Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This early-phase study tests a personalized cell therapy for people with advanced mesenchymal cancers (like certain sarcomas) that have stopped responding to standard treatments. Researchers take a patient's own immune cells, engineer them to recognize a protein called MAGE-A4 fo…

This study tests a two-step treatment plan for people with advanced breast cancer that is hormone-receptor-positive and HER2-low or ultra-low. First, participants receive a targeted drug called trastuzumab rezetecan for several months. Then, they switch to a combination of a CDK4…

This study tests whether adding adalimumab to standard chemotherapy and radiation before surgery can help eliminate esophageal cancer more effectively. About 37 adults with resectable esophageal squamous cell carcinoma will receive this combination. The main goal is to see how ma…

This study looks at 130 adults with active rheumatoid arthritis who have a specific joint tissue type (myeloid-stromal) that often leads to worse outcomes. Half will get standard methotrexate alone, and the other half will get methotrexate plus tofacitinib, a targeted pill. The g…

This study looks at whether the drug T-DM1 can be used safely and effectively in breast cancer patients who have developed low platelet counts (thrombocytopenia) from prior chemotherapy. It will enroll 56 adults whose platelet levels have returned to normal before starting T-DM1.…

This study tests a three-drug combination (adebrelimab, apatinib, and tegafur) in 32 adults with advanced esophageal cancer that worsened after standard immunotherapy plus chemotherapy. The goal is to see if this new mix can shrink tumors or slow the disease. Participants must be…

This study looks at whether a treatment called rTMS (a gentle brain stimulation) combined with hearing aids can help older adults with age-related hearing loss think more clearly. About 189 people aged 50-85 will join, including those who already use hearing aids and those who do…

This study tests a combination of two drugs (apatinib and adebrelimab) plus chemotherapy (GEMOX) as a first treatment for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that cannot be removed by surgery. The goal is to see if this mix shrinks tum…

This study tests whether a different combination of targeted drugs (trastuzumab plus neratinib) works better than the standard combo (trastuzumab plus pertuzumab) for women with a certain type of breast cancer (HER2-positive, hormone receptor-positive) who still have small amount…

This study tests whether adding a clot-dissolving medicine directly into the brain's arteries during standard stroke treatment helps people recover better after a stroke caused by a medium-sized blockage. About 530 adults with acute ischemic stroke will be randomly assigned to ge…

This study is looking at how well a drug called trastuzumab-rezetecan works and how safe it is for people with HER2-positive or HER2-low breast cancer. About 300 patients will take part, and their doctors will decide the exact treatment plan. The goal is to see if the drug helps …

This study looks at whether adding hydroxychloroquine to standard levothyroxine treatment can increase the chance of a live birth in women with thyroid antibodies who have had two or more unexplained miscarriages. About 800 women will receive either the combination or levothyroxi…

This early-stage study is testing a personalized cell therapy for people with advanced pancreatic cancer that has not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells with a specific KRAS mutation. The …

This study tests whether adding ribociclib to standard hormone therapy can help prevent breast cancer from returning in people with hormone receptor-positive, HER2-negative early breast cancer who still have cancer after initial chemotherapy. About 446 participants will be random…

This study is for people with early-stage breast cancer that has spread to a few lymph nodes. It uses a genetic test called RecurIndex to see who can safely skip radiation to the lymph nodes, reducing side effects. About 540 participants will be randomly assigned to receive or sk…

This study tests whether adding an immunotherapy drug (PD-1 antibody) to standard chemotherapy (GEMOX) after surgery can help prevent bile duct cancer from coming back in patients whose cancer had spread to nearby lymph nodes. The trial enrolls 62 adults aged 18-75 with good perf…

This study tests two different ways to give chemotherapy combined with immunotherapy and a targeted drug for people with advanced liver cancer (BCLC stage C). One group gets standard IV chemo plus the drugs camrelizumab and apatinib. The other group gets the same drugs but with c…

This study tests a new treatment for HER2-positive breast cancer that uses an oral chemotherapy pill (paclitaxel) plus a fixed-dose injection of two targeted drugs (pertuzumab and trastuzumab) before surgery. The goal is to see if this combination can completely eliminate cancer …

This study compares a newer robotic surgery done through the armpit to standard open neck surgery for people with papillary thyroid cancer that has spread to lymph nodes in the side of the neck. The goal is to see if the robotic method is as safe and effective at controlling canc…

