Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests whether using lung ultrasound to personalize ventilator settings can reduce deaths in patients with acute respiratory distress syndrome (ARDS). About 538 adults on breathing machines will be assigned to either standard care or a personalized approach guided by ul…

This study tests whether starting strong cholesterol-lowering therapy early can reverse plaque buildup in the arteries of young adults (ages 18-50) with familial hypercholesterolemia, a genetic condition causing very high cholesterol. Researchers will use CT scans to measure chan…

This study tests whether a drug-coated balloon can reduce fatty buildup in heart artery plaques better than standard medications alone. Researchers will enroll 400 adults with acute coronary syndrome. Participants will be randomly assigned to receive either the balloon treatment …

This study is testing a procedure called duodenal mucosal resurfacing (DMR) to see if it can safely improve blood sugar control in people with type 2 diabetes who are not on insulin. About 18 adults will be randomly assigned to receive DMR or a sham (fake) procedure. The study wi…

This study tests a personalized approach to monitor and treat polyps in the stomach and duodenum of people with familial adenomatous polyposis (FAP), a genetic condition that raises cancer risk. Researchers will enroll 1,000 adults with FAP to see if tailored surveillance and end…

This study tests a one-time, focused radiation treatment for people with ventricular tachycardia (a dangerous fast heart rhythm) that hasn't been controlled by medication or standard procedures. The treatment aims to reduce the number of episodes by at least half over a year. The…

This study tests whether using heat (radiofrequency ablation) to destroy cancer tissue inside the bile duct before placing a metal stent can keep the duct open longer than placing a stent alone. It involves 122 adults with inoperable bile duct cancer. The main goal is to see how …

This study tests a procedure called bronchial thermoplasty (BT) for adults with severe asthma that remains uncontrolled even with biologic drugs. BT uses a thin tube to deliver heat to the airway walls, aiming to reduce muscle overreactivity. Researchers will compare asthma attac…

This study looks at people with esophageal or stomach cancer that has spread to only a few spots (oligometastases). All participants get 4 months of standard therapy, then are randomly assigned to either 4 more months of drugs before local treatment (surgery or radiation) or imme…

This study is for people with familial adenomatous polyposis (FAP) who have had their colon removed. It tests a personalized plan to regularly check and treat any new polyps in the remaining bowel. The goal is to keep the risk of advanced polyps or cancer very low (under 5% over …

Some people with long COVID have symptoms like extreme fatigue because their immune system attacks their own body. This study tests a treatment called immunoadsorption, which filters the blood to remove harmful antibodies. About 70 adults with long COVID and these antibodies will…

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study tests whether using lung ultrasound to guide removal of extra fluid helps patients on breathing machines in the ICU breathe on their own sooner. About 1,000 adults who need a ventilator for at least another day will be randomly assigned to have fluid removal guided by …

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests a shorter, more intense radiation schedule combined with chemotherapy for people with locally advanced esophageal cancer. The goal is to see if this approach is safe and feasible, and to reduce side effects like low white blood cell counts. About 60 adults will r…

This study tests whether ziltivekimab, an anti-inflammatory drug, can reduce swelling in the heart's arteries. About 40 adults with heart disease and high inflammation will receive either the drug or a placebo. Researchers will use special scans and blood tests to see if the drug…

This study tests if people with well-controlled eczema can safely take their dupilumab injections less often. 216 adults will be randomly assigned to receive the drug every 2, 3, or 4 weeks. Researchers will compare eczema severity and quality of life to see if longer intervals w…

This trial tests whether giving three treatments together—two medicines and a surgical patch—can lower the risk of major complications after Whipple surgery for pancreatic cancer and other tumors. The study includes 400 high-risk patients with a small pancreatic duct. If successf…

This study tests whether a rapid blood test called presepsin can safely reduce unnecessary antibiotic use in very preterm babies (born before 32 weeks). Currently, over 85% of these infants get antibiotics right after birth due to infection risk, but only about 1 in 70 actually h…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that can perform a specialized clot-remov…

This study compares two ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease: adaptive DBS, which adjusts stimulation in real time based on brain signals, and continuous DBS, which delivers constant stimulation. About 130 adults who already have a DB…

This study looks at whether a program of exercise and dietary changes can improve or maintain quality of life for people with incurable stomach or esophageal cancer. Researchers will compare two groups of about 196 patients: one group receives standard care, and the other adds a …

This study tests whether fluvoxamine, an antidepressant, can reduce severe fatigue and other symptoms in people with post-COVID. 160 adults aged 18-70 with long-lasting fatigue after COVID will receive either the drug or a placebo for 12 weeks. The goal is to see if it improves e…

This study tests whether using virtual reality (VR) to simulate the workplace helps cabin crew on sick leave for mental health issues return to work sooner. 118 participants will either get standard care or standard care plus at least one VR session. The goal is to see if VR redu…

This study looks at whether keeping low- and intermediate-risk fainting patients in the hospital for 24 hours with a heart monitor is better than sending them home right away. About 640 adults will be randomly assigned to either stay or go home. The goal is to see if the longer m…

People with type 2 diabetes are at high risk for heart disease. This study will follow 1,000 such patients who have already had a heart CT scan. Researchers will repeat the scan and track how plaque buildup in the heart's arteries changes over time. The goal is to better understa…

This study tracks 1,000 women and men having heart surgery to see how a condition called left ventricular diastolic dysfunction (LVDD) affects their recovery. LVDD makes it harder for the heart to relax and fill with blood. Researchers will compare outcomes like complications and…

This study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with non-cancerous growths. About 256 adults will be randomly assigned to one of the two procedures. The goal is to see which approa…

This study aims to understand why Crohn's disease often returns after surgery by examining specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 patients with Crohn's disease during routine colonoscopies, before and after 12…

This study looks at how the liver reacts to a sugar injection during bariatric surgery in people with obesity, comparing those with and without fatty liver disease (MASLD). Forty adults will receive either a sugar solution or salt water during surgery, and small tissue samples wi…

This study looks at whether using a tilt-table test can help people who faint due to vasovagal syncope. 238 adults will be randomly assigned to receive biofeedback training either with or without a tilt-table test. The goal is to see if the test reduces how often fainting happens…

This study looks at whether measuring a different thyroid hormone (fT3) or the ratio of two hormones (fT3/fT4) can give a clearer picture of thyroid health in people taking levothyroxine. It includes 500 adults with various types of hypothyroidism who are on a stable dose of the …

This study follows over 3,000 people with low-risk Barrett's esophagus who have stopped having routine endoscopic surveillance, as recommended by new guidelines. Researchers will track them for at least 10 years to see if stopping these scopes leads to a rise in serious esophagea…

This study looks at whether removing the spleen during surgery for left-sided pancreatic cancer is always necessary. Currently, the spleen is taken out to remove any hidden cancer cells in the surrounding fat, but this can cause extra risks. By checking how often cancer actually …

This study observes 150 ICU patients who need excess fluid removed. Researchers will track how fast and when fluid is removed, and look for signs of success or side effects like low blood pressure. The goal is to find safer, more personalized fluid removal methods, but this study…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…