Insel Gruppe Ag, University Hospital Bern

This study is testing how well a higher dose (8mg) of the drug Aflibercept, also known as Eylea, works in the first two months for people with wet age-related macular degeneration (AMD). Researchers will measure changes in retinal fluid and vision in 50 participants. The goal is …

This study looks at people with atrial fibrillation (an irregular heartbeat) who had a stroke even while taking blood thinners. It tests whether closing a small heart pouch (left atrial appendage) with a device, while continuing blood thinners, can better prevent another stroke, …

This study tests whether the drug landiolol can safely keep heart rate below 90 beats per minute during major surgery in 114 patients at risk for heart problems. The goal is to see if this approach is feasible and might reduce heart injury after surgery. Participants receive land…

This phase 2 trial is testing whether adding a procedure called radiofrequency ablation (bRFA) to standard chemotherapy and immunotherapy is safe for people with bile duct cancer that cannot be removed by surgery. About 36 participants will be randomly assigned to receive either …

This study tests whether adding high-dose steroids to standard aspirin treatment helps children who had a stroke due to inflamed brain arteries. About 70 children from over 20 hospitals will be randomly assigned to get either steroids plus aspirin or aspirin alone. The goal is to…

This study tests whether a personalized algorithm can determine the best length of time for patients to take two blood thinners after getting a heart stent. About 2,788 adults who have had a stent placed will be assigned to either standard care or algorithm-guided treatment. The …

This study tests a new approach for people with atrial fibrillation who have had a heart stent. Instead of taking multiple blood thinners together for months, the new plan uses just one drug at a time: an antiplatelet for the first month, then a switch to an anticoagulant alone. …

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas who are at high risk of complications. The main goal is to see if total removal helps patients live longer without hurting …

This study looks at 320 adults who had a brain bleed (subarachnoid hemorrhage) to see if the type of IV fluid they receive affects their recovery. The goal is to find out if a fluid with a specific salt content can reduce dangerous complications like blood vessel spasms and brain…

This study tests whether placing a balloon in the main artery (aorta) during CPR, along with standard life support, helps restart the heart more often than standard CPR alone. About 98 adults having a cardiac arrest in the hospital will take part. The main goal is to see if the h…

This study tests a new type of PET/CT scan (AzaFol) to see if it can better diagnose giant cell arteritis, a condition that causes inflamed blood vessels. About 70 people with suspected GCA will get the new scan and a standard scan to compare accuracy. The goal is to improve diag…

This study compares a new contrast agent, gadopiclenol, to the standard one used in MRI scans for people with suspicious findings in their kidneys or adrenal glands. About 104 adults will be randomly assigned to receive one of the two agents during a single MRI appointment. The g…

This study tests whether adding a specific laparoscopic stitch (McCall suture) during a routine hysterectomy can prevent the top of the vagina from dropping later on (pelvic organ prolapse). About 114 women having a laparoscopic hysterectomy for non-prolapse reasons will be rando…

This study tests whether an eHealth app that coaches parents can help lower the energy balance in children aged 2-6 who are already above the 97th BMI percentile. About 148 families will be randomly assigned to use the app or receive standard care. The goal is to see if the app c…

This study tests whether an eHealth app can help parents of children under 6 reduce their kids' exposure to second-hand smoke. About 160 families will use the app or receive standard care. The goal is to lower children's urine cotinine levels and prevent asthma and other diseases…

This study compares two long-acting drugs, indapamide and chlorthalidone, to the standard short-acting drug hydrochlorothiazide for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the past 10 years will participate. The goal is to see …

This study tests whether a midazolam nasal spray can quickly reduce acute anxiety in adults receiving palliative care. Participants will be randomly assigned to receive one of two doses of the spray or a placebo. The researchers will measure anxiety levels before and 30 minutes a…

This study tests whether a new type of deep brain stimulation called Burst-DBS can reduce chronic pain in people with facial nerve damage or pain after a stroke. Twenty adults will have electrodes placed in the thalamus and compare Burst-DBS to standard continuous stimulation ove…

This study tests a mobile app called Mio-App designed to help children and teenagers with cancer improve their thinking, memory, and motor skills. The app includes cognitive and physical exercises along with questions to boost self-awareness. Researchers will enroll 40 participan…

This small pilot study tests whether a special rocking bed (Somnomat Casa) can improve sleep quality in people with Parkinson's disease. Fifteen participants will use the bed at home for two months, and researchers will measure how acceptable and helpful the treatment is. The goa…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study tests a patient-centred program to help adults aged 65 and older reduce their use of sleeping pills like benzodiazepines. The program includes a tapering plan, educational materials, and cognitive behavioural therapy techniques. Researchers will track whether participa…

This study tests whether hormone replacement therapy (HRT) or cognitive behavioral therapy (CBT-I) can help perimenopausal women sleep better. Fifty-four women with insomnia and hot flashes will receive either HRT, weekly CBT-I sessions, or sleep hygiene tips for 8 weeks. Researc…

This study tests a special training program called Mio-Training for children and teens with ADHD. The program combines thinking exercises with physical coordination tasks to improve self-awareness and problem-solving skills. Researchers will enroll 40 participants aged 8-16 to se…

This study tests whether using a tiny ultrasound camera inside the heart during ablation can reduce or replace X-rays. Ablation uses catheters to fix abnormal heart rhythms, and X-rays are normally used to guide them. Half of the 70 participants will get the ultrasound-guided pro…

