Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This study is testing whether a drug called tenecteplase can help people who have had a stroke and recently took blood thinners (DOACs). The drug is given as a single injection to break up blood clots. About 912 participants will be randomly assigned to receive either tenecteplas…

This study tests whether the drug Hetrombopag can safely raise platelet counts in breast cancer patients who developed low platelets (thrombocytopenia) after T-DM1 treatment. About 56 participants will take Hetrombopag tablets daily for two weeks per cycle. The goal is to see if …

This phase III trial tests whether adding ribociclib to standard hormone therapy (aromatase inhibitor) can prevent breast cancer from coming back in women with hormone receptor-positive, HER2-negative early breast cancer who still have cancer after initial chemotherapy. About 446…

This study tests whether adding tofacitinib to standard methotrexate works better than methotrexate alone for people with active rheumatoid arthritis who have a specific 'myeloid-stromal' type. 130 adults will be randomly assigned to either the combo or methotrexate-only group fo…

This phase II trial is testing whether adding an immunotherapy drug (PD-1 antibody) to standard chemotherapy (GEMOX) after surgery can help prevent cancer from returning in people with perihilar cholangiocarcinoma that has spread to nearby lymph nodes. The study plans to enroll 6…

This phase 2 trial is testing a combination of three drugs—adebrelimab (immunotherapy), apatinib (targeted therapy), and tegafur (chemotherapy)—in 32 people with advanced esophageal cancer that stopped responding to initial immunotherapy plus chemotherapy. The main goal is to see…

This early-phase trial is testing a new treatment for people with advanced mesenchymal malignancies (a group of rare cancers including sarcomas). The treatment uses the patient's own immune T cells, which are modified in a lab to recognize and attack cancer cells that carry a pro…

This study is tracking 300 people with HER2-positive or HER2-low breast cancer who are receiving trastuzumab-rezetecan as part of their routine care. Researchers are monitoring side effects and how well the drug works in real-world conditions, not in a strict lab setting. The goa…

This Phase 3 trial tests whether a combination of three drugs—camrelizumab, apatinib, and eribulin—works better than standard chemotherapy for people with advanced triple-negative breast cancer. The study plans to enroll 246 participants and will measure how long the cancer stays…

This study tests whether adding a clot-dissolving medicine directly into the brain's arteries during standard clot-removal procedures helps people recover better after a stroke caused by a medium-sized blockage. About 530 adults with acute ischemic stroke will be randomly assigne…

This study compares two surgical approaches for papillary thyroid cancer that has spread to lymph nodes in the neck: robotic surgery through the armpit versus traditional open surgery. The goal is to see if the robotic method offers similar cancer control and survival rates while…

This phase 2 trial tests a new treatment plan for people with a certain type of advanced breast cancer (HR-positive, HER2-low or ultra-low). Participants first receive trastuzumab rezetecan alone for several months, then switch to a combination of CDK4/6 inhibitors and hormone th…

This study is testing whether a genetic test called RecurIndex can identify breast cancer patients with cancer in their lymph nodes who are at low risk of recurrence. If the test shows high risk, patients will receive extra radiation to the lymph nodes; if low risk, they may avoi…

This study looks at whether giving immunotherapy less often (extended dose intervals) works as well as the standard schedule for people with advanced triple-negative breast cancer. The goal is to keep the cancer under control while reducing side effects and improving quality of l…

This study tests whether taking an oral chemotherapy (paclitaxel) along with a fixed-dose injection of two targeted drugs (pertuzumab and trastuzumab) can eliminate all signs of HER2-positive breast cancer before surgery. About 112 adults with early-stage HER2+ breast cancer will…

This study tests whether adding adalimumab to standard chemotherapy and radiation before surgery can help eliminate esophageal cancer more effectively. About 37 adults with resectable esophageal squamous cell carcinoma will receive this combination. The main goal is to see how ma…

This study tests a combination of two drugs (apatinib and adebrelimab) plus chemotherapy (GEMOX) as a first treatment for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that cannot be removed by surgery. The goal is to see if this mix shrinks tum…

This study tests whether a different combination of targeted drugs (trastuzumab plus neratinib) works better than the standard combo (trastuzumab plus pertuzumab) for women with a certain type of breast cancer (HER2-positive, hormone receptor-positive) who still have small amount…

