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Vitamin B12 shows promise in preventing chemo side effect

NCT ID NCT05165069

First seen Feb 02, 2026 · Last updated Jun 16, 2026 · Updated 26 times

Summary

This phase 3 trial tests whether mecobalamin (a form of vitamin B12) can prevent severe hand-foot syndrome in early breast cancer patients taking capecitabine. About 234 women will receive either mecobalamin or a placebo. The goal is to see if the vitamin reduces painful skin reactions on hands and feet, helping patients stay on treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

    Guangzhou, Guangdong, 510120, China

Conditions

The condition(s) this trial relates to.

breast neoplasm hand-foot syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.