NEOPLASMS

This study tests a combination of four drugs (irinotecan, dabrafenib, trametinib, and either cetuximab or panitumumab) as a second treatment option for people with advanced colorectal cancer that has spread and has a specific BRAF gene mutation. The goal is to see if this mix can…

This program gives adults with advanced or spreading ROS1-positive non-small cell lung cancer access to taletrectinib when they cannot use approved treatments or join ongoing studies. It is for patients who, in their doctor's opinion, might benefit from the drug. The goal is to p…

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study tests a new treatment for people with Hodgkin or non-Hodgkin lymphoma that has come back or not responded to other therapies. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells carrying a protein …

This early-phase study tests a new treatment for people with certain types of lymphoma that have not responded to standard therapy or have returned. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells, plus a…

This study aimed to test an experimental virus therapy, G207, given directly into the brain tumor along with a single dose of radiation for children whose high-grade glioma had come back after standard treatment. The goal was to see if this combination could help children live lo…

This study tests a new drug called E7386 combined with other anticancer drugs in people with advanced solid tumors, including endometrial, liver, and colorectal cancers. The goal is to find safe and effective doses and see if the combination can shrink tumors. About 300 participa…

This early-phase study tests a new experimental drug called GSK6097608, alone or with other cancer drugs, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. About 107 adults will take pa…

This study tests a new way to give the cancer drug amivantamab as a shot under the skin instead of through an IV. It includes 158 adults with advanced solid tumors that may respond to this type of treatment. The main goals are to check safety and find the best dose for the shot f…

This study tests a new oral drug (GSK4524101) alone and with another drug (niraparib) in adults with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 42 participants will …

This early-phase study tests a new experimental drug, BI 765179, in adults with advanced solid tumors or head and neck cancer. The first part finds the safest dose when given alone or with another drug (ezabenlimab). The second part checks if combining BI 765179 with pembrolizuma…

This study offers ongoing treatment with alectinib or crizotinib to people with ALK- or RET-positive cancer who were already benefiting from these drugs in a previous Roche study. About 200 participants will continue their medication while doctors monitor for side effects and saf…

This study offers continued access to the cancer drug atezolizumab for people who were already in a Roche-sponsored trial and still need treatment. About 49 participants will keep receiving their therapy while doctors monitor for serious side effects. The goal is to provide unint…

This early-phase study tests a new cell therapy called ACIT-1 in adults with pancreatic or other cancers. The goal is to find the safest dose that can boost the body's immune system to fight cancer. About 34 people will take part, and researchers will monitor side effects and sur…

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who have not had prior therapy. The goal is to me…

This study tests a treatment called Lete-Cel for people with advanced synovial sarcoma or myxoid/round cell liposarcoma that has not been treated yet. Lete-Cel uses the patient's own immune cells that are specially trained to attack cancer cells carrying a marker called NY-ESO-1.…

This study tests a treatment called Lete-Cel for people with advanced synovial sarcoma or myxoid/round cell liposarcoma that has not responded to prior therapy. Lete-Cel uses a patient's own immune cells that are specially engineered to recognize and attack cancer cells. The tria…

This study tests a special type of immune cell therapy for people with advanced solid tumors that have not responded to other treatments. The cells are taken from the patient, genetically modified to better recognize and attack cancer cells, and then given back. The goal is to se…

This study tests a new drug called TSR-022 in people with advanced solid tumors that have not responded to other treatments. The drug aims to help the immune system fight cancer by blocking a protein called TIM-3. The trial has two parts: first, finding a safe dose, and second, t…

This study tests an experimental drug called JNJ-63723283, which helps the immune system fight cancer. It is for people with advanced cancers like lung, melanoma, bladder, and others that have not responded to standard treatments. The goal is to find the best dose and see if the …

This study gives people with myelofibrosis continued access to the drug momelotinib after they finish a previous trial. The goal is to monitor long-term safety and see how long patients live. About 237 adults who are already taking momelotinib without their disease getting worse …

This study tests if bevacizumab, a drug that blocks blood vessel growth, can help adults with recurrent respiratory papillomatosis (RRP) go longer between surgeries. RRP causes wart-like growths in the airways that often return after removal. About 21 participants will receive th…

This early-stage study tests a new drug called remzistotug in 152 adults with advanced solid tumors that have stopped responding to standard treatments. The goal is to check the drug's safety and how the body processes it, both alone and with other cancer drugs. Participants must…

This study is testing an experimental drug called dostarlimab (TSR-042) in people with advanced solid tumors who have run out of standard treatment options. The drug works by helping the immune system attack cancer cells. The study has two parts: first, finding the safest dose, a…

This study tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy helps people with advanced or recurrent endometrial cancer live longer without their cancer growing. About 785 participants will receive either dostarlimab plus chemo or a placebo plus che…

This early-phase study tests a new experimental drug called GSK3745417, given alone or with another drug (dostarlimab), in about 97 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find a safe dose and check for side effec…

This study looks at whether contrast-enhanced mammography (CEM) can find breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women aged 30-85 will get both types of mammograms to compare detection rates and false alarms…

This study tests a 7-week group program led by trained peers (not doctors) to help cancer survivors reduce anxiety and depression after finishing curative treatment. 234 adults in Denmark who completed cancer treatment within the past year and have mild to severe symptoms are tak…

This study tests whether a culturally adapted strength training program, done together with a caregiver, is feasible and beneficial for Hispanic prostate cancer survivors and their caregivers. The program involves remote group exercise classes over 3 months, with a 3-month follow…

This study looks at how well the Ion Endoluminal System works in everyday medical practice for taking tissue samples from lung spots or nodules. About 1,300 adults who need a lung biopsy or lesion localization will be observed. The goal is to see how often the system correctly di…

This study enrolls 120 people with different cancers who already received treatment in an earlier study. The goal is to track serious side effects and other health issues over time. No new treatment is given; participants are simply monitored for safety.

This study looks back at the medical records of 232 adults with cancer who took the immunotherapy drug M7824. The goal is to create a complete list of all side effects caused by the drug. By understanding these side effects better, doctors hope to prevent or reduce them in future…

This study looks at whether educating doctors in small and mid-sized city hospitals about standard guidelines helps improve testing and treatment for people with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more get the right molecular tests…

This study tests a new technology that adjusts the radiation beam to follow lung tumors as they move when a person breathes during treatment. About 20 adults with early-stage lung cancer or limited lung metastases will take part. The goal is to see if the system works reliably an…

This study tests whether a modified clinical program can improve how doctors assess and prevent blood clots (venous thromboembolism) in cancer patients receiving treatment. About 25 clinicians and their patients will take part. The program includes education for doctors and requi…

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with possible cancer symptoms will take part. Half of the communities get the pro…

This study follows 400 children with growth hormone deficiency who are already taking somapacitan (a once-weekly injection) to see how safe it is over the long term. Researchers will track side effects, medication errors, and whether any children develop new health issues like di…

This study provides standard cancer care to up to 10,000 patients at the National Cancer Institute. It collects medical information from participants to help researchers better understand cancer and improve future treatments. Participants receive routine treatments, not experimen…

This study reviews existing medical records from Europe to understand how blood clots are treated in people with active cancer or a history of cancer. Researchers will look at which blood thinners are used, how often clots come back, and the costs involved. No new treatments are …