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Could one day of antibiotics be enough for bile duct infections?

NCT ID NCT05750966

Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 410 patients with a bile duct infection (cholangitis) who had a procedure to drain the bile duct. It compared giving antibiotics for just 1 day versus the usual 4 to 7 days. The goal was to see if the shorter course is just as good at curing the infection, while possibly causing fewer side effects and shorter hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotics (e.g., ceftriaxone, gentamicin, ciprofloxacin)
What this could lead to
If successful, this could show that a very short course of antibiotics is enough after drainage, reducing side effects, hospital stays, and costs for patients with cholangitis.
What could go wrong
This is a completed trial, but results are not yet published. The shorter course might not work as well for all patients, especially those with more severe infections or underlying conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

410 people

The number who actually took part.

Started

Jul 2023

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with acute cholangitis due to common bile duct stones, benign or malignant distal biliary obstruction or distal biliary stent dysfunction (only stents in situ for a minimum of 30 days) * ERCP with adequate biliary drainage (all common bile duct stones are removed and/or there is adequate flow of clear bile with or without a biliary stent(s)) * Absence of fever (temperature \<38.5°C) or a decrease of body temperature of at least 1°C has occurred within 24 hours after ERCP * Age ≥ 18 years * Written informed consent (IC) Exclusion Criteria: * Other aetiologies of acute cholangitis (e.g. primary sclerosing cholangitis, (sub)hilar and/or intrahepatic strictures or hilar stents) * A recurrent cholangitis (within 3 months) * Patients with surgically altered anatomy (leading to biliary-enteric anastomosis) * Concomitant pancreatitis, according to International Association of Pancreatology/American Pancreatic Association guidelines.\[18\] Acute pancreatitis is diagnosed in case of fulfilment of 2 out of 3 of the following criteria: * Upper abdominal pain * Serum amylase or lipase \>3x ULN * Signs of acute pancreatitis on imaging * Concomitant cholecystitis, according to TG18 criteria.\[19\] Acute cholecystitis is suspected in case one item in A is met and one item in B and C. A. Local signs of inflammation * A1: Murphy's sign * A2: Right upper quadrant mass/pain/tenderness B. Systemic signs of inflammation * B1: Fever * B2: Elevated C-reactive protein * B3: Elevated WBC count C. Imaging findings characteristic of acute cholecystitis * Concomitant liver abscess * Another additional infectious diagnosis * Admission on an Intensive Care Unit (ICU) at time of randomisation * Use of maintenance antimicrobial therapy * Use of immunosuppressants * Neutropenia

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Conditions

The condition(s) this trial relates to.

acute cholangitis cholangitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cholangitis

Contacts and locations

Locations

  • Albert Schweitzer Ziekenhuis

    Dordrecht, South Holland, 3318 AT, Netherlands

  • Alrijne Ziekenhuis

    Leiderdorp, South Holland, 2353 GA, Netherlands

  • Amstelland Ziekenhuis

    Amstelveen, North Holland, 1186 AM, Netherlands

  • Amsterdam UMC

    Amsterdam, North Holland, 1081 HZ, Netherlands

  • Canisius Wilhelmina Ziekenhuis

    Nijmegen, Gelderland, 6532 SZ, Netherlands

  • Catharina Ziekenhuis

    Eindhoven, North Brabant, 5623 EJ, Netherlands

  • Deventer Ziekenhuis

    Deventer, Overijssel, 7416 SE, Netherlands

  • Dijklander Ziekenhuis

    Hoorn, North Holland, 1624 AR, Netherlands

  • Elisabeth Tweesteden Ziekenhuis

    Tilburg, North Brabant, 5022 GC, Netherlands

  • Erasmus MC

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Flevoziekenhuis

    Almere Stad, Flevoland, 1315 RA, Netherlands

  • Groene Hart Ziekenhuis

    Gouda, South Holland, 2803 HH, Netherlands

  • Haaglanden Medisch Centrum

    The Hague, South Holland, 2512 VA, Netherlands

  • Isala

    Zwolle, Overijssel, 8025 AB, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands

  • Leids Universitair Medisch Centrum

    Leiden, South Holland, 2333 ZA, Netherlands

  • Maasstad Ziekenhuis

    Rotterdam, South Holland, 3079 DZ, Netherlands

  • Maastricht UMC+

    Maastricht, Limburg, 6229 HX, Netherlands

  • Martini Ziekenhuis

    Groningen, Provincie Groningen, 9728 NT, Netherlands

  • Meander MC

    Amersfoort, Utrecht, 3813 TZ, Netherlands

  • Medisch Centrum Leeuwarden

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Medisch Spectrum Twente

    Enschede, Overijssel, 7512 KZ, Netherlands

  • OLVG

    Amsterdam, North Holland, 1091 AC, Netherlands

  • Radboud umc

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Reinier de Graaf Gasthuis

    Delft, South Holland, 2625 AD, Netherlands

  • Rijnstate Ziekenhuis

    Arnhem, Gelderland, 6815 AD, Netherlands

  • Spaarne Gasthuis

    Hoofddorp, North Holland, 2134 TM, Netherlands

  • St. Antonius Ziekenhuis

    Nieuwegein, Utrecht, 3435 CM, Netherlands

  • Universitair Medisch Centrum Groningen

    Groningen, Provincie Groningen, 9713 GZ, Netherlands

  • Universitair Medisch Centrum Utrecht

    Utrecht, Utrecht, 3584 CX, Netherlands

  • Zaans Medisch Centrum

    Zaandam, North Holland, 1502 DV, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.