Aggressive cholesterol drugs may shrink artery plaque in young patients
NCT ID NCT05783804
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 33 times
Summary
This study tests whether starting strong cholesterol-lowering therapy early can reverse plaque buildup in the arteries of young adults (ages 18-50) with familial hypercholesterolemia, a genetic condition causing very high cholesterol. Researchers will use CT scans to measure changes in plaque volume over time. The goal is to see if aggressive treatment can stop or even reverse artery disease progression.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Amsterdam UMC, location AMC
RECRUITINGAmsterdam, North Holland, 1105 AZ, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lipid-lowering therapy (statins and/or other cholesterol drugs)
What this could lead to
If it works, this could show that early aggressive treatment can reverse artery plaque buildup, potentially reducing heart attack risk in young people with this genetic condition.
What could go wrong
This is a small early-phase study with only 60 participants, so results may not apply to everyone. Plaque reversal may be modest or not occur, and aggressive lipid-lowering carries risks like muscle pain or liver issues.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.