NEOPLASMS

This study tests a new drug called pocenbrodib, either alone or with other treatments, in people with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The goal is to find the safest dose and see if it can shrink tumors or lower PSA levels. A…

This study tests a new drug called nenocorilant combined with an immunotherapy (nivolumab) in people with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 50 adults with v…

This early-phase study tests an experimental drug, JNJ-88549968, designed to help the immune system attack cancer cells with a specific genetic change (CALR mutation). About 220 adults with essential thrombocythemia or myelofibrosis will receive the drug to find a safe dose and c…

This study, called CAMPFIRE, is a master protocol that helps researchers test multiple new cancer drugs in children and young adults more efficiently. About 105 participants with different types of cancer will join, and each will receive a drug tailored to their disease. The goal…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This early-stage study is testing an experimental chemotherapy drug, JNJ-1761981, that is injected directly into tumors. The goal is to find a safe and effective dose for people with advanced solid tumors who have not responded to standard treatments. The study will monitor side …

This study tests the drug vorolanib in people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after the first one stopped working. The goal is to see how long the drug controls the cancer and what side ef…

This early-stage study tests a new drug called GSK5533524, alone or with other cancer treatments, in about 97 adults with advanced solid tumors that have stopped responding to standard therapies. The main goals are to find a safe dose and see if the drug can shrink tumors or slow…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This study offers female cancer patients aged 0-35 the chance to freeze a piece of their ovary before cancer treatment, then have it transplanted back later. The goal is to help them preserve their ability to have children. Researchers will monitor surgical safety and pregnancy r…

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can help some patients with stage II-IIIa bladder cancer avoid bladder removal. About 90 participants will receive either one or both drugs, and doctors will check if the cancer disa…

This early-stage study tests a new drug called GSK5764227, alone or with other cancer medicines, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors…

This study tests an experimental oral drug (GSK5460025) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H), which can make them harder to treat. The goal is to see if the drug can shrink tumors, how safe it is, and how the body processes it. …

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults whose tumor has returned after prior treatment will be randomly assigned to receive Avastin alone or …

This early-stage study tests a new drug called JNJ-87890387 in people with advanced solid tumors that have spread or cannot be removed. The main goal is to find a safe dose and check for side effects. About 200 adults with certain types of kidney, ovarian, uterine, colorectal, or…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer ce…

This early-phase trial tests a new oral drug, Aza-TdC, in adults with advanced solid tumors that have not responded to standard treatments. The drug aims to reactivate genes that may slow tumor growth. The main goals are to find a safe dose and check for side effects.

This study tests a new way to deliver a standard brain cancer drug (bevacizumab) using focused ultrasound and microbubbles in 10 people whose glioblastoma has returned. The goal is to see if this combination is safe and can help control tumor growth for longer. Participants must …

This early-stage trial tests a specially engineered virus, G207, in children and young adults (ages 3 to 21) whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is …

This study tests a new drug called AST-201 in people with advanced solid tumors that have a protein called GPC3. The main goal is to check the drug's safety and find the right dose. About 70 adults with liver or lung cancer that has not responded to other treatments will take par…

This early-phase study is testing a new treatment called JNJ-87704916, a virus designed to infect and destroy cancer cells. It is given as an injection directly into tumors, either alone or combined with another drug (cetrelimab). The study aims to find the safest dose and check …

This study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. It is given together with standard treatments to people with advanced solid tumors, such as colorectal or prostate cancer. The main goals…

This early-stage study tests a new treatment called IL-5 CAR-T for people with a rare and aggressive blood cancer called eosinophilic leukemia that has not responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and destroy ca…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. JV-394 uses a patient's own immune cells, modified to target and attack cancer cells. The main goal is to find the safest dose an…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults are being…

This study tests two drugs, nilotinib (a pill) and paclitaxel (given by IV), together in people with rare advanced cancers that have not responded to standard treatments. The goal is to see if the combination can shrink or stop tumor growth. About 82 adults with specific rare can…

This early-stage study tests a new drug (RO7673396) in people with advanced solid tumors that have RAS mutations and haven't responded to standard treatments. The study has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors when given alone or …

This early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the right dose, while also seeing if the drug can shrin…

This study looks at a way to help young women and girls with cancer keep their ability to have children. Doctors will freeze a piece of their ovary before cancer treatment starts. Later, after treatment, the tissue can be put back into the body. The goal is to see if this method …

This study aims to see if a new imaging agent called [18F]RCCB6 can improve PET/CT scans for diagnosing kidney cancer, especially the most common type (clear cell renal cell carcinoma). About 300 adults with confirmed or suspected kidney cancer will receive the agent and undergo …

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography) every two years to the usual yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women will take part. The goal is to improve det…

This study tests a new injection called [18F]LY4214835 to see if it is safe and how it spreads in the body. It includes both healthy volunteers and people with cancer. The goal is to improve cancer imaging, not to treat the disease. Participation lasts about 35 days.

