Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took either the drug combo or a placebo in cycles ove…

This study tested a personalized approach using custom-made shoes and inserts to prevent foot ulcers from returning in people with diabetes. 126 adults with a history of foot ulcers were followed for 12 months. The goal was to see if this tailored approach could reduce ulcer recu…

This study tested whether a personalized breathing machine setting during open abdominal surgery could prevent lung complications like pneumonia or respiratory failure. Over 1,400 patients at risk for lung problems were randomly assigned to either the personalized strategy or sta…

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic condition causing inflammation in the colon. 85 participants received either donor or their own stool via tubes and enemas. The goal was to see if donor transplant…

This study looked at 410 people with a bile duct infection (cholangitis) who had successful drainage of the bile duct. It compared a very short course of antibiotics (1 day) to the usual longer course (4 to 7 days) to see if the short course was just as good at curing the infecti…

This study tested whether giving sickle cell patients two drugs (azathioprine and hydroxyurea) for three months before a stem cell transplant could help the transplant work better. Twenty adults with a matched sibling donor took part. The goal was to see if this approach could re…

This study combined data from nearly 4,000 stroke patients to see how often a heart CT scan finds blood clots that standard ultrasound might miss. Researchers looked at how well this quick scan, done during the initial stroke workup, detects clot sources in the heart. The goal is…

This pilot study tested a plastic stent with a retrieval string to drain bile in 40 people with resectable bile duct cancer. The goal was to see if the stent could safely reduce bile buildup before surgery. Researchers measured serious complications and how well the stent worked.

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, …

This study tested a technique called cold snare to collect larger pieces of tissue from the duodenum during a routine endoscopy. Researchers wanted to see if these samples were good enough for detailed analysis, including single cell RNA sequencing. The study involved 13 people a…

This study brought together 35 healthcare experts from around the world to agree on the best ways to clear mucus from the airways of critically ill patients who are on breathing machines. The goal was to create clear, shared guidelines for treatments like humidification, inhaled …

This study looks at whether people who have been bitten many times by ticks can develop a natural resistance. Researchers placed uninfected ticks on 24 volunteers — some with a history of tick bites, some without — and measured how well the ticks fed. The goal is to understand if…

This study observed over 2,500 critically ill patients on breathing machines in intensive care units worldwide. Researchers tracked how doctors used fluids and blood pressure medicines, and looked for links to patient outcomes like length of stay and survival. The goal was to und…

This study looked at whether it is safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD), a device that shocks the heart back to normal rhythm during dangerous arrhythmias. About 965 adults who needed an S-ICD were rand…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This study followed over 1,100 high-risk COVID-19 patients in the Netherlands who received new antiviral drugs or monoclonal antibodies. Researchers collected blood samples and nasal swabs over 90 days to see how the virus and the body's immune response changed during treatment. …

This study tested whether humans can develop immunity to tick bites by repeatedly exposing 11 volunteers to uninfected ticks. Researchers measured tick feeding, molting, and survival, along with signs of immune response like itching and redness. The goal is to lay groundwork for …

This study tested a new way of helping patients breathe during a procedure that destroys liver tumors with heat or electricity. The new method, called flow-controlled ventilation, keeps the diaphragm more still than standard methods, which could help doctors place needles more ac…

This study looked at how long it takes for a key stress hormone (cortisol) and its carrier protein to return to normal after healthy women stop taking combined oral contraceptive pills. Twenty-four women were followed for several weeks after stopping the pill. The goal was to und…

This study tested whether an automated device called FlowSure can measure urine output more accurately than the usual manual method in hospital patients with a urinary catheter. 75 adults took part, and their urine was monitored over 8- and 24-hour periods. The goal was to see if…

This study looked at the brain's central clock in 28 people with different stages of insulin resistance, including those with type 2 diabetes. Using advanced MRI scans, researchers measured how the brain clock responds to light. The goal was to understand if a disrupted brain clo…