Shanghai Zhongshan Hospital

This study tests a combination of two types of drugs (anti-PD-1/PD-L1 and anti-VEGF) in 50 adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if the treatment is safe and helps shrink tumors or slow their growth. Participants will receive the …

This study compares two surgical approaches for people with locally advanced stomach cancer: laparoscopic (keyhole) total gastrectomy versus open total gastrectomy. About 1,018 participants will be randomly assigned to one of the two procedures. The main goal is to see which meth…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium deposits in their heart arteries. About 656 adults will first have the calcium broken up with special tools, then receive either the balloon or the stent. Researche…

This study tests a new combination of drugs as the first treatment for people with advanced intrahepatic cholangiocarcinoma, a type of liver cancer that cannot be removed by surgery. About 35 participants will receive an oral drug called chidamide along with standard chemotherapy…

This study tests whether giving a combination of envafolimab (an immunotherapy) and two chemotherapy drugs before surgery can help shrink tumors in people with locally advanced esophageal cancer. About 26 adults with operable disease will receive the treatment and then have surge…

This study looks at whether a balanced gelatin solution is better than standard fluids for people with sepsis (a severe infection) who need emergency abdominal surgery. Sepsis causes fluid loss, which can lead to low blood pressure and organ damage. The trial will compare the two…

This study tests whether a new chemotherapy combination (NALIRIFOX) plus targeted therapy works better than the standard treatment (FOLFOX) plus targeted therapy for people with metastatic colorectal cancer that cannot be removed by surgery. About 144 adults who have not had prio…

This study tests whether a drug called indobufen works better and causes fewer side effects than aspirin in people over 65 who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen plus ticagrelor or aspirin plus tica…

This early-phase study tests a one-time infusion of specially engineered immune cells (CAR-T cells) that target and calm the immune attack on the pancreas in people with early type 1 diabetes. The goal is to preserve the body's own insulin-making cells and reduce the need for inj…

This study tests whether montelukast, a common asthma medication, can reduce heart muscle damage and prevent heart failure in people having a severe type of heart attack called anterior STEMI. About 512 adults will receive montelukast or a placebo right after emergency artery-ope…

This early-phase study is testing whether giving a combination of chemotherapy and immunotherapy before any surgery can shrink esophageal cancer enough to allow doctors to remove the tumor through a scope, preserving the esophagus. About 60 adults with a specific type of esophage…

This study tests whether a continuous 24-hour intravenous infusion of lidocaine can lower the chance of serious lung complications (like pneumonia or needing a breathing machine) in adults who need emergency abdominal surgery for an infection inside the belly. About 428 participa…

This study looks at how well the drug surufatinib works for people with advanced neuroendocrine tumors (a type of cancer) in real-life medical settings. About 350 adults will take the drug by mouth, either alone or with other treatments, and be monitored for tumor shrinkage, side…

This study looks at the best way to maintain weight loss after initial success with a weight-loss drug called mazdutide. It will test whether a year of intensive lifestyle changes, a lower dose of the drug, or both together can help people with obesity keep the weight off. The st…

This study tests whether giving a PCSK9 inhibitor (a powerful cholesterol-lowering drug) very early in the hospital, along with standard care, can reduce the risk of major heart problems like death, another heart attack, or stroke over the next year. About 1,500 adults who recent…

This study tests whether asiaticoside, a compound from the herb Centella asiatica (Gotu Kola), can help adults with overweight or obesity lose weight. Researchers will measure changes in metabolic rate and body weight over 12 weeks. The study involves 30 participants and aims to …

This study tests a new treatment called HN2301 for people with Graves' disease that hasn't improved with standard therapy. HN2301 uses a special injection to turn the body's own immune cells into cells that attack the overactive thyroid. The goal is to safely bring thyroid levels…

This study is for people with stomach cancer that has spread to a few other places in the body. It tests whether adding surgery to remove the main tumor and some of the spread, along with other local treatments, to a mix of immunotherapy and chemotherapy helps people live longer …

This early-stage study tests a new treatment called RD06-05, made from donor immune cells engineered to target and calm the faulty immune response in Graves' disease. It aims to see if a single infusion can safely restore normal thyroid function without needing lifelong medicatio…

This study is for people with advanced bile duct cancer that cannot be removed by surgery. It tests a combination of two chemotherapy drugs (gemcitabine and cisplatin) plus immunotherapy (anti-PD-1/PD-L1 antibodies) as a first treatment. The goal is to see if this combination is …

This study tests a powerful mix of treatments for people with advanced liver cancer that cannot be surgically removed. The approach combines tumor destruction (ablation), targeted therapy (lenvatinib), immunotherapy (tislelizumab), and a procedure that blocks the tumor's blood su…

This study tests a new imaging method called µQFR to see how well it can detect blocked blood flow in side branches of heart arteries after a single stent is placed. About 290 adults with complex coronary artery disease will be enrolled. The goal is to see if this non-invasive ap…

This study looks at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) works better than a standard face mask to prevent low oxygen levels during a sedated stomach scope. It involves 200 adults with visceral obesity (belly fat) who are …

This study tests whether fecal microbiota transplantation (FMT) can reduce symptoms of irritable bowel syndrome (IBS). About 102 adults with IBS who haven't gotten better with standard treatments will receive FMT via capsules or a tube once a month for three months. Researchers w…

This study follows 1384 people with high blood pressure in the liver that causes enlarged veins in the esophagus and stomach. Researchers compare those who get endoscopic treatment (using a scope) with those who get other treatments like medicine or surgery. The goal is to see wh…

This study looks at why some people with coronary heart disease continue to have plaque buildup in their arteries even when they are on intensive cholesterol-lowering therapy. Researchers will follow 900 adults aged 18 to 75 who have had a stent placed and have mild blockages nea…

This study will test a new, faster CT scanner to see if it can better detect risky plaque in heart arteries and measure blood flow. About 500 adults with known or suspected heart disease will get a special CT scan, and results will be compared with standard tests like angiograms …

This study is creating a large collection of medical data and samples from 1,000 people with portal hypertension, a condition that can cause life-threatening bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better underst…

This study follows 189 adults who experienced delirium in the ICU to understand how it impacts their physical, thinking, and emotional health after moving to a regular hospital ward. Researchers will use questionnaires to track recovery until the patient goes home. The goal is to…

This observational study looks at whether combining information from CT scans, blood tests, and pathology reports can more accurately predict how pancreatic cancer will progress. Researchers will collect data from medical records of about 1,030 people who had surgery for pancreat…

This study looks at how an 8-week exercise program changes the body and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers, and use advanced cell analysis to find clues about how exercise impro…

This study is testing whether a non-invasive blood pressure monitor can detect blockages in the heart's main pumping chamber in people with hypertrophic cardiomyopathy (HCM). Researchers will compare blood pressure readings with standard heart ultrasound measurements in 800 adult…

This study looks at people with cirrhosis (scarred liver) who also have a blood clot in the main liver vein and enlarged veins in the stomach. Researchers want to find out what helps these clots dissolve over time. The goal is to help doctors and patients better understand the di…

This study will follow 6,000 people who had a heart attack and received a stent (a small tube to open blocked arteries) at Zhongshan Hospital. Researchers will collect information on their health during the hospital stay and for up to two years after. The goal is to better unders…

This study looks at heart plaque in people with diabetes using a special camera that combines two imaging methods. Researchers want to see if a new measurement can help predict serious heart problems like heart attacks or chest pain. About 1,500 participants will be followed for …