This study is for people with advanced triple-negative breast cancer whose disease is under control after initial immunotherapy treatment. It compares the usual dosing schedule of immunotherapy to a schedule with longer breaks between doses. The goal is to see if the extended sch…

This study tests whether a drug called tenecteplase can help people having a stroke who recently took blood thinners (DOACs). About 912 participants will receive either the drug or a placebo to see if it improves their recovery and ability to function after 90 days. The goal is t…

This phase 3 trial tests whether a combination of three drugs (camrelizumab, apatinib, and eribulin) works better than standard chemotherapy for people with advanced triple-negative breast cancer. The study involves 246 participants and will measure how long the cancer stays unde…

This study tests whether adding contrast-enhanced ultrasound to standard ultrasound can more accurately tell if a thyroid nodule is cancerous. Researchers will compare two different scoring methods in 800 adults with thyroid nodules. The goal is to improve diagnosis and reduce th…

This study aims to develop and test an artificial intelligence (AI) model that can detect whether cancer has spread to lymph nodes by analyzing digital images of tissue samples. Researchers will compare the AI's accuracy to standard pathology reports from doctors. The goal is to …

This study aims to develop an AI model that combines ultrasound images and cell slide images to more accurately predict cancer risk in thyroid nodules that have uncertain results from a needle biopsy. About 396 patients with these uncertain results will be included. The goal is t…

This study is developing an artificial intelligence system to help surgeons locate and check the blood supply of parathyroid glands during thyroid surgery. The parathyroid glands are small and hard to see, and damaging them can cause low calcium levels. The AI will be trained on …

This study tests whether acupuncture, compression therapy, or both can prevent nerve damage (peripheral neuropathy) caused by taxane chemotherapy in breast cancer patients. About 384 people with early-stage breast cancer will be randomly assigned to one of four groups. The goal i…

This study compares a newer, less invasive mastectomy technique (endoscopic skin-sparing mastectomy) with the standard mastectomy in 258 women with breast cancer. The goal is to see if the newer method leads to fewer wound complications and higher patient satisfaction. Participan…

This study tests if an external oil can reduce severe breast pain in premenopausal women. About 190 women will use either the oil or a placebo for three menstrual cycles. The goal is to see if the oil provides meaningful pain relief without side effects.

This study tests two different pain medicines (dezocine or nalbuphine) given with a standard opioid after oral cancer surgery involving flap reconstruction. The goal is to see which combination provides better pain relief with fewer side effects, and whether it helps the surgical…

This study compares two treatments for patellar tendinitis (knee pain from overuse). One group gets standard shock wave therapy on the kneecap tendon, while the other gets shock wave therapy plus a special fascial manipulation technique. The goal is to see which approach provides…

This study tests whether taking probiotics can help prevent severe diarrhea caused by the breast cancer drug Neratinib. About 308 women with HER2-positive breast cancer will be randomly assigned to receive either probiotics or a placebo alongside standard diarrhea prevention. The…

This study tests whether a personalized form of brain stimulation (TMS) can better reduce the ringing or buzzing of chronic tinnitus compared to standard TMS. About 116 adults with tinnitus lasting over 6 months will receive either personalized or standard TMS for 5 days. Researc…

This study tests whether a large language model (AI) can help junior doctors write more accurate and efficient cancer treatment reports. Forty doctors will be split into two groups: one using AI assistance, the other using traditional methods. The reports will be scored by expert…

This study is for women with a certain type of breast cancer that is hormone-sensitive and has spread to 1-3 lymph nodes. Researchers want to see if it is safe to skip radiation therapy to the lymph nodes for those with a low-risk genetic test result. The study will follow 635 pa…

This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can better predict how much cancer has spread to lymph nodes in people with early-stage thyroid cancer. Researchers will review medical records and ultrasound images from 600 patients to build…

This observational study looks at 255 women with HER2-low breast cancer to understand how certain gene changes (HRD/HRR) relate to survival. Researchers will analyze tumor and blood samples to map these genetic features. The goal is to learn more about this cancer type, not to te…

This study looks at 57 women with mild non-lactational mastitis (breast inflammation not related to breastfeeding) to see how often the condition gets worse when no treatment is given. Participants will be watched for up to 24 weeks, and doctors will track which factors might lea…