Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This study is for breast cancer patients who developed low platelet counts (thrombocytopenia) after previous chemotherapy. It tests whether the drug T-DM1 can be given safely while keeping platelet levels in a safe range. About 56 adults aged 18-75 will participate. The goal is t…

This study tests whether adding ribociclib to standard hormone therapy helps prevent breast cancer from returning in people with hormone receptor-positive, HER2-negative early breast cancer who still have cancer cells after chemotherapy. About 446 participants will be randomly as…

This study tests a two-step treatment plan for people with a certain type of advanced breast cancer (HR+/HER2-low). First, they receive a drug called trastuzumab rezetecan for several months. Then, they switch to a combination of a CDK4/6 inhibitor and hormone therapy. The goal i…

This early-phase study tests a personalized cell therapy for people with advanced pancreatic cancer that has not responded to standard treatments. The therapy uses the patient's own immune cells, modified to recognize and attack cancer cells with a specific KRAS mutation. The stu…

This study compares a newer robotic surgery (through the armpit) to traditional open neck surgery for people with papillary thyroid cancer that has spread to neck lymph nodes. About 876 adults aged 18-70 will be randomly assigned to one of the two procedures. The goal is to see i…

This study tests whether adding an immunotherapy drug (PD-1 antibody) to standard chemotherapy (gemcitabine and oxaliplatin) after surgery can help prevent bile duct cancer from returning in patients whose cancer had spread to nearby lymph nodes. About 62 adults aged 18-75 with g…

This study tests a combination of two drugs (apatinib and adebrelimab) plus chemotherapy (GEMOX) as a first treatment for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer) that cannot be removed by surgery. The goal is to see if this combination sh…

This study tests whether a different combination of targeted drugs (trastuzumab plus neratinib) works better than the standard combo (trastuzumab plus pertuzumab) for women with a certain type of breast cancer (HER2-positive, hormone receptor-positive) who still have small amount…

This study tests whether the clot-busting drug tenecteplase can help people having a stroke who recently took a direct oral anticoagulant (DOAC) blood thinner. About 912 adults will receive either tenecteplase or a placebo to see if it improves their ability to function independe…

This study tests whether a stronger treatment (methotrexate plus tofacitinib) works better than methotrexate alone for people with active rheumatoid arthritis who have a specific type of joint inflammation called myeloid-stromal. About 130 adults will take part for 12 weeks, with…

This study tests whether adding a clot-dissolving drug directly into the brain's arteries during standard clot removal helps people recover better after a medium-sized stroke. About 530 adults with acute ischemic stroke will be randomly assigned to get the drug plus standard care…

This study tests two different ways to give a combination of chemotherapy and immunotherapy drugs to people with advanced liver cancer (BCLC stage C). One method uses a standard IV drip, while the other delivers the chemo directly to the liver through a catheter. The goal is to s…

This study looks at 600 people with early-stage thyroid cancer to see if a special ultrasound can better predict whether the cancer has spread to nearby lymph nodes. Knowing the amount of spread helps doctors choose the right treatment, from less to more surgery. The goal is to i…

This study aims to create an AI tool that combines ultrasound images and cell slide pictures to more accurately predict cancer risk in thyroid nodules that have unclear results from a standard needle test. About 396 people with these uncertain nodules will be included. The goal i…

This study aims to develop an artificial intelligence (AI) model that can automatically detect whether cancer has spread to lymph nodes by analyzing digital images of tissue samples. Researchers will compare the AI's accuracy to that of pathologists in 10,000 cancer patients. If …

This study tests whether adding a special fascial therapy to standard shock wave treatment works better for patellar tendinitis (jumper's knee). About 38 adults with knee pain will be split into two groups: one gets the combined therapy, the other gets shock waves alone. Research…

This study tests whether taking probiotics can reduce severe diarrhea caused by the breast cancer drug neratinib. About 308 women with HER2-positive breast cancer will be randomly assigned to receive either probiotics or a placebo, along with standard diarrhea prevention medicati…

This study compares a newer, less invasive mastectomy (endoscopic skin-sparing) with standard mastectomy in 258 women with breast cancer. The goal is to see if the newer method leads to fewer wound problems and higher patient satisfaction. Participants must have small to medium b…

This study tests whether an external oil can reduce severe breast pain in premenopausal women better than a placebo. About 190 women with long-lasting, severe breast pain will apply the oil or a placebo daily for three menstrual cycles. Researchers will measure pain relief using …

This study looks at whether women with a specific type of breast cancer can safely avoid radiation therapy to the lymph nodes. The participants have hormone-sensitive, HER2-negative tumors with 1-3 positive lymph nodes and a low RecurIndex score. The goal is to see if skipping th…