New hope for Hard-to-Treat cancers: experimental drug combo enters human trials
NCT ID NCT03843359
First seen Jan 10, 2026 · Last updated Jun 13, 2026 · Updated 30 times
Summary
This early-stage study tests a new drug called GSK3745417, given alone or with another drug (dostarlimab), in about 97 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find a safe dose and check for side effects. This is a first-in-human trial, so the drug's effectiveness is not yet known.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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GSK Investigational Site
Houston, Texas, 77030, United States
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GSK Investigational Site
Melbourne, Victoria, 3000, Australia
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GSK Investigational Site
Toronto, Ontario, M5G 1Z9, Canada
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GSK Investigational Site
Bordeaux, 33076, France
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GSK Investigational Site
Villejuif, 94805, France
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GSK Investigational Site
Tokyo, 104-0045, Japan
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GSK Investigational Site
Tokyo, 135-8550, Japan
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GSK Investigational Site
Amsterdam, 1066 CX, Netherlands
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GSK Investigational Site
Amsterdam, 1081 HV, Netherlands
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GSK Investigational Site
Seoul, 03080, South Korea
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GSK Investigational Site
Barcelona, 08035, Spain
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GSK Investigational Site
Madrid, 28040, Spain
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GSK Investigational Site
Madrid, 28050, Spain
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.