Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests a treatment called immunoadsorption for people with long COVID who have certain antibodies. The treatment filters the blood to remove these antibodies, which may be causing symptoms like extreme fatigue. About 70 participants will receive either the real treatmen…

This study tests a procedure called bronchial thermoplasty (BT) for adults with severe asthma that still causes attacks despite using biologics or other standard treatments. BT uses a thin tube to deliver heat to the airways to reduce muscle overreactivity. The study will compare…

This study tests a personalized monitoring and treatment plan for 1000 people with familial adenomatous polyposis (FAP) who have had their colon removed. The goal is to see if tailored check-ups can keep the rate of advanced polyps or cancer below 5% over 5 years. Participants wi…

This study tests a personalized approach to monitor and treat polyps in the stomach and duodenum of people with Familial Adenomatous Polyposis (FAP), a genetic condition that raises cancer risk. Researchers will follow 1,000 adults with FAP to see if tailoring the timing and type…

This study tests whether adding a blood test (presepsin) to standard care can safely reduce unnecessary antibiotics in premature babies born before 32 weeks. Many of these infants receive antibiotics right after birth due to infection risk, but only 1 in 70 actually has an infect…

This study tests whether using lung ultrasound to guide the removal of extra fluid helps patients on breathing machines in the ICU get off the ventilator sooner. About 1,000 adults who are expected to need a ventilator for more than 24 hours will be randomly assigned to either ul…

This study looks at whether giving young adults (under 50) with inherited high cholesterol strong cholesterol-lowering drugs early can shrink plaque in their arteries. Researchers will use CT scans to measure plaque changes over time. The goal is to see if aggressive treatment ca…

This study tests whether using lung ultrasound to customize breathing machine settings can lower the death rate in patients with acute respiratory distress syndrome (ARDS), a severe lung condition. About 538 adults on ventilators will be assigned to either standard care or ultras…

This study tests whether giving a combination of two medicines (hydrocortisone and octreotide) plus using a patch made from the patient's own tissue can lower the risk of major complications after Whipple surgery for pancreatic cancer. The trial includes 400 high-risk patients wh…

This study compares two ways of using deep brain stimulation (DBS) for Parkinson's disease: standard continuous stimulation versus a newer adaptive version that adjusts in real time. About 130 adults who already have a DBS implant will be randomly assigned to one of the two metho…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This study tests if using virtual reality (VR) can help flight cabin crew return to work faster after taking sick leave for mental health issues like stress or anxiety. About 118 participants will either get standard care or standard care plus at least one VR session where they v…

This study looks at whether removing the spleen during left-sided pancreatic cancer surgery is always necessary. Currently, the spleen is removed to catch any hidden cancer cells in the surrounding fat, but this adds risks. By observing 94 patients, researchers hope to find out i…

This study looks at whether a tilt-table test, combined with biofeedback training, can reduce fainting in people with vasovagal syncope. About 238 adults will be randomly assigned to receive biofeedback with or without the tilt-table test. The goal is to see if the test helps low…

This study will collect data from 3000 people receiving a special drug-coated balloon to open blocked heart arteries. Researchers want to see how well the balloon works in everyday practice, including for different types of blockages and in patients with stable or unstable heart …

This study follows 1,000 adults with type 2 diabetes who have already had a heart CT scan. Researchers will repeat the scan to see how fatty plaque in the heart arteries changes over time. The goal is to better understand who is at highest risk for heart attacks and other problem…

This study looks at people who come to the emergency room after fainting and are at low or medium risk for serious problems. Half will stay in the hospital for 24 hours with heart monitoring, and half will go home right away. The goal is to see if the longer stay helps find hidde…