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Spleen-saving surgery for pancreatic cancer under study

NCT ID NCT07157605

Knowledge-focused Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study looks at whether the spleen can be safely left in place during surgery for left-sided pancreatic cancer. Currently, the spleen is removed as a standard part of the operation to ensure any cancer in the surrounding fat is also taken out. The study will check how often cancer actually spreads to the spleen area in 94 patients, to see if keeping the spleen might be a safe option in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the risk of cancer spread to the spleen area is low, this could lead to a change in standard surgery, allowing more patients to keep their spleen.
What could go wrong
This is an observational study with only 94 patients, so results may not apply to everyone. It is a first step and does not yet prove that spleen preservation is safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 94 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Jan 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients from hospitals performing pancreatic surgery

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All consecutive adult patients (≥ 18 years) who undergo an open or minimally invasive (i.e., robot-assisted or laparoscopic) left-sided pancreatectomy with concomitant splenectomy for primary resectable, borderline resectable, and locally advanced left-sided PDAC Exclusion Criteria: * Tumor involvement or abutment of the spleen

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pancreatectomy Pancreatic cancer resectable

Contacts and locations

Locations

  • Amsterdam UMC

    Amsterdam, Netherlands

  • BenQ Hospital

    Nanjing, China

  • Dr. Peset University Hospital

    Valencia, Spain

  • Konstantopoulio General Hospital

    Athens, Greece

  • Kyushu University Hospital

    Fukuoka, Japan

  • Leiden University Medical Center

    Leiden, Netherlands

  • Linköping University Hospital

    Linköping, Sweden

  • OLVG Hospital

    Amsterdam, Netherlands

  • Oslo University Hospital

    Oslo, Norway

  • Padova University Hospital

    Padova, Italy

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