NEOPLASMS

This early-phase study tested a new drug (PF-07826390) alone or with another drug (sasanlimab) in 10 people with advanced solid tumors like lung, colon, or kidney cancer. The goal was to check safety and find the right dose. The study was terminated early, so results are limited.

This study tested a new drug called OC-001, either by itself or combined with avelumab (an immunotherapy), in people with advanced cancers that had spread. The goal was to check safety and how the drug moves through the body. The trial was stopped early, and only 73 people were e…

This early-stage study tested an experimental drug called EO-3021 in adults with advanced solid tumors, especially stomach cancer, that have a specific marker (CLDN18.2). The main goals were to check safety and find the right dose. The study was stopped early, so results are limi…

This study tested a new drug (NKT2152) combined with two other medicines (palbociclib and sasanlimab) in people with advanced clear cell kidney cancer that had worsened after prior treatments. The goal was to see if the combination was safe and could shrink tumors. The trial was …

This early-stage study tested a combination of two drugs, niraparib and dostarlimab, in children and teens (ages 6 months to 18 years) whose solid tumors had come back or did not respond to treatment. The main goals were to find a safe dose and see how the drugs worked in the bod…

This early-stage study tested a new drug, PF-07820435, alone or with another drug (sasanlimab), in 9 people with advanced solid tumors like lung, skin, and kidney cancers. The main goal was to check safety and find the right dose. The study was stopped early, so results are limit…

This study tested a new targeted pill, pralsetinib, against standard chemotherapy for people with a specific type of advanced lung cancer (RET fusion-positive) who had not yet received treatment. The goal was to see if the targeted drug could delay cancer growth better than chemo…

This study tested a new drug called modakafusp alfa, given alone or with another drug (pembrolizumab), in adults with advanced solid tumors or melanoma that had spread. The goal was to find safe doses and check for side effects. The trial was stopped early, but it aimed to see if…

This study compared two ways of giving radiation to people with cancer that spread to their bones. The goal was to see which method better controls nausea and vomiting caused by treatment, while also managing pain. About 160 adults took part, receiving either standard simple radi…

This study aimed to understand how moderate or severe liver impairment changes the way the body processes the cancer drug CC-486 (Onureg) in adults with certain blood cancers. Researchers planned to compare drug levels and safety between people with and without liver problems. On…