This study tests whether removing the chest tube on the same day as minor lung surgery is safe. About 304 adults having small lung or chest lining biopsies will be randomly assigned to have their tube removed early or stay overnight. The goal is to see if early removal reduces co…

This study tests whether adding a gentle electrical stimulation glove to standard therapy can improve hand and arm function in children aged 6-18 with hemiparesis (one-sided weakness). For 5 weeks, one group uses the glove at home for 30 minutes a day, 5 days a week, plus their u…

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and impro…

This study tests whether a structured shared decision-making approach helps patients with severe aortic stenosis choose between two valve replacement options: TAVR (less invasive) or SAVR (surgery). 140 patients aged 70 or older will be randomly assigned to either the structured …

This study looks at whether surgery can help people whose glioblastoma has come back after initial treatment. 120 participants will be randomly assigned to either have surgery followed by second-line therapy, or to have second-line therapy alone. The goal is to see if surgery imp…

This study tests whether a brain mapping technique called navigated transcranial magnetic stimulation (nTMS) can help doctors plan radiation therapy better for people with brain metastases near the motor cortex. About 30 patients who had surgery for a brain tumor will get both a …

This study tests a device to improve how doctors monitor brain function during surgery. It uses sensors and video to measure and minimize patient movement caused by electrical stimulation. The goal is to make brain surgery safer and more precise. About 200 patients with brain les…

This study looks at people with small intestinal neuroendocrine tumors that have spread and cannot be cured. It compares those who had surgery to remove the main tumor plus other treatments against those who had only other treatments. The goal is to see if surgery helps patients …

This study follows 2000 adults having planned bariatric surgery to learn what influences their pain and daily functioning afterward. Researchers will track pain levels, medication use, and long-term discomfort using patient questionnaires. The goal is to identify factors that lea…

This study tests whether injecting a small amount of fluid into the chest cavity during a CT-guided lung biopsy can lower the chance of lung collapse (pneumothorax). Researchers will also position patients so the biopsy is taken from the lowest part of the lung. About 198 adults …

This study looks at whether a new digital education and self-management program is practical and helpful for people with fibrotic interstitial lung disease. About 80 participants will use the program on their phone or computer during rehab or clinic visits. Researchers will measu…

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This study is gathering information from 1,500 adults with diabetes in Switzerland to see how well current treatments are working and how diabetes affects their health and daily life. Researchers will track complications, quality of life, and survival over time. The goal is to fi…

This study follows 400 women aged 40-60 to see if hormone replacement therapy (HRT) changes how often or how severely they get respiratory infections like colds or flu. Participants wear a smartwatch to track heart rate and sleep, and report symptoms daily. The goal is to underst…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who are getting a new heart valve (TAVI). One method is the usual invasive X-ray test; the other uses non-invasive risk management. The goal is to see which approach leads to be…

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see which genetic variations are linked to pain levels and painkiller use. The goal is to better understand and personalize p…

This study looks at small molecules called miRNAs in the blood of patients with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis, which can lead to more infections and higher risk of death. Researchers will compare miRNA patt…

This study compares brain aging in 200 healthy volunteers and people with multiple sclerosis using advanced MRI scans. Researchers aim to find patterns that predict how quickly the brain ages in MS. Participants undergo MRI and clinical assessments, but no treatment is given.

This study looks at whether low levels of immunoglobulin G (IgG), a type of antibody, are linked to fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue scores and infection rates between MS patients with low IgG and those with normal IgG. The goal is …

This study looks at whether adults with Glycogen Storage Disease Type I (GSDI) can safely eat foods with natural fruit sugars (fructose and galactose) without harming their metabolic control. Twenty adults will try a modified diet while researchers monitor key health markers like…

This study tests a questionnaire called QUOCCAS that parents and children fill out to see if it can spot kids with a higher chance of having an inherited cancer syndrome. About 205 children and teens with cancer will take part, giving a blood or saliva sample for genetic testing.…

This study looks at whether doing core muscle exercises right after abdominal surgery can change the chance of getting an incisional hernia or having long-term pain. About 588 adults having belly surgery will be split into two groups: one doing specific exercises and one getting …

This study is testing whether computer analysis of speech can reliably detect changes in movement, mood, and thinking in people with Parkinson's disease. Researchers will record and analyze voices from 80 participants while they perform tasks, aiming to find patterns linked to me…

This study is a registry that will enroll 816 adults with coronary artery disease. It compares two types of heart scans—CCTA and OCT—to see which one better identifies dangerous plaque and helps doctors plan treatment. The goal is to improve diagnosis and long-term outcomes, not …

This study looks at why some stroke survivors develop long-term pain called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with CPP. The goal is to better understand what causes this pain, which could lead to better t…

This study looks at 200 adults with rectal cancer who had chemoradiotherapy and then chose organ-preserving treatment. Some had a small local surgery to remove the scar, while others did not. Researchers will compare bowel, bladder, and sexual function between the two groups over…

This study watches 40,000 adults in European hospitals to see how often breathing tube problems happen during anesthesia. Researchers record patient details and any issues that come up, big or small. The goal is to learn from these events to make anesthesia safer for everyone in …

This study aims to make magnetic resonance spectroscopy (MRS) — a technique similar to MRI — more sensitive and reliable for measuring natural chemicals in the body. Researchers will test new methods in about 100 healthy volunteers, including during sleep or after exercise. The g…

This study looks at adults aged 18-70 who have a specific type of broken back (thoracolumbar burst fracture) but no nerve damage. Half will get surgery to fuse the spine, and half will wear a brace for six weeks instead. Researchers want to see if avoiding surgery works just as w…

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…