Shanghai Zhongshan Hospital

This study tests whether combining two drugs (becotatug vedotin and pucotenlimab) before surgery can shrink advanced mouth or throat cancer. About 26 adults with stage III or IVa cancer that has not spread will receive the treatment. The goal is to see how many patients have most…

This study tests whether a 7-day course of antibiotics tailored to a person's stool test works as well as a 14-day course for treating H. pylori infection. About 544 adults who have not been treated before will provide a stool sample to guide their medication. The goal is to see …

This study looks at two treatments—endoscopy and a procedure called TIPS—to prevent repeat bleeding in people with high blood pressure in the liver (portal hypertension) that causes swollen veins in the stomach or esophagus. Over 1,000 adults who have had a bleeding episode will …

This study tests whether a blood thinner called rivaroxaban can safely prevent further bleeding in people with liver cirrhosis who have both high-risk varices (enlarged veins) and a blood clot in the portal vein. About 175 participants will receive the drug starting 48 hours afte…

This study tests two different drug combinations given before surgery for people with a specific genetic type of stomach or gastroesophageal junction cancer (dMMR/MSI-H). The goal is to see if these treatments can completely eliminate the tumor before it is removed. About 30 adul…

This study tests a new treatment for people with colorectal cancer that has spread and not responded to at least two prior therapies. Participants receive targeted radiation to tumors in the lung or liver, followed by a combination of three drugs: an immunotherapy (sintilimab), a…

This early-stage study tests a single inhaled dose of a lab-made protein (rhKGF-2) in 24 adults with moderate-to-severe ARDS who are on a breathing machine. The main goal is to see if the drug is safe and tolerable, while also checking for signs it might improve oxygen levels. Pa…

This study tests a device called AnchorMan that closes a small pouch in the heart to lower stroke risk in people with atrial fibrillation who cannot take blood thinners. About 306 participants will get the device and be followed for 6 months to see how well the heart tissue grows…

This study tests whether a national hospital accreditation program for heart failure care can improve patient outcomes. About 6,240 adults hospitalized with heart failure will be enrolled across multiple hospitals in China. Hospitals are randomly assigned to either the accreditat…

This study tests whether combining an immunotherapy drug (cadonilimab) with a chemotherapy pill (capecitabine) can prevent a rare mixed liver cancer from returning after surgery. About 75 adults who had their tumor completely removed but are at medium-to-high risk of recurrence w…

This trial tests if surgically disrupting a nerve in the tongue can make chemoimmunotherapy work better for people with advanced tongue cancer. About 69 adults with stage cT3 or cT4 tongue cancer will receive the nerve procedure, two cycles of drug therapy, and then surgery. The …

This study tests whether an artificial intelligence (AI) system can help doctors choose the best medications for people with heart failure with reduced ejection fraction (HFrEF). About 1,200 participants from 60 hospitals will be enrolled, with hospitals randomly assigned to use …

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can improve outcomes for people with a rare type of skin cancer called acral melanoma. About 30 adults with stage IIB or III melanoma that can be removed will receive the drugs…

This study tests whether a 7-day personalized treatment for H. pylori works as well as a 14-day one. About 290 adults who have failed prior treatment will provide a stool sample to guide drug choice. The goal is to see if the shorter course is just as effective, safer, and more c…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats after a common heart procedure called catheter ablation. About 120 adults with persistent atrial fibrillation will be randomly assigned to receive either acupuncture plus us…

This study tests whether adding a three-drug pill regimen to a standard liver cancer procedure (TACE) helps people with liver cancer that cannot be surgically removed live longer compared to the usual approach of TACE plus targeted therapy and immunotherapy. About 222 adults who …

This study looks at people with advanced liver cancer that cannot be removed by surgery at first. They will receive a combination of treatments (chemo directly into the liver, anti-angiogenic drugs, and immunotherapy) to shrink the tumor. If the tumor shrinks enough or becomes re…

This study tests whether adding pirfenidone, a drug used for lung scarring, to standard treatment can improve blood vessel damage in people with Takayasu arteritis. About 92 adults aged 18-60 will receive either pirfenidone or a placebo for 6 months. The goal is to see if the dru…

