Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This phase 2 trial tests a combination of three drugs—liposomal irinotecan, sintilimab, and anlotinib—in 36 people with recurrent or persistent ovarian clear cell carcinoma. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have alre…

This phase 2 trial tests a combination of three drugs—inavolisib, ribociclib, and fulvestrant—in 160 Chinese women with a specific form of advanced breast cancer (PIK3CA-mutant, HR+, HER2-). The goal is to see if the combo can delay cancer growth. Participants will take daily pil…

This study tests whether blocking the artery that feeds a bile duct tumor before surgery can make it possible to remove the cancer safely. It includes 33 adults with advanced bile duct cancer that currently cannot be operated on. The main goal is to see how many patients are aliv…

This study tests a drug called sacituzumab in 22 people with a rare and aggressive type of ovarian cancer (clear cell carcinoma) whose tumors grew despite immunotherapy. The drug is an antibody-drug conjugate that targets a protein on cancer cells to deliver chemotherapy directly…

This study tests a combination of the immunotherapy drug sintilimab and a chemotherapy regimen called FOLFIRI as a second-line treatment for people with advanced HER2-negative stomach cancer that has progressed after initial therapy. The goal is to see if this approach can delay …

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This early-stage trial tests whether tocilizumab, an anti-inflammatory drug, can help women with a rare breast condition called granulomatous lobular mastitis that hasn't improved with steroids. About 31 women aged 20-50 will receive two doses of the drug intravenously. The main …

This study tests a triple-combination inhaler (budesonide/glycopyrronium/formoterol) in 23 smokers aged 40-75 who have PRISm, a lung condition that often leads to COPD. Participants will use the inhaler for 12 weeks to see if it improves lung function, symptoms, and quality of li…

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This study tests whether a new drug, trastuzumab rezetecan, works as well as or better than the current drug trastuzumab deruxtecan for women with advanced HER2-positive breast cancer that has worsened after previous treatment. About 100 women will be randomly assigned to one of …

This study tests a new mRNA vaccine designed to help the immune system attack cancer cells. The vaccine targets a protein found only in tumors and is given together with an immunotherapy drug (anti-PD-1). About 60 adults with advanced solid tumors that cannot be removed by surger…

This study tests whether giving the steroid methylprednisolone along with a standard clot-removal procedure helps people recover better after a severe stroke caused by a large blockage. About 912 adults aged 18-85 with acute ischemic stroke will be randomly assigned to receive ei…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This study looks at whether removing keloids surgically and then applying a radioactive patch (32P) can prevent them from returning. About 401 people with keloids will get this treatment and be checked every 6 months for 2 years. The goal is to see how well the combo works and wh…

This study tests whether a new two-drug combination (sacituzumab govitecan plus toripalimab) works better than a standard combination (toripalimab plus nab-paclitaxel) for people with advanced triple-negative breast cancer that has not been treated before. About 150 adults with P…

This study compares a single chemotherapy drug (paclitaxel) to the standard two-drug combo (paclitaxel plus carboplatin) as initial treatment before surgery for advanced ovarian cancer. It is for patients whose tumors have high levels of a protein called PARK2, which may make the…

This study tests three different doses of the drug famitinib combined with camrelizumab in 120 people with recurrent or metastatic cervical cancer that cannot be cured by standard treatments. The goal is to find a dose that keeps the cancer under control while causing fewer sever…

This study tests an artificial intelligence (AI) model that uses images from prostate biopsies to predict when the cancer will stop responding to hormone therapy. The AI was developed using past data and performed well in initial tests. Now, researchers will prospectively test it…

This study looks at whether a special ultrasound can accurately detect if breast cancer has completely disappeared from lymph nodes after chemotherapy. About 150 women with cancer that spread to their lymph nodes will have a small clip placed in a cancerous node before treatment.…

This study tests a surgical technique to prevent arm lymphedema (chronic swelling) in breast cancer patients at high risk. During standard lymph node removal, doctors will rotate a small flap of tissue from the chest wall into the armpit to support lymphatic drainage. 100 partici…

This study compares two ways of giving a large-volume subcutaneous injection of pertuzumab and trastuzumab (Phesgo) to breast cancer patients: one using a machine that injects at a constant speed, and the other using a nurse's hand. Forty female patients will receive both methods…

This study tests if a new treatment—mild nerve stimulation on the ear plus personalized music—can reduce the annoyance of chronic tinnitus (ringing in the ears) better than standard therapy. About 386 adults with bothersome tinnitus for at least 6 months will be randomly assigned…

This study will test an artificial intelligence system designed to predict when a cancer might spread to other parts of the body. Researchers will enroll 10,000 adults with malignant tumors but no current signs of metastasis. The AI analyzes routine imaging and medical records to…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…

This study looks at how well immunotherapy shrinks tumors and lymph node metastases in 5,000 people with various cancers. Researchers will track changes in tumor and lymph node size after treatment and explore factors like beta-blocker use that might affect results. The goal is t…

This study looks at whether a color Doppler ultrasound feature called the 'twinkling artifact' can make breast tissue marker clips easier to see. These clips are placed to mark suspicious areas in the breast or lymph nodes. The study will review past images from about 86 women wi…

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…