This study looks at whether adding hydroxychloroquine to standard levothyroxine treatment can increase the chance of a live birth in women with thyroid antibodies who have had two or more unexplained miscarriages. About 800 women will receive either the combination or levothyroxi…

This early-stage study is testing a personalized cell therapy for people with advanced pancreatic cancer that has not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells with a specific KRAS mutation. The …

This study tests two different ways to give chemotherapy combined with immunotherapy and a targeted drug for people with advanced liver cancer (BCLC stage C). One group gets standard IV chemo plus the drugs camrelizumab and apatinib. The other group gets the same drugs but with c…

This study tests whether adding contrast-enhanced ultrasound to standard ultrasound can improve the diagnosis of thyroid cancer. Researchers are comparing two scoring methods in 800 participants with thyroid nodules. The goal is to see which method better identifies cancer and re…

This study is developing an artificial intelligence (AI) model to detect whether cancer has spread to lymph nodes by analyzing digital images of tissue slides. Researchers will compare the AI's accuracy to that of pathologists in 10,000 cancer patients. The goal is to see if AI c…

This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can predict how much cancer has spread to lymph nodes in patients with early-stage thyroid cancer. Researchers will review past images from 600 patients and compare them to surgical results. I…

This study aims to develop an AI model that combines ultrasound images and cell slide images to more accurately predict cancer risk in thyroid nodules that have uncertain results from a needle biopsy. About 396 patients with these uncertain results will be included. The goal is t…

This study tests whether wearing compression gloves and stockings during chemo, plus acupuncture after, can prevent nerve damage (peripheral neuropathy) in breast cancer patients. About 384 people will be randomly assigned to one of four groups: compression only, acupuncture only…

This study tests whether giving vaginal progesterone gel for a longer time can prevent preterm birth in women who became pregnant through IVF with a fresh embryo transfer. About 100 women aged 20-40 with a single pregnancy will be enrolled. Researchers will compare preterm birth …

This study tests whether taking probiotics can prevent severe diarrhea in women with HER2-positive breast cancer who are treated with neratinib. About 308 participants will be randomly assigned to receive either probiotics or a placebo for six weeks, alongside standard diarrhea p…

This study compares a newer, less invasive mastectomy technique (endoscopic skin-sparing) with the standard approach in 258 women with breast cancer. The goal is to see if the endoscopic method leads to fewer wound complications and higher patient satisfaction. Participants are r…

This study compares two painkiller combinations—dezocine plus sufentanil versus nalbuphine plus sufentanil—for pain relief after oral cancer surgery with flap reconstruction. Sixty adults will receive one of the two combinations through a patient-controlled pump. The goal is to s…

This study looks at whether combining a non-invasive brain stimulation technique called rTMS with hearing aids can improve cognitive function in older adults with age-related hearing loss. About 189 participants, including those with and without hearing aids, will receive two 14-…

This study tests whether a personalized form of brain stimulation (TMS) can better reduce chronic tinnitus (ringing in the ears) than the standard approach. 116 adults with bothersome tinnitus for over 6 months will receive five days of stimulation, with their progress tracked fo…

This study tests if an external oil can reduce severe breast pain in premenopausal women. About 190 women will apply either the oil or a placebo for three menstrual cycles. The main goal is to see if the oil cuts pain by at least half. This is a phase 3 trial, meaning it's in the…

This study compares two treatments for patellar tendinitis (knee pain from overuse). One group gets standard shock wave therapy on the kneecap tendon, while the other gets shock wave therapy plus a special fascial manipulation technique. The goal is to see which approach provides…

This study is developing an artificial intelligence system to help surgeons find and check the blood supply of the parathyroid glands during thyroid surgery. The parathyroid glands are small and hard to see, and damaging them can cause serious side effects. The AI will be trained…

This study tests whether a large language model (AI) can help junior doctors write more accurate and efficient cancer treatment reports. Forty doctors will be split into two groups: one using AI assistance, the other using traditional methods. The reports will be scored by expert…

This study is for women with a certain type of breast cancer that is hormone-sensitive and has spread to 1-3 lymph nodes. Researchers want to see if it is safe to skip radiation therapy to the lymph nodes for those with a low-risk genetic test result. The study will follow 635 pa…

This observational study looks at 255 women with HER2-low breast cancer to understand how certain gene changes (HRD/HRR) relate to survival. Researchers will analyze tumor and blood samples to map these genetic features. The goal is to learn more about this cancer type, not to te…