This study tests whether a specific sequence of two different chemotherapy combinations, each paired with an immunotherapy drug (PD-L1 antibody), can shrink borderline resectable or locally advanced pancreatic cancer enough to allow surgical removal. About 77 adults with this typ…

This study compares surgery alone to surgery plus heated chemotherapy (HITOC) for people with thymic tumors that have spread to the lining of the chest. The goal is to see if adding HITOC helps prevent the cancer from coming back and improves survival. About 202 adults aged 18-75…

This study is for people with stage III non-small cell lung cancer who had chemotherapy and immunotherapy before surgery, then surgery to remove the tumor, but still had cancer in their lymph nodes. Researchers want to see if adding targeted radiation to the lymph nodes after sur…

This study tests whether a special pacemaker that speeds up the heart can help people with right-sided heart failure and severe tricuspid regurgitation. Twenty-four adults with a low resting heart rate will get the pacemaker and be followed for 6 months. The goal is to see if a f…

This study tests a new treatment called XW-LTH-03, which uses specially engineered immune cells (CAR-T cells) to target two proteins, CD73 and AXL, found on advanced stomach cancer cells. The trial includes 42 adults with stage IV stomach cancer that has not responded to standard…

This study tests whether giving two drugs (SHR-1701 and famitinib) before surgery can improve outcomes for people with a rare and aggressive skin cancer called mucosal melanoma. After surgery, treatment is tailored based on how well the tumor responded. The trial involves 70 adul…

This study tests a new injectable medicine called iGlarLixi (a mix of insulin and a GLP-1 drug) against standard diabetes treatments in 1,316 adults in China whose type 2 diabetes is not well controlled with oral pills. The goal is to see if iGlarLixi lowers blood sugar better an…

This study tests a new method for placing a pacing lead in the heart to treat heart failure. The goal is to target a specific area called Bachmann's bundle to improve heart function. About 40 adults with heart failure will be enrolled. The study will check if the new method is sa…

This study tests whether adding an injectable medication called treprostinil to standard oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). About 32 adults will receive the drug and be monitored for 3 months, with follo…

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove for grasping objects. The trial includes surgery, rehabili…

This study tests a new way to treat atrial fibrillation (AF), a condition where the heart beats irregularly. The method uses short electrical pulses instead of heat to block faulty signals in the heart. Thirty adults with AF will receive this treatment during a standard procedure…

This study tests a new procedure called pulsed field ablation (PFA) using the FARAPULSE™ system to treat people with a type of irregular heartbeat called paroxysmal atrial fibrillation. The goal is to use targeted electric pulses to isolate the veins that trigger the abnormal rhy…

This study tests whether a newer drug, efgartigimod, works better and is safer than standard intravenous immunoglobulin (IVIG) for people with myasthenia gravis caused by a thymoma tumor. About 64 adults who need surgery to remove the tumor will receive one of the two treatments …

This study tests a new treatment plan for people with intermediate or advanced liver cancer. It combines chemotherapy delivered directly to the liver, a procedure to block the tumor's blood supply, and two drugs (apatinib and camrelizumab) that help the immune system fight cancer…

This study tests whether a drug called sivelestat sodium can protect organ function in people who have surgery for a life-threatening tear in the main artery from the heart (type A aortic dissection). About 236 adults will receive either the drug or a placebo through a vein for 3…

This study will enroll 10,000 adults with chest pain at five hospitals to see if an artificial intelligence model can analyze a standard ECG and quickly identify acute type A aortic dissection, a life-threatening tear in the heart's main artery. The AI's predictions will be compa…

This study tests three new radioactive imaging agents against the standard one to see which best highlights prostate cancer tumors on PET/CT scans. Nine men with advanced prostate cancer will receive both the standard and new agents so doctors can compare how clearly tumors appea…

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in 330 high-risk patients. AKI is a common and serious complication with no current prevention. Participants receive either the gas or a placebo during surgery and are …

This study tests if a drug called octreotide can prevent a common complication called pancreatic fistula after surgery to remove part of the pancreas. About 230 adults will receive either the drug or a placebo before surgery, and doctors will check for leaks over 60 days. The goa…

