Shanghai Zhongshan Hospital

This study is testing whether adding an injectable medication called treprostinil to a patient's current oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). All 32 participants will receive the injection alongside their …

This study is testing a two-step treatment for pancreatic cancer that is difficult or impossible to remove with surgery right away. The goal is to see if giving two different combinations of chemotherapy drugs plus an immunotherapy drug can shrink the tumors enough so that surger…

This study is testing whether a 3-day intravenous drug, sivelestat sodium, can help protect the function of vital organs like the lungs, kidneys, and liver in patients recovering from emergency surgery for a torn aorta. Researchers will compare the drug to a placebo in 236 patien…

This study is testing whether a combination of two drugs can help prevent a rare and aggressive type of liver cancer from returning after surgery. About 75 patients who have had their tumor removed but are at high risk of it coming back will receive both an immunotherapy drug (gi…

This study is for adults with advanced liver cancer that cannot be removed by surgery. It compares two different drug combinations, both given alongside a standard procedure called TACE that delivers chemotherapy directly to the liver. The goal is to see which combination is bett…

This early-stage study is testing a new type of CAR-T cell therapy, called XW-LTH-03, for people with advanced stomach cancer that has spread and no longer responds to standard treatments. The main goal is to see if the treatment is safe and what side effects it causes. Researche…

This study aims to find the best treatment approach for people with advanced liver cancer that cannot be removed by surgery initially. First, patients receive a combination of targeted drugs and localized chemotherapy to shrink tumors. Then, for those whose tumors shrink enough, …

This study is testing whether a new national hospital accreditation program can improve the quality of care for people hospitalized with heart failure. Over 6,000 patients from hospitals across China will participate, with some hospitals using the new standardized program and oth…

This study is testing whether a surgically implanted brain-computer interface can help people with paralysis regain hand and limb function. Ten participants with tetraplegia (paralysis of all four limbs) will have electrodes placed in their brain to decode movement intentions, wh…

This study is testing whether an artificial intelligence (AI) system can help doctors choose the best medications for people with a specific type of heart failure. About 1,200 patients from 60 hospitals will participate. The main goal is to see if AI-guided care leads to fewer ho…

This study compares a newer combination diabetes injection (iGlarLixi) against standard insulin treatments in adults whose type 2 diabetes isn't well controlled with pills alone. About 1,300 participants across China will receive either the combination injection or standard insul…

This study is testing a small implant called the AnchorMan® device, which is placed in the heart to seal off an area where blood clots often form in people with atrial fibrillation. The main goal is to see how quickly and completely the body's own tissue grows over the device, wh…

This study aims to find the best way to treat dangerous bleeding in the esophagus and stomach caused by portal hypertension, a complication of liver disease. Researchers will compare two types of procedures—endoscopic therapy and interventional radiology—to see which one better p…

This study is for people with a type of advanced liver cancer called intrahepatic cholangiocarcinoma. It tests whether a new evaluation system (TDTP-RECIST) can better guide doctors on when to perform surgery after patients have received initial drug therapy (GOLP regimen). The g…

This study is testing a new approach for treating stomach cancer. After surgery, a blood test will check for tiny traces of leftover cancer. The goal is to see if patients with a clean blood test can safely skip the usual harsh chemotherapy, avoiding its severe side effects, with…

This study tests whether a 7-day personalized antibiotic treatment works as well as a 14-day treatment for people with stubborn H. pylori stomach infections that didn't clear with previous treatments. Researchers will use stool tests to identify which antibiotics the bacteria are…

This study is testing a new medical device called the FARAPULSE™ system, which uses pulsed field energy to treat a common type of irregular heartbeat called paroxysmal atrial fibrillation. The procedure aims to electrically isolate specific heart veins to prevent faulty electrica…

This study is testing whether adding acupuncture to standard care helps prevent the return of a dangerous irregular heartbeat (atrial fibrillation) after a common heart procedure called catheter ablation. It will involve 120 people who have persistent atrial fibrillation and have…

This study is testing if surgically disrupting a nerve in the tongue can make chemotherapy and immunotherapy work better for people with advanced tongue cancer. About 69 adults will have the nerve procedure, then receive two cycles of drug treatment before their main cancer-remov…

