Shanghai Zhongshan Hospital

This study looks at whether taking vitamin B1 for one year can reduce the size and number of colon polyps in people with familial adenomatous polyposis (FAP), a genetic condition that leads to many polyps and a high risk of colon cancer. Ten adults with FAP will take oral vitamin…

This early-phase study tests a new approach for people with type 2 diabetes who need insulin. Doctors will take a small sample of pancreatic tissue, grow insulin-making cells in the lab, and transplant them under the belly skin. The goal is to see if these cells can safely produc…

This early-phase study tests a new treatment for people with advanced liver cancer that has not responded to standard therapies. The treatment uses the patient's own immune cells, modified to target a protein called IL1RAP on cancer cells. The main goals are to check safety and f…

This study tests whether adding a new antibody (HLX22) to standard treatment (trastuzumab plus chemo) can shrink tumors better in people with advanced HER2-positive pancreatic cancer. About 45 adults who have not had prior treatment for metastatic disease will receive the combina…

This study tests whether giving a combination of immunotherapy (Toripalimab), a targeted drug (Lenvatinib), and chemotherapy (GEMOX) before surgery can improve outcomes for people with a high-risk type of bile duct cancer. About 178 participants will be randomly assigned to recei…

This study tests two drugs, candonilimab and LM-302, in people with advanced biliary tract cancer that has not responded to standard chemotherapy and immunotherapy. The goal is to see if the combination can shrink tumors or slow the disease. About 78 adults with a specific protei…

This study is gathering medical data, images, and blood samples from 2,000 people who have had a heart attack. Researchers want to learn more about the disease and find new ways to predict and prevent future heart problems. The goal is to improve personalized diagnosis and treatm…