Custom ventilation during surgery may cut lung risks
NCT ID NCT03884543
First seen Nov 19, 2025 · Last updated Jun 21, 2026 · Updated 33 times
Summary
This study tested whether a personalized breathing machine setting during open abdominal surgery could prevent lung complications like pneumonia or respiratory failure. Over 1,400 patients at risk for lung problems were randomly assigned to either the personalized strategy or standard care. The approach aimed to keep the lungs open with the least pressure needed.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Amsterdam, Netherlands
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Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
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Amsterdam UMC location VUmc
Amsterdam, Netherlands
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Bermanntrost BG Klinikum Halle
Halle, Germany
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Bernhoven Hospital
Uden, Netherlands
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Erasmus Medisch Centrum
Rotterdam, Netherlands
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HAGA
The Hague, Netherlands
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Haaglanden Medisch Centrum
The Hague, Netherlands
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Heinrich-Heine University Hospital Dusseldorf
Düsseldorf, Germany
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Leiden UMC
Leiden, Netherlands
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Maastricht UMC
Maastricht, Netherlands
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Martini Hospital
Groningen, Netherlands
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Medical Center Leeuwarden
Leeuwarden, Netherlands
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Noordwest ziekenhuizengroep Alkmaar
Alkmaar, Netherlands
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Onze Lieve Vrouwen Gasthuis
Amsterdam, Netherlands
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Ospedale Policlinico San Martino
Genoa, Italy
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Radboud UMC
Nijmegen, Netherlands
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Rijnstate Hospital
Arnhem, Netherlands
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Spaarne Gasthuis Hospital
Haarlem, Netherlands
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UMC Groningen
Groningen, Netherlands
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University hospital Carl Gustav Carus
Dresden, Germany
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University hospital Napoli
Naples, Italy
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
individualized high PEEP ventilation strategy
What this could lead to
If successful, this could lead to a standard way to ventilate patients during open abdominal surgery to reduce lung complications.
What could go wrong
This trial is completed but results may not apply to all surgeries or patients. The strategy involves adjustments that may not work for everyone.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.