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Birth control pill withdrawal: how long until hormones normalize?

NCT ID NCT06802211

Knowledge-focused Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how long it takes for a key stress hormone (cortisol) and its carrier protein to return to normal after healthy women stop taking combined oral contraceptive pills. Twenty-four women were followed for several weeks after stopping the pill. The goal was to understand the timing of hormone recovery, which can help doctors interpret lab results and guide care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

24 people

The number who actually took part.

Started

Feb 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult females who are planning to discontinue estrogen containing oral contraceptives for a duration of at least 6 weeks.

Ages

18 years and older

Sex

Female participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years old * Using oral combined contraceptives of any kind and dosage * Planning to stop COC use shortly for at least 6 weeks (out of own reasons such as a pregnancy wish or choice for non-hormone based contraceptives) * COC use for at least 3 consecutive weeks before the discontinuation * Ability to provide informed consent * Ability to speak and understand Dutch Exclusion Criteria: * Switching to other hormonal contraceptives after taking the COC pill (e.g. progesterone containing contraceptives such as the Mirena IUD, contraceptive implants) directly after the discontinuations * Contra-indications to quit COC * Biological factors that affect CBG concentrations, including: * Illnesses interfering with CBG levels (severe liver or kidney disease, active malignancy, hyperthyroidism) * Use of insulin, systemic exogenous glucocorticoids, mitotane, selective estrogen receptor modulators (SERMs) * Pregnancy during study period after discontinuation of COCs

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Combined oral contraceptive cessation

Contacts and locations

Locations

  • Amsterdam UMC

    Amsterdam, 1105 AZ, Netherlands