Centre Hospitalier Universitaire De Saint Etienne

This study looks at whether giving the 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever is as effective and safe as waiting until they are well. About 1052 adults with certain health risks (like heart or lung disease) will take part. The goal is to see if…

This study tests whether a purine-rich diet can lower disease markers in people with AICA-ribosiduria, a rare genetic condition causing severe disability and epilepsy. Ten participants will follow a diet with 160 mg of purines per day. Early results in one patient showed promise,…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study tests whether hydroxychloroquine, a drug already used for lupus, can slow kidney function decline in people with IgA nephropathy (Berger's disease). About 334 adults with biopsy-confirmed IgA nephropathy and high protein in their urine will receive either hydroxychloro…

This phase 3 trial tests whether rituximab, a drug that targets certain immune cells, can improve daily function in people with anti-MAG neuropathy, a rare nerve condition that causes progressive disability. The study will enroll 90 participants who have had the disease for 5 yea…

This study tests whether a tailored rehabilitation program, guided by monthly check-ups from a physiotherapist, can lower the chance of re-tearing the ACL or injuring the other knee after surgery. About 432 competitive athletes who want to return to sports like soccer or basketba…

This study looks for the best way to treat people who have a blood clot (like in the leg or lung) and also take daily aspirin or similar drugs for heart disease. Both conditions need blood thinners, but taking them together raises the risk of dangerous bleeding. The trial will co…

This study tests whether a program of adapted physical activity combined with extra nutrition can help women with constitutional thinness gain lean body mass (muscle). Constitutional thinness is a condition where people are naturally very thin and find it hard to gain weight, eve…

This study tests a program that helps prostate cancer patients become more physically active. It combines a personalized exercise plan, coaching from a fellow patient who is already active, and support from a doctor. The goal is to see if this approach helps men stay active long-…

This study tests a personalized approach to slowly reduce the dose of the biologic drug adalimumab in people with rheumatoid arthritis who are in remission. The goal is to find the best blood level of the drug before each dose reduction to lower the risk of disease flares. 180 ad…

This study looks at people with Crohn's disease whose current medicine (adalimumab) is no longer controlling their symptoms. It compares two options: increasing the dose of adalimumab or switching to a different drug called vedolizumab. The goal is to see which approach leads to …

This study tests whether closely monitoring the amount of sedation and pain medication given during surgery can prevent serious complications like kidney injury, heart problems, and death. It involves 1,132 high-risk patients over 75 or with conditions like heart disease. The goa…

This study aims to create a short, simple questionnaire that doctors can use during routine check-ups to quickly screen childhood cancer survivors for anxiety and depression. About 545 participants aged 6 to 25 who have finished intensive cancer treatment and are in remission wil…

This study aims to find specific protein patterns in the blood that can help doctors diagnose chronic thromboembolic pulmonary hypertension (CTEPH), a rare but serious lung condition that can follow a blood clot in the lungs. Researchers will analyze blood samples from 120 people…

This study is testing whether a simple urine sample can work as well as the standard cervical swab for detecting HPV, the virus that causes almost all cervical cancers. The goal is to make screening easier and more comfortable, especially for women who avoid the current test. Abo…

This study is testing a new, non-invasive urine test to detect clear cell renal cell carcinoma, a common type of kidney cancer. Currently, diagnosis often requires expensive imaging or a painful biopsy. Researchers are looking for tiny particles called exosomes in urine that are …

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with virtual reality mirror therapy can reduce neuropathic pain that hasn't responded to drugs. Sixty-four adults with moderate to severe nerve pain for at least six months will receive rTMS pl…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic nerve pain caused by cancer or its treatment. Sixty adults with moderate-to-severe pain will receive both real and placebo (sham) stimulation in random order, with an 8-wee…

This study tests whether adding gentle vibrations to the leg muscles can help people recovering from a stroke walk faster. About 70 patients who had a stroke within the past 3 months will either get real vibrations or a fake treatment during their regular rehab. The goal is to se…

This study looks at whether adding a foam pad to a standard lumbar belt improves comfort for healthy adults and people with low back pain. Researchers will measure comfort on a scale from 0 to 10. The goal is to see if a small change can make wearing the belt more pleasant.

This study tests whether playing familiar music in the bedroom before bedtime can help people with Alzheimer's fall asleep faster, sleep longer, and feel less agitated during the day. Researchers will use a wrist monitor (actigraphy) to track sleep and behavior in 120 participant…

This study tests a personalized 6-month program for older adults being treated for bladder or kidney cancer. The program includes exercise sessions and educational workshops before and after surgery. The goal is to see if it can reduce frailty, measured by how far patients can wa…

This study tests three non-drug programs—exercise alone, exercise plus acupuncture, and exercise plus nerve stimulation—to see which best reduces fatigue in people with Sjögren's syndrome. About 174 adults with long-term fatigue will be randomly assigned to one of the programs or…

This study tests whether physical activity in green outdoor spaces reduces negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. 45 adults aged 18-55 with persistent negative symptoms will participate. Researchers…

This study compares a new surgical technique called vNOTES (scarless vaginal surgery using a tiny camera) to standard laparoscopic hysterectomy in 200 women with large uteri (over 280 grams). The goal is to see if vNOTES reduces complications like infections, bleeding, or organ i…

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study looks at whether longer or shorter training sessions help healthy adults maintain their endurance during a 4-hour cycling test. Researchers will measure changes in power output and heart rate. 40 volunteers who exercise up to 2 hours per week will participate.

