New ultrasound model may guide thyroid cancer surgery without extra scans
NCT ID NCT07357571
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can predict how much cancer has spread to lymph nodes in patients with early-stage thyroid cancer. Researchers will review past images from 600 patients and compare them to surgical results. If the model works, it could help doctors decide the best treatment—like a less extensive surgery—without needing more invasive tests.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- contrast-enhanced ultrasound
- What this could lead to
- If successful, this could provide a non-invasive way to predict lymph node metastasis burden, helping doctors choose the right surgery for thyroid cancer patients.
- What could go wrong
- This is a retrospective study, not a controlled trial, so results may not be definitive. The model's accuracy depends on image quality and expert analysis, which may vary across centers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 600 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Dec 2025
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with T1N0M0 papillary thyroid carcinoma (PTC) who underwent initial surgical treatment and had preoperative evaluation confirmed as T1N0M0 at the medical centers participating in this study between June 2018 and June 2025.
- Ages
-
Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria 1. Patients with preoperative assessment of T1N0M0 papillary thyroid carcinoma who underwent initial surgical treatment at the medical centers participating in this study between June 2018 and June 2025. 2. Definitive diagnosis of papillary thyroid carcinoma confirmed by postoperative histopathological examination. 3. Preoperative conventional ultrasound and contrast-enhanced ultrasound (CEUS) examination of the thyroid and/or suspicious central lymph nodes were performed, with complete imaging data of acceptable quality for analysis. 4. Surgical procedures included thyroidectomy (lobectomy or total thyroidectomy) combined with central lymph node dissection (prophylactic or therapeutic) to provide a definitive pathological gold standard for lymph nodes. 5. Complete clinical pathological data and imaging data were retrievable from the Hospital Information System (HIS). Exclusion Criteria 1. Preoperative receipt of any anti-tumor treatment targeting the thyroid (e.g., radiotherapy, chemotherapy, targeted therapy, or ablation therapy). 2. Complication with other types of thyroid malignant tumors (e.g., medullary carcinoma, undifferentiated carcinoma, etc.). 3. History of neck surgery or radiotherapy that may affect the structure of cervical lymph nodes. 4. Complication with other systemic diseases that may affect CEUS perfusion characteristics or imaging evaluation (e.g., severe heart failure, liver cirrhosis, etc.). 5. Allergy to components of the ultrasound contrast agent. 6. Missing key clinical or imaging data, making complete analysis impossible.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Contrast enhanced ultrasound are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
2 sites. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
No. 33 Yingfeng Road, Haizhu District, Guangzhou City, Guangdong Province, Sun Yat-sen Memorial Hospital
RECRUITINGGuangzhou, Guangzhou, 510288, China
-
Sun Yat-sen Memorial Hospital
RECRUITINGGuangdong, Guangzhou, 510000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Ultrasound quality: experts aim to standardize liver imaging
- Ultrasound showdown: which test best spots returning liver cancer?
- Exergaming and mediterranean diet tested for thyroid cancer recovery
- Could a simple ultrasound replace liver biopsies for this rare disease?
- Can a simple ultrasound spot hidden pregnancy risks?
- Heat, not surgery: new trial aims to cure thyroid cancer without a knife