This study aims to understand why some patients with a specific type of stomach cancer respond well to immunotherapy while others do not. It will enroll 15 Asian patients with this cancer type who are scheduled for surgery after receiving immunotherapy. The goal is to learn what …

This study aims to find the safest and most effective way to treat dangerous swollen veins in the stomach and esophagus, which are caused by high blood pressure in the liver. Researchers will follow over 1,300 patients who receive either a scope-based treatment or other medical/s…

This study is for people whose thymic cancer has spread to the lining of their lungs. It compares two approaches: surgery alone versus surgery followed by a special heated chemotherapy wash applied directly inside the chest. The goal is to see if this heated chemo wash can better…

This study aims to see if one of two different drug combinations can help shrink tumors before surgery for people with a specific type of advanced stomach or gastroesophageal cancer. About 30 participants will be randomly assigned to receive either an immunotherapy drug plus chem…

This study is testing if adding the drug pirfenidone to standard treatment can better control Takayasu arteritis, a rare disease that causes scarring and narrowing of blood vessels. Researchers will compare pirfenidone to a placebo in 92 patients already on standard therapy to se…

This study aims to see if a shorter, 7-day personalized antibiotic treatment works as well as the standard 14-day course for clearing a common stomach bacteria called H. pylori. Researchers will use a stool test to check which antibiotics the bacteria are resistant to, then assig…

This study is for people with advanced lung cancer who had chemotherapy and immunotherapy before surgery, but cancer cells were still found in their lymph nodes after the operation. It tests whether adding a targeted radiation treatment to the standard immunotherapy drug helps ke…

This study aims to find the better treatment to help control muscle weakness in people with a specific type of myasthenia gravis who need surgery to remove a chest tumor called a thymoma. It will compare a newer drug, efgartigimod, against the standard treatment, intravenous immu…

This study aims to compare four different imaging tracers to see which one best shows prostate cancer tumors on PET/CT scans. Researchers will enroll 9 men with advanced prostate cancer who have already shown positive results on a standard PSMA scan. The study focuses on measurin…

This study is testing whether an injectable medication called octreotide microspheres can prevent a serious complication called pancreatic fistula after surgery to remove part of the pancreas. About 230 patients scheduled for this specific pancreas surgery will be randomly assign…

This study is testing whether a special breathing device called the MetaNeb System can prevent and treat lung collapse in patients recovering from esophageal cancer surgery. Researchers will compare the device to standard care in 178 adults admitted to the ICU after surgery. They…

This study is testing a special eye-tracking device to see if it helps patients in the intensive care unit (ICU) who cannot speak communicate their needs. Researchers will compare the device to standard communication methods to see if it makes communication easier, reduces patien…

This study is testing whether a new eye-tracking computer system can help patients in intensive care who cannot speak communicate their needs more easily. Researchers will compare this high-tech system to traditional low-tech methods like writing boards and hand signals. The goal…

This study is testing if using a special pacemaker set to a faster-than-normal heart rate can help people with right heart failure and a severely leaky tricuspid valve. It will enroll 24 patients who have a slow resting heart rate and need a pacemaker. Researchers will implant th…

This study aims to understand how blood flow in the lungs changes when people hold their breath at different lung volumes. Healthy participants will undergo a non-invasive imaging procedure while holding their breath after inhaling and after exhaling. The goal is to gather basic …

This study aims to understand how often a second heart condition called cardiac amyloidosis occurs in people with aortic stenosis (a narrowed heart valve). Researchers will observe 143 patients aged 65-85 who are scheduled for a valve replacement procedure. They will track patien…

This study aims to develop a computer program that can predict which patients with severe lung failure (ARDS) are most likely to die in intensive care after receiving a special positioning treatment. Researchers will analyze past medical records from 377 patients to teach the pro…

This nationwide study in China aims to learn more about a specific, hard type of plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is difficult to treat. Researchers will use advanced imaging tools during standard heart procedures to see…

This study aims to see if artificial intelligence (AI) can watch video of patients in the Intensive Care Unit (ICU) and spot early warning signs of dangerous events like agitation or accidentally pulling out medical tubes. About 300 patients will have a small, privacy-protected c…

This study aims to understand if tracking a natural gas in a patient's breath (exhaled carbon monoxide) over time can help doctors predict how well a critically ill patient will recover. Researchers will measure this gas daily for up to a week in 220 adult ICU patients and see if…