works better and c…

This early-phase study tests a new treatment for people with multiple myeloma that has returned or not responded to standard therapy. The treatment uses a patient's own immune cells (T cells) that are modified in a lab to recognize and attack myeloma cells carrying a protein call…

This early-phase trial tests a personalized vaccine (PANDA-VAC) made from a patient's own tumor mutations, given alongside the immunotherapy drug pembrolizumab. The study includes up to 6 adults with advanced squamous lung or head/neck cancer that cannot be cured. The main goal i…

This study tests a combination of two chemotherapy drugs and an immunotherapy drug given before surgery to people with advanced head and neck cancer that can be removed. The goal is to shrink or kill the cancer enough so that patients may not need radiation after surgery, which c…

This study tests whether giving two drugs, pembrolizumab and olaparib, before and after standard chemoradiation can help people with advanced head and neck cancer. About 45 adults will take part. The goal is to see if this approach delays cancer growth or improves survival.

This study tests a new treatment for people with Hodgkin or non-Hodgkin lymphoma that has come back or not responded to other therapies. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells carrying a protein …

This early-phase study tests a new treatment for people with certain types of lymphoma that have not responded to standard therapy or have returned. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells, plus a…

This study tests a less intense version of a standard four-drug combination (Dara-RVd) for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. The goal is to see if giving one of the drugs (bortezomib) once a week instead of twice a week stil…

This early-phase study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. The T-cells are modified to target cancer cells and include a safety switch that can be turned on to reduce severe side effects. The goa…

This early-stage trial tests a new treatment for women whose ovarian cancer has come back. The therapy uses the patient's own immune cells, modified to target a protein called B7-H3 on cancer cells. The main goal is to find a safe dose and check for side effects in up to 21 parti…

This study tests a combination of three drugs (isatuximab, pomalidomide, and dexamethasone) at lower-than-standard doses in people with multiple myeloma that has returned or not responded to treatment. The goal is to see if this gentler approach is safe and effective for patients…

This study tests a new treatment for people with a hard-to-treat type of leukemia. The treatment uses the patient's own immune cells (T cells) that are modified to better find and kill cancer cells. A safety switch is added to turn the cells off if severe side effects occur. The …

This study tests whether giving a PD-1 inhibitor drug after CAR-T cell therapy can help control Hodgkin lymphoma that has come back or not responded to other treatments. Ten adults with this type of lymphoma will receive the combination to see if it improves response rates. The g…

This study tests whether a digital program (mPATH-Cloud) helps more people complete colorectal cancer screening compared to usual care. About 1,000 adults aged 45-73 who are overdue for screening take part. The program sends a text or letter inviting them to a website where they …

This study looks at ways to help primary care clinics give more HPV vaccines to children ages 9-12. Some clinics get communication training, while others also get tools to use their existing vaccine standing orders. The goal is to see if these steps increase the number of kids wh…

This study tests whether a liver cancer treatment called Y90 radioembolization can be safely done in one day instead of two for people with small tumors (less than 5 cm). The usual two-day process includes a mapping step that may not be needed for these patients. The goal is to s…

This study tests whether a specially designed physical activity program can help African American colorectal cancer survivors become more active. About 21 participants will use a Fitbit tracker and watch exercise videos to see if the program is practical and effective. The goal i…

This study was designed to see if using MRI scans to guide radiation therapy can better protect the salivary ducts and reduce dry mouth in people with oropharynx cancer. Dry mouth is a common and lasting side effect of radiation. The plan was to compare patient-reported dry mouth…

This study was designed to see if a diet low in two amino acids (cysteine and methionine) could change the body's chemistry in people with recurrent brain tumors. It planned to enroll up to 30 participants and compare the special diet to a regular diet before standard treatments …

This study was designed to track immune system recovery and test a pneumococcal vaccine (PCV-21) in people receiving CAR-T therapy for blood cancers or solid tumors. Participants would have had regular clinic visits and blood tests for up to 24 months. However, the study was with…

This study looks at how two drugs, pembrolizumab and entinostat, change the immune system in people with muscle-invasive bladder cancer who cannot have standard chemotherapy. About 20 participants receive the drugs before their scheduled bladder removal surgery. The goal is to me…

This study is observing 127 people with HIV-related Kaposi sarcoma in Malawi and South Africa to see how their cancer responds to standard chemotherapy. Researchers want to find out why some patients do better than others, based on factors like gender and virus levels. The goal i…

This study aims to see if it's possible to use electronic questionnaires to track symptoms in 100 gynecologic cancer patients before, during, and after radiation therapy. Participants will complete surveys at various time points up to two years after treatment. The main goal is t…

This study looks at whether having patients report their side effects through weekly surveys can help doctors better manage treatment for advanced kidney cancer. About 42 adults taking oral chemotherapy pills will answer questions about symptoms like nausea and fatigue. Their car…

This study collects medical information and biological samples from 32 cancer patients starting or restarting immunotherapy. The goal is to better understand why some patients develop immune-related side effects and how to manage them. Researchers hope this knowledge will improve…

This study aimed to see if a special PET/MRI scan could predict which women with early endometrial cancer or a precancerous condition would respond to hormone therapy. It planned to enroll 8 women who would get one scan and be followed for 6 months. However, the study was withdra…

This study follows women who are cancer-free at least three years after finishing early breast cancer treatment. Researchers want to learn how things like the type of cancer, treatments received, and side effects during treatment may affect quality of life and daily function year…