This study tests a new way to manage alarms in intensive care units (ICUs). Currently, patients trigger hundreds of alarms each day, but most are false or not important. The goal is to see if a stricter alarm protocol can reduce noise and still keep patients safe. About 514 adult…

This study tests whether a small vibrating device placed on the thigh can prevent muscle loss and weakness in healthy adults during a period of reduced activity. 42 participants will have one leg immobilized and either receive focal muscle vibration or no treatment. The goal is t…

This study aims to understand how and why humans make nonverbal sounds such as screams, grunts, and laughter. Researchers will record and analyze these vocalizations from 2,000 participants, measuring acoustic features like pitch and roughness, along with physiological responses …

This study looks at whether a short, intense program of local vibration (5 days) can improve leg muscle strength as much as a longer program (4 weeks). 72 healthy adults will try different vibration session lengths (30 or 60 minutes). The goal is to find the most efficient way to…

This study looks at how genes and symptoms are linked in Fuchs' corneal endothelial dystrophy, a common eye disease that affects the cornea. Researchers will analyze DNA from 500 people who need cornea surgery to find patterns that may explain why the disease looks different in d…

This study looks at how the blood thinner apixaban works in two groups of people at risk for blood clots: those with newly diagnosed multiple myeloma and those recovering from total knee replacement. Researchers want to see if the drug affects clotting differently in myeloma pati…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study tests a program called PRESTO that helps people spot early signs of first-episode psychosis and get specialized care faster. The goal is to shorten the time someone goes without treatment, which may lead to better long-term results. About 416 participants will take par…

This study looks at how the timing of aerobic exercise—morning versus late afternoon—affects deep sleep and body temperature. Researchers will compare endurance athletes with inactive people to see who is more affected. The goal is to understand how exercise timing can improve sl…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study is testing a new way to measure fatigue in people with spinal muscular atrophy (SMA), a condition that causes muscle weakness. The test is designed to be easy enough for patients with different levels of ability. Researchers want to see if the test is safe, doable, and…

This study looks at whether polishing the inner layer of the cornea before injecting new cells helps remove tiny bumps called guttae in people with Fuchs endothelial corneal dystrophy. Twenty adults scheduled for corneal transplant will have half their cornea polished and the oth…

This study looks at how stroke patients with weakness on one side use visual and touch feedback when imagining movements. Researchers will record brain activity with EEG while patients perform mental tasks. The goal is to understand how different parts of the brain handle these s…

This study is looking for a better way to track disease activity in people with primary Sjögren's syndrome, a chronic autoimmune disease that causes dryness and can affect organs. Researchers will test a new blood marker called anti-Ro/SSA IgE in 185 participants to see if it is …

This study looks at how hearing sounds like screams, laughter, or crying affects people's thoughts and physical reactions. Researchers will play these sounds to 2000 healthy adults and measure things like heart rate, skin temperature, and how fast they respond. The goal is to bet…

This study looks at whether brain imaging can help predict which people having a first psychotic episode will not get better after 3 months of standard treatment. Researchers will follow 80 people aged 18-35 with a first episode of schizophrenia or related disorders who have neve…

This study is testing a new device called ADHELASKIN to see if it can measure skin stiffness more accurately than the current method (feeling the skin by hand) in people with systemic sclerosis (scleroderma). The study will compare 100 participants: those with scleroderma and hea…

This study looks at how type 1 diabetes affects the nerves that control heart rate and breathing in children. Researchers will measure heart rate variability in 100 children (50 with diabetes and 50 healthy) to detect early signs of nerve damage. The goal is to better understand …

This study tests three ways of combining mental practice of movement with tendon vibration in 33 healthy adults aged 18-50. The goal is to see which method best activates brain areas involved in movement. Results will help design better rehabilitation for people who cannot move n…

This study aims to create better custom insoles for people with rheumatoid arthritis who have foot pain. Researchers will use CT scans and motion analysis to build a digital model of how feet move and apply pressure. The goal is to design insoles that reduce pain and improve comf…

This study looks at how a common Wilson's disease medication, D-Penicillamine, affects the skin. Researchers will measure skin elasticity in 120 people—some with Wilson's disease taking the drug and some healthy volunteers. The goal is to better understand the skin damage caused …

This study aims to see if completely inactive people can train for 18 months to complete a 100 km mountain ultra-marathon. Researchers will track how many participants stick with the program and finish the race, as well as monitor injuries and overall health. The goal is to under…