Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This study tests a drug called sacituzumab in 22 people with a rare and aggressive ovarian cancer (clear cell carcinoma) whose tumors grew after immunotherapy. The drug targets a protein on cancer cells to deliver chemotherapy directly, aiming to shrink tumors and control the dis…

This study tests whether a new drug, trastuzumab rezetecan, works as well as or better than the current drug trastuzumab deruxtecan for women with advanced HER2-positive breast cancer that has worsened after previous treatment. About 100 women will be randomly assigned to one of …

This study tests a new mRNA vaccine designed to help the immune system attack cancer cells. The vaccine targets a protein found only in tumors and is given together with an immunotherapy drug (anti-PD-1). About 60 adults with advanced solid tumors that cannot be removed by surger…

This study tests whether giving the steroid methylprednisolone along with a standard clot-removal procedure helps people recover better after a severe stroke caused by a large blockage. About 912 adults aged 18-85 with acute ischemic stroke will be randomly assigned to receive ei…

This study tests a triple-combination inhaler (budesonide/glycopyrronium/formoterol) in 23 smokers aged 40-75 with PRISm, a lung condition that often leads to COPD. Participants will use the inhaler for 12 weeks to see if it improves lung function, symptoms, and quality of life. …

This study tests a combination of three drugs (inavolisib, ribociclib, and fulvestrant) as a first treatment for Chinese women with a specific type of advanced breast cancer that has a PIK3CA gene mutation. The goal is to see if this combination can slow down or stop the cancer f…

This study tests a drug called tocilizumab in 31 women aged 20-50 with a rare, painful breast inflammation that doesn't get better with steroids or causes bad side effects. The drug blocks a protein involved in inflammation. The main goal is to see if it can calm the inflammation…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This study looks at whether removing keloids surgically and then applying a radioactive patch (32P) can prevent them from returning. About 401 people with keloids will get this treatment and be checked every 6 months for 2 years. The goal is to see how well the combo works and wh…

This study tests if blocking a key liver artery before surgery can help remove advanced bile duct cancer that is normally considered inoperable. The procedure aims to grow new blood vessels to keep the liver healthy after the cancer-involved artery is removed. The trial will enro…

This study tests a pill called hetrombopag to treat low platelet counts caused by chemotherapy in women with gynecological cancers like ovarian or cervical cancer. About 244 participants will receive the drug to see if it can safely raise platelets enough to avoid treatment delay…

This study tests whether a new two-drug combination (sacituzumab govitecan plus toripalimab) works better than a standard combination (toripalimab plus nab-paclitaxel) for people with advanced triple-negative breast cancer that has not been treated before. About 150 adults with P…

This study tests a combination of three drugs—liposomal irinotecan, sintilimab, and anlotinib—in people whose ovarian clear cell carcinoma has come back or not gone away after standard treatment. The goal is to see if this mix can shrink tumors and control the disease. About 36 a…

This study compares a single chemotherapy drug (paclitaxel) to the standard two-drug combo (paclitaxel plus carboplatin) as initial treatment before surgery for advanced ovarian cancer. It is for patients whose tumors have high levels of a protein called PARK2, which may make the…

This study tests three different doses of the drug famitinib combined with camrelizumab in 120 people with recurrent or metastatic cervical cancer that cannot be cured by standard treatments. The goal is to find a dose that keeps the cancer under control while causing fewer sever…

This study looks at whether a special ultrasound can accurately detect if breast cancer has completely disappeared from lymph nodes after chemotherapy. About 150 women with cancer that spread to their lymph nodes will have a small clip placed in a cancerous node before treatment.…

This study tests an artificial intelligence (AI) tool that uses prostate biopsy images to predict how long hormone therapy will work before the cancer becomes resistant. Researchers will enroll 150 men with intermediate- to high-risk prostate cancer who are starting hormone thera…

This study tests a surgical technique to prevent arm swelling (lymphedema) in breast cancer patients at high risk. During standard breast cancer surgery, doctors will move a small piece of tissue from the chest wall to the armpit to help fluid drain properly. 100 women with a hig…

This study compares two ways of giving a large-volume injection under the skin for breast cancer treatment: one using a machine that delivers the medicine at a steady speed, and the other done by a nurse by hand. The goal is to see which method causes less pain. Forty women with …

This study tests if a new treatment—mild nerve stimulation on the ear plus personalized music—can reduce the annoyance of chronic tinnitus (ringing in the ears) better than standard therapy. About 386 adults with bothersome tinnitus for at least 6 months will be randomly assigned…

This study tests whether artificial intelligence can give an early warning when a cancer might spread to other parts of the body. Researchers will follow 10,000 adults with cancer but no current signs of spread, using routine scans and patient data to see if the AI model can pred…

This study will watch 3,000 stroke patients in China who receive clot-busting medicine more than 4.5 hours after their stroke started. Researchers want to see if this later treatment helps patients recover better and is safe in everyday hospital care. The study does not test a ne…

This study looks at whether a color Doppler ultrasound feature called the 'twinkling artifact' can make breast tissue marker clips easier to see. These clips are placed to mark suspicious areas in the breast or lymph nodes. The study will review past images from about 86 women wi…

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study looks back at medical records of 5000 people with various cancers that have spread to lymph nodes, all treated with immunotherapy. Researchers want to see how often the lymph node tumors shrink and what factors, like taking beta-blockers, might affect results. The goal…

This study tests whether a new method called NICS-AI, which analyzes fluid from the embryo's growth dish and uses artificial intelligence, can better select the best embryo for transfer compared to standard visual inspection. The trial involves 520 women aged 35-43 or with a hist…