This study tests if the MetaNeb system, a breathing device, can prevent or treat lung collapse (atelectasis) in 178 adults after esophageal cancer surgery. Participants will be randomly assigned to receive either standard care or MetaNeb therapy. The main goal is to see if MetaNe…

This study looks at whether pressing a specific spot on the neck (called the Tian Tu acupoint) can help people cough better after esophageal surgery. Thirty adults who had this surgery will take part. Researchers will measure cough strength and belly pressure with and without the…

This study tests if an eye-tracking system can help ICU patients who cannot speak (due to breathing tubes or injuries) communicate their needs. Sixty adults will use either the eye-tracking system or traditional tools like writing boards. The goal is to see if the eye-tracking sy…

This study tests a special eye-tracking tool that lets non-verbal ICU patients communicate by looking at a screen. Researchers want to see if it reduces frustration, anxiety, and time spent in the ICU compared to usual methods. About 54 adults who cannot speak due to breathing tu…

This early-stage study tests the safety of a new treatment for interstitial lung disease (ILD), a group of conditions that cause lung scarring and breathing problems. The treatment uses tiny particles called extracellular vesicles, derived from stem cells, which are inhaled as a …

This study aims to see if a structured arm exercise program helps people recover better after getting a heart device (CIED) implanted. The program focuses on reducing stiffness, pain, and disability in the arm on the side of the implant. Researchers will follow 600 adults for up …

This study looks at how common cardiac amyloidosis (a protein buildup in the heart) is in people with aortic stenosis (a narrowed heart valve). Researchers will follow 143 patients getting a valve replacement to compare those with and without the protein buildup. The goal is to l…

This study looks at a specific type of stomach cancer (dMMR/MSI-H) that often responds well to immunotherapy, but about half of patients do not. Researchers want to understand why some patients benefit and others don't, by studying tumor samples before and during treatment. The g…

This study is watching 500 adults in China who have hard, bony-like plaques (calcified nodules) in their heart arteries. Doctors will use special cameras inside the blood vessels to see these plaques in detail and track how patients do over time. The goal is to learn more about t…

This study looks at 540 high-risk heart surgery patients to find metabolic markers that can predict acute kidney injury (AKI). Researchers will use advanced techniques to track changes in the body's chemistry before and after surgery. The goal is to create a warning system that h…

This study aims to see if a blood test that detects tiny bits of tumor DNA (ctDNA) can help doctors decide which stomach cancer patients need extra chemotherapy after surgery and which can safely skip it. About 304 people with locally advanced stomach cancer will be randomly assi…

This study looks at 377 adults with severe lung failure (ARDS) who received a treatment called prone positioning (lying on the belly to help breathing). Researchers will use computer models to find patterns in patient data that can predict who is at highest risk of dying in the I…

This study measures exhaled carbon monoxide daily in 220 adult ICU patients for up to 7 days. The goal is to see if different patterns of this gas relate to serious outcomes like death, kidney injury, and how long patients stay in the ICU. Participation involves only breath tests…

This study follows 320 adults with pancreatic cancer to see if ongoing stress, anxiety, or poor sleep is linked to shorter survival or worse treatment response. Participants fill out simple questionnaires about their mood and sleep and give a small blood sample at regular visits.…

This study tests whether artificial intelligence can analyze video recordings of ICU patients to predict dangerous events, such as pulling out breathing tubes or becoming agitated. About 300 patients will have a small camera above their bed that records movements and sleep patter…

This study looks at whether a simple blood test that detects tiny traces of cancer DNA (called ctDNA) can help doctors decide which patients with advanced stomach cancer can safely skip chemotherapy after surgery. About 90 adults with stage III or IV stomach cancer will be enroll…

This study will use ultrasound to measure how well the diaphragm moves in 35 critically ill patients. The goal is to compare different ultrasound methods to see which one gives the most consistent results, especially for the left side of the diaphragm. The findings may help docto…

This study looks at 270 people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be removed right away. After initial chemotherapy, doctors will use a special evaluation system (TDTP-RECIST) to decide whether to continue medication or perform surgery. The …

This study looks at how blood flow in the lungs changes depending on whether you hold your breath after breathing in or out. One hundred healthy adults will receive a small, fast injection of salt water while wearing a special belt that measures electrical signals. The goal is to…