Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This study tests whether adding the targeted drug pyrotinib to standard chemotherapy can better shrink tumors before surgery in people with a common type of early breast cancer (HR-positive, HER2-low). About 160 adults with high-risk, early-stage disease will be randomly assigned…

This study tests whether adding the immunotherapy drug tirellizumab and chemotherapy before surgery can improve outcomes for people with early-stage oral squamous cell carcinoma (cT1-2N0M0). About 60 participants will be randomly assigned to receive either the drug combination fo…

This study tests whether giving two drugs (trastuzumab and a taxane) before surgery can shrink HER2-positive breast cancer that hasn't spread, allowing more women to have breast-conserving surgery instead of mastectomy. About 54 women aged 18-70 with tumors at least 2 cm will rec…

This study tests whether mecobalamin (a form of vitamin B12) can prevent hand-foot syndrome, a painful skin reaction caused by the chemotherapy drug capecitabine. 234 women with early breast cancer will receive either mecobalamin or a placebo. The goal is to see if the vitamin re…