NEOPLASMS

This early-phase study tested a new drug called JNJ-70218902 in 82 people with advanced solid tumors, including prostate cancer. The goal was to find a safe dose and check for side effects. The drug works by redirecting the body's T cells to attack cancer cells, but it is not a c…

This study tested a new radioactive drug, 177Lu-NeoB, in 35 adults with advanced solid tumors that have a specific protein (GRPR). The goal was to see if the drug is safe, how it spreads in the body, and whether it can shrink tumors. Participants received the drug and were monito…

This small pilot study tested whether adding a focused ultrasound device (NaviFUS) to standard chemotherapy (bevacizumab) could help control recurrent glioblastoma, an aggressive brain cancer. Six adults whose cancer returned after prior treatment took part. The main goals were t…

This early-phase study tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see how the drug affects the body. TdCyd is taken by mouth in 3-week cycles, and researchers moni…

This early-phase trial tested two experimental drugs taken by mouth—FdCyd and THU—in 59 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see if the combination could control tumor growth. Participants took …

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma and solid tumors. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps cancer cells grow.

This early-phase study tested a new drug (BI 836880) alone or combined with another drug (BI 754091) in 21 Japanese adults with advanced solid tumors. The main goal was to find the safest dose and check for side effects. The study is complete, and results help guide future resear…

This study tested two experimental drugs, BI 754111 and BI 754091, that help the immune system attack cancer. It included 172 adults with advanced solid tumors, including non-small cell lung cancer that had returned after prior treatment. The first part found a safe dose; the sec…

This study looked at the long-term safety of an oral chemotherapy drug (azacitidine) in people with blood cancers. It enrolled 5 patients who had already taken the drug in earlier studies and were still benefiting from it. The main goal was to track any side effects that occurred…

This early-phase study tested the safety of combining multiple cancer drugs (niraparib, TSR-022, bevacizumab, chemotherapy, and TSR-042) in 60 adults with advanced or metastatic solid tumors, including lung cancer. The goal was to find safe doses for future larger studies. The tr…

This study tested a new cancer pill called brigimadlin in 266 adults with advanced solid tumors that had spread or stopped responding to standard treatments. The goal was to find the safest dose and see if the drug could shrink tumors. Participants took the pill either once every…

This early-phase study tested a new drug called MK-4464, given alone or with another drug (pembrolizumab), in 64 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety, how the drug moves through the body, and to find …

This early-phase trial tested a new drug called BI 836880 in 24 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose and check for side effects. Participants received the drug once a week through an IV. Th…

This early-phase study tested an experimental drug called MK-4830, either alone or combined with other cancer therapies like pembrolizumab, in 470 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the r…

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goals were to find a safe dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 week…

This early-phase trial tested a new drug called BI 754091 in 110 adults with advanced solid tumours that could not be removed by surgery or had spread. The main goals were to find the safest dose and check for side effects. Researchers also looked for signs that the drug might sh…

This early-phase study tested a new drug called LY3039478 in 247 adults with advanced or metastatic cancer, including lymphoma. The main goals were to find a safe dose and to see how the drug affects the body and tumors. While the study looked for signs of tumor shrinkage, it pri…

This study tested a combination of two experimental drugs—BI 836880 (blocks blood supply to tumors) and ezabenlimab (helps the immune system attack cancer)—in adults with advanced non-small cell lung cancer and other solid tumors. The goal was to find a safe dose and see if the c…

This early-phase study tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. The main goal was to find a safe dose and see how well…

This early-stage trial tested a new drug called BI 836880 in 29 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose and check for side effects. The drug was given through an IV, and researchers monitored …

This early-phase study tested a new drug called MRX-2843 in 42 adults with advanced or metastatic solid tumors that had not responded to prior treatments. The main goal was to check the drug's safety and find the best dose. Researchers monitored side effects and how the drug move…

This early-phase study tested a new drug called vibostolimab, either alone or combined with pembrolizumab (and sometimes chemotherapy), in 474 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the right…

This early-phase study tested two experimental drugs (BI 754091 and BI 754111) alone or together in 146 Asian patients with advanced solid tumours. The goal was to find safe doses and check for early signs of tumour shrinkage. The study is complete, but results are not yet public…

This study tested a new pill called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. The goal was to see if it could shrink enlarged spleens and reduce the need for blood transfusions. The drug was given alone or with another medicine (ruxoli…

This early-phase study tested a new treatment called RD13-02, which uses a patient's own immune cells modified to attack cancer cells with a specific marker (CD7). It involved just 2 people with blood cancers like T-cell acute lymphoblastic leukemia that had come back or not resp…

This study tested a new device called PointCheck that uses light to check for dangerously low white blood cell levels (neutropenia) in cancer patients without needing a needle. The study included 81 adults with blood or breast cancers who were getting chemotherapy. The main goal …

This study tested whether two advanced imaging techniques—high-resolution MRI and a special PET-MRI scan—can find prostate cancers that standard MRI might miss. 62 men who were considering focal HIFU therapy or prostate removal took part. The goal was to see if these newer scans …

This study tested a special pad (PadKit™) worn for 4-6 hours to collect cells shed from the uterus. Researchers checked if the pad could tell the difference between normal cells and cancer or precancerous cells. 80 women scheduled for surgery took part. The goal was to see if thi…

This study tested whether a mobile app helps cancer patients notice and report side effects from chemotherapy or radiation therapy. 222 adults with cancer who owned an Android smartphone used the app to track their symptoms. The goal was to see if using the app improved how patie…

This study looked at whether an expressive helping program—where patients write or record their thoughts—is practical and helpful for Chinese-speaking cancer patients and survivors. Sixty adults with any cancer type took part. The goal was to see if the program was easy to follow…

This study tested a financial navigation program to help cancer patients in rural and non-rural North Carolina deal with the high costs of care. 258 adults with cancer and significant financial distress took part. The program aimed to reduce financial toxicity and improve quality…

This study looked at whether a mix of in-person and online physiotherapy sessions is practical for children aged 4 to 17 with acute lymphoblastic leukemia. Ten children and their parents tried the program, which used an online platform for exercises and education. The goal was to…

This study looked at 33 adults who had both cancer and immune thrombocytopenia (ITP), a condition where the immune system destroys platelets. Researchers wanted to see if cancer cells and platelets share a protein that confuses the immune system. The main goal was to check if tre…

This study examined if the type of diabetes medication taken before a cancer diagnosis affects survival and complications after cancer in adults with obesity and type 2 diabetes. Researchers analyzed health records from over 200,000 people, comparing those who used GLP-1 receptor…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested a mobile program designed to help young adult cancer survivors (ages 18-39) eat healthier and exercise more. Researchers wanted to see if the program was easy to use and if participants liked it. The study involved 72 survivors and focused on whether people woul…

This study looked at 700 cancer patients to understand how often they develop dangerous blood clots (like deep vein thrombosis or pulmonary embolism). It focused on patients who already take blood thinners or have low platelet counts, which can complicate treatment. The goal was …

This study tested whether a computer could learn to recognize cancer pain by analyzing people's facial expressions and voices. 83 people with cancer recorded short videos at the clinic and at home over three months. The goal was to see if this technology could be a useful tool fo…