Centre Hospitalier Universitaire De Saint Etienne

This study aims to see if giving a 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever works as well and is as safe as giving it a month after they recover. It will involve over 1,000 adults who are at higher risk for serious pneumococcal infections and are …

This study is testing whether a combination of specially designed exercise and nutrition plans can help women with constitutional thinness gain muscle mass. Researchers will work with 62 women who have stable low weight but struggle to gain weight naturally. The program aims to i…

This study is testing a new nursing care model designed to improve how patients with stable chronic diseases manage their health. It involves 420 patients working in partnership with an Advanced Practice Nurse to co-create a personal care plan. The goal is to strengthen the patie…

This study is testing whether a new early identification program can reduce the time it takes for people experiencing their first psychotic episode to get specialized psychiatric care. The program works by educating the public and frontline workers (like doctors and teachers) abo…

This study aims to find the best treatment approach for Crohn's disease patients who initially responded to their medication but then stopped responding. Researchers will compare two options: increasing the dose of the current medication versus switching to a different type of me…

This study is testing whether using special monitors to guide the doses of anesthesia drugs during surgery can help prevent serious complications afterward. It will involve over 1,100 elderly patients who are at high risk for problems like kidney failure, heart issues, or deliriu…

This study is testing a program designed to help prostate cancer patients start and maintain regular physical activity. It combines personalized exercise plans, support from trained health professionals, and motivational coaching from fellow patients who have successfully stayed …

This study is for people with rheumatoid arthritis who are doing well on their medication and want to see if they can safely take less of it. Researchers will check the level of the drug in the blood to create a personalized plan for slowly reducing the dose. The goal is to help …

This study compares two surgical approaches for removing large, non-cancerous uteri: traditional laparoscopic surgery versus a newer vaginal endoscopic technique called vNOTES. Researchers aim to determine which method results in fewer complications during and after surgery. The …

This study is testing whether the drug rituximab can help control a rare and disabling nerve disease called Anti-MAG neuropathy. It will enroll 90 patients who have had the disease for a short time and have high levels of a specific antibody, as these patients are thought to be m…

This study aims to find a specific pattern of proteins in the blood that could help doctors diagnose a rare but serious lung disease called chronic thromboembolic pulmonary hypertension (CTEPH). Researchers will enroll 120 patients who are already scheduled for a heart catheteriz…

This study is creating and testing a short questionnaire to help doctors quickly screen for anxiety and depression in children and young adults who have survived childhood cancer. The goal is to make it easier to identify those who might need more support during their regular fol…

This study is testing if a simple, non-invasive treatment can prevent muscle weakness when a leg is immobilized. Healthy volunteers will have one leg immobilized for 10 days while receiving gentle muscle vibration therapy on that leg. Researchers will measure changes in leg stren…

This study tests whether magnetic stimulation of the brain can reduce chronic nerve pain in cancer patients. 60 participants with pain that hasn't responded well to medications will receive either real or fake (placebo) brain stimulation sessions. Researchers will compare pain re…

This study aims to see if a new, stricter protocol for managing medical monitor alarms in intensive care units (ICUs) can reduce noise pollution and improve patient safety. It will test if reducing the high number of false or unnecessary alarms—which can cause stress and slow dow…

This small pilot study is testing whether physical activity done outdoors in green spaces is more helpful for reducing certain persistent symptoms of schizophrenia than the same activity done indoors. It will involve 45 adults with schizophrenia who have these specific symptoms. …

This study is testing whether a personalized 6-month support program can help older adults feel stronger and recover better from surgery for bladder or kidney cancer. The program includes tailored exercise sessions and educational workshops, starting before surgery and continuing…

This study is testing if playing familiar music for people with Alzheimer's disease can help them fall asleep easier and be less agitated during the day. It involves 120 residents in specialized care homes, where caregivers will play music after meals. Researchers will use wrist-…

This study is testing whether adding a foam pad to a standard lower back support belt makes it more comfortable to wear. Researchers are enrolling 15 healthy volunteers to try the belt with and without the extra pad. They will rate their comfort and use special scans to see if th…

This study is testing whether adding a muscle vibration therapy to standard rehabilitation helps people recover walking ability after a recent stroke. Researchers will compare a group receiving real vibrations on their ankle muscles to a group receiving fake vibrations. The main …

This study aims to better understand skin damage that can occur in Wilson's disease patients taking the standard medication D-Penicillamine. Researchers will compare skin elasticity in 120 patients taking this medication against healthy volunteers using silicone molds and laser m…

This study aims to identify patients experiencing their first psychotic episode who are unlikely to respond to standard treatments. Researchers will use brain imaging scans from 80 participants to find markers that predict poor treatment response at three months. The goal is to h…

This study aims to understand how the time of day you exercise affects your deep sleep and body temperature. It will compare morning workouts to late afternoon workouts in two groups: endurance athletes and inactive people. Researchers want to see if afternoon exercise raises bod…

This study aims to understand how stroke patients with limb weakness process different types of feedback during mental movement exercises. Researchers will measure brain activity in 38 participants as they imagine moving while receiving visual cues, body-position cues, or a mix o…

This study compares how well a common blood thinner (apixaban) prevents blood clots in two groups: patients newly diagnosed with multiple myeloma (a blood cancer) and patients undergoing total knee replacement surgery. Researchers want to understand if the medication works differ…

This study aims to understand how type 1 diabetes affects the nervous system's control of the heart in children. Researchers will compare 24-hour heart rate patterns in 100 children with diabetes against healthy children of the same age and sex. The goal is to see if longer diabe…

This study aims to understand if newer, more detailed bone scans can better predict who is at risk for fractures compared to standard scans. It will enroll 1000 people with conditions that weaken bones, like osteoporosis, arthritis, kidney disease, and Parkinson's, as well as a c…

This study is looking for a better way to predict which cancer patients might have serious bleeding while taking blood thinners for a clot. Researchers will measure a specific blood test (thrombin generation) in 212 patients with cancer and a recent blood clot. They will see if t…