NEOPLASMS

This study aimed to see if a daily pill called pralsetinib works better than standard chemotherapy as the first treatment for people with advanced lung cancer that has spread and has a specific genetic change called a RET fusion. It involved 223 participants worldwide who had not…

This early-stage study tested the safety and initial effectiveness of a new drug called PF-07820435, both alone and combined with an existing immunotherapy (sasanlimab), in people with advanced solid tumors. The trial involved a small group of participants with cancers like lung …

This early-stage study aimed to find a safe and effective dose of a two-drug combination (niraparib and dostarlimab) for children and adolescents whose solid tumors returned or did not respond to standard treatments. It involved 47 young participants with cancers like osteosarcom…

This was an early-stage study to test the safety and find the right dose of a new cancer drug called PF-07826390. It was given alone or combined with another immunotherapy drug to people with advanced solid tumors that had spread or stopped responding to treatment. The main goal …

This early-phase study tested the safety and initial effectiveness of a new drug called modakafusp alfa, both alone and combined with an existing immunotherapy (pembrolizumab), in adults with advanced solid tumors or melanoma. The main goals were to find a safe dose and check for…

This early-stage study tested a new drug called OC-001, both by itself and combined with an existing immunotherapy drug, in people with various advanced cancers that had stopped responding to standard treatments. The main goal was to check the safety of the drug and see how the b…

This early-stage study tested a new targeted cancer drug called EO-3021 in adults with advanced stomach and other digestive cancers that had stopped responding to standard treatments. The main goal was to find a safe dose and see if the drug caused tumors to shrink. The study was…

This study tested two different drug combinations for people with advanced kidney cancer that had stopped responding to standard treatments. The trial aimed to find safe doses and see if these combinations could shrink tumors or slow disease progression. The study was terminated …

This study compared two ways to deliver radiation to ease pain from cancer that has spread to bones. It tested if a more complex, targeted technique caused fewer side effects like nausea than a simpler, faster method. The trial involved 160 adults with bone metastases and focused…

This early-stage study aimed to understand how moderate or severe liver problems affect the way a cancer drug (oral azacitidine) is processed in the body. It planned to compare adults with blood cancers and liver impairment to those with normal liver function. The main goal was t…