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Can your body learn to fight off ticks? scientists investigate

NCT ID NCT07479537

Knowledge-focused Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether people who have been bitten many times by ticks can develop a natural resistance. Researchers placed uninfected ticks on 24 volunteers — some with a history of tick bites, some without — and measured how well the ticks fed. The goal is to understand if humans can develop acquired tick resistance, which could one day help create a vaccine that stops ticks from spreading diseases.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help design vaccines that target ticks themselves, potentially preventing multiple tick-borne diseases.
What could go wrong
This is a small observational study (24 people) that only measures tick feeding and skin reactions. It does not test any treatment, so results may not lead directly to a vaccine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Aug 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Naturally acquired self-reported tick resistant individuals: * Age: 18 - 70 years; * History of repeated tick bites * Local reaction (like redness or itch) at place of previous tick bites and/or signs of impaired tick feeding after bite (anamnestic) Controls: • Age: 18 years - 70 years; Experimentally acquired tick resistant individuals: * Previous participant in the TICK ME study that has completed all 4 challenges * Age: 18 years - 70 years; Exclusion Criteria: * Current suspicion of any tick-borne disease * Diagnosed with tick-borne disease within the last year * Chronic skin condition affecting the skin of the arm; * Inability to maintain the dressing for any reason; * Known immunodeficiency or autoimmune disease; * Use of systemic immunomodulating drugs or chemotherapy, current or in the past; * Chronic use of antibiotics; * Unable to give informed consent or do not have a thorough command of the Dutch language; * Refusal to participate in specimen collection and storage for future study related use; * Pregnant or breastfeeding women; * Not willing to use adequate contraception during the study period; * Red meat allergy (both medically confirmed and self-reported); * Use of investigational therapy and devices during the time of the study; * Any other condition that, in the opinion of the investigator, would make the patient unsuitable for enrolment or could interfere with the patient participating in and completing the study. Additional exclusion criteria for controls: * Known history of tick bites; * Positive Borrelia serology (VlsE1/PepC10 ELISA); * Known history or current suspicion on any tick-borne disease Additional exclusion criteria for experimentally acquired tick resistant individuals: * History of tick bites acquired outside of TICK ME study; * Positive Borrelia serology (VlsE1/PepC10 ELISA); * Known history or current suspicion on any tick-borne disease

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Conditions

The condition(s) this trial relates to.

Tick Bites

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tick bites Tick resistance

Contacts and locations

Locations

  • Amsterdam UMC

    Amsterdam, North Holland, 1105AZ, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.