Promising combo aims to wipe out esophageal cancer before surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- 1. Provided informed consent and sign the informed consent form; * 2\. Male or female, Aged 18-75 years (counted on the date of signing informed consent); * 3\. Pathological confirmed ESCC; * 4\. Patients assessed by thoracic oncologists as resectable without distant metastasis * 5\. Patients evaluate with clinical staging of T1-4aN1-3M0 or T3-4aN0M0(AJCC 9.0) based on imaging and pathological examination results; * 6\. Have at least one assessable lesion according to the RECIST V1.1 * 7\. ECOG-PS score: 0-1; * 8\. Patients with normal function of organs such as heart, brain, lungs, and kidneys who can tolerate surgery; * 9\. With a life expectancy of ≥ 6 weeks; * 10\. Adequate major organ function without severe hematologic, cardiac, pulmonary, hepatic, renal, or bone marrow dysfunction, and no immunodeficiency disease; Exclusion Criteria: * 1\. Patients who have received or are currently receiving chemotherapy, radiotherapy, immunotherapy, or targeted therapy * 2\. Patients with distant metastasis or inability to undergo resection after evaluation by thoracic surgeons * 3\. Simultaneously developing tumors in other parts of the body * 4\. Severe impairment of heart, liver, and kidney function (heart function grade 3-4, ALT and/or AST exceeding the upper limit of normal by more than 1.5 times, Cr (serum creatinine) exceeding the upper limit of normal by more than 1.5 times) * 5\. Patients with a history of autoimmune diseases who were receiving immunosuppressive therapy prior to enrollment, with immunosuppressive doses\>10 mg/day or oral prednisone for more than 2 weeks * 6\. Severe allergy to immune preparations * 7\. Abnormal coagulation function: (PT\>16s, APTT\>53s, TT\>21s, Fib\<1.5 g/L), bleeding tendency or during thrombolytic or anticoagulant therapy * 8\. Pregnancy or lactation period * 9\. Other situations as judged by investigators not suitable for inclusion.;