This study looks at whether a special team of doctors, nurses, and other experts can help people aged 75 and older with digestive cancer complete their full course of chemotherapy or targeted therapy. The program starts early and focuses on managing side effects and overall well-…

This study tests a new program where nurses lead a team to help cancer patients be more physically active during their outpatient chemotherapy. 50 adult cancer patients will try the program, which includes activity plans, safety tips, and support materials. The goal is to see if …

This study tests whether a special massage technique (manual lymph drainage) can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. Researchers will enroll 40 people who completed radiation within the past year to see if a larger trial…

This study tests an experimental drug called LY3537021 to see if it can better control nausea and vomiting caused by chemotherapy. About 204 adults with cancer who are starting chemo will receive either the drug or a placebo. The main goal is to see if the drug helps prevent vomi…

This study tests a mobile health app designed to help cancer patients remember to take their oral medications and report symptoms. Researchers will enroll 35 English- or Spanish-speaking adults with cancer who are starting or recently started oral anticancer therapy. The goal is …

This study looks at new ways to screen for anal precancer in people at high risk, such as those with weakened immune systems. Researchers will test different screening methods to see which ones work best at finding precancerous cells. They will also study DNA and immune factors l…

This study monitors the long-term safety of people who have received ADP adoptive cell therapy for cancer. It will follow up to 250 participants for up to 15 years after their last treatment, checking for delayed side effects and viral DNA in the blood. The goal is to understand …

This study aims to create a computer-based tool that predicts which cancer patients are at risk of heart damage from certain chemotherapy drugs. Researchers will follow 600 patients in France for one year, collecting data to train a machine learning model. The goal is to help doc…

This study looks at 500 adults having cancer surgery to see which risk score best predicts if they'll need intensive care afterward. Doctors will compare several scoring tools to find the most accurate one. The goal is to help plan better care and use hospital resources wisely.

This study looks at how immunotherapy for advanced cancer changes a person's physical fitness and quality of life. About 67 adults with solid tumors will take fitness tests and answer questionnaires before starting treatment and again 12 weeks later. Researchers will also track l…

This study looks at proteins and other markers in the blood of 2,000 adults with or suspected of having cancer. The goal is to find markers that help confirm a diagnosis, choose the right therapy, and predict how well a patient will respond or if the cancer may return. Participan…

This study collects tissue and fluid samples (like blood, urine, and tumor tissue) from up to 5,000 children and adults with cancer at the NIH Clinical Center. The samples are used for research only, not for direct treatment. The goal is to help scientists learn more about cancer…

This study follows up to 5,000 people with Li-Fraumeni syndrome (LFS), a genetic condition that raises the risk for several cancers. Researchers collect medical and family history, blood samples, and questionnaires to better understand how TP53 gene changes and other factors affe…

This study is creating and testing an interactive online learning tool to help people with cancer improve their ability to find and understand health information online. 660 participants will be randomly assigned to use the tool, a PDF with the same information, or receive no int…

This study is creating a digital program to help East Asian immigrants who have cancer start conversations with their family about future medical care. The program is designed to be culturally sensitive and build emotional strength. Researchers will test how easy and acceptable t…

This study is creating a large collection of tumor samples and medical information from 1,500 people with pancreatic cancer. The goal is to provide resources for future research, not to test a new treatment. Participants will donate tissue and data during their standard care.

This study follows children and adults who have already received gene-modified T cells in a previous trial. Researchers will watch for long-term side effects, check how long the modified cells stay in the body, and monitor overall survival. No new treatment is given—this is a saf…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study is collecting health information from up to 40,000 people receiving radiation therapy for cancer. The goal is to learn what works best and how to reduce side effects. No new treatments are being tested—just tracking real-world results to improve future care.

This study looks at how a person's immune system might predict how well their cancer responds to radiation therapy. Researchers will collect blood samples from 40 adults who have already had radiation treatment without major side effects. The goal is to find immune markers that c…

This study looks at whether online health education workshops are practical and helpful for teenagers and young adults (ages 15-25) who have cancer. About 48 participants from across France will take part in three digital sessions designed to teach skills for managing daily life …

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a participant's past, current, and future studies. The goal is to better under…