COVID19

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to see if the vaccine is safe and to measure the immune response it produces. Participants received two doses, with or without an immune booster (adju…

This study tested whether three common, inexpensive drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness in 1,323 adults with early COVID-19. Participants were not hospitalized and had a higher body weight, which increases risk. The key finding was that metfo…

This study tested a herbal supplement called AntiCov-220 in 82 adults with high-risk conditions like HIV or cancer. The goal was to see if it could safely prevent or treat COVID-19 by boosting the immune system and fighting the virus. The results focused on safety, with a few cas…

This study looked at whether giving a blood thinner (heparin) as a mist through a breathing tube could help COVID-19 patients who need a ventilator. 57 adults in intensive care units across several countries received either the heparin mist or standard care for up to 10 days. The…

This study tested whether giving hospitalized COVID-19 patients two doses of plasma from recovered people (convalescent plasma) helps them recover faster compared to standard care alone. 55 adults with pneumonia or low oxygen levels took part. The goal was to see if this treatmen…

This study tested a treatment called therapeutic plasma exchange (TPE) for people with severe COVID-19. TPE filters the blood to remove harmful inflammatory proteins that can cause breathing failure. The study compared 21 adults who got TPE plus usual intensive care to those who …

This early-phase study tested whether common mouthwashes can reduce the amount of SARS-CoV-2 virus that people with COVID-19 breathe out. 34 adults with a recent positive test provided breath samples using a face mask before and after rinsing with mouthwash or water. The goal was…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe, such as needing a breathing machine. Participants received the drug for 1…

This study tested a 6-week program called Heart Up! that uses text messages and support from nurses and loved ones to help adults with heart disease become more active and feel less hopeless. About 224 people who had a heart attack or related procedure took part. The goal was to …

This study tested whether common medications, originally made for other conditions, can reduce mild to moderate COVID-19 symptoms in adults aged 30 and older. Over 10,000 participants took either a study drug or a placebo at home and reported their symptoms remotely. The goal was…

This study tested whether a 30-week walking program is safe for cancer patients who have recovered from COVID-19. Three adults who had been hospitalized for COVID-19 and treated for cancer in the past took part. The goal was to see if the exercise caused few or mild side effects.

This study tested whether common medications already approved for other conditions could help people with mild to moderate COVID-19 feel better faster. Over 3,200 adults aged 30 and older with a positive COVID-19 test and at least two symptoms took either a study drug or a placeb…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers measured changes in their walking, memory, attention, and emotions as they moved from the hospital back home. They also compared these patients to healthy volunteers …

This study looked at how people with multiple sclerosis (MS) reported and managed relapses during the first wave of the COVID-19 pandemic (April–June 2020) compared to the same months in 2019. Researchers reviewed records from 51 patients across 5 UK hospitals to see if the pande…

This study followed 187 people who had COVID-19 to see how their antibody levels changed over two years. Researchers measured both general and neutralizing antibodies in the blood and nose, and also looked at how vaccination affected them. The goal was to learn how long protectio…

This study tested whether adding a quick TB test (Xpert Ultra) to standard care helps find tuberculosis earlier in young children hospitalized with severe pneumonia. Over 2,500 children in six high-TB countries took part. The goal was to see if early detection and treatment reduc…

This study looked at how different treatments and natural supplements affect the immune system of people with COVID-19. It included 150 patients who had symptoms like fever and lung inflammation. The goal was to see which approach helped the body fight the virus faster and reduce…

This study looked at how having COVID-19 or feeling stressed during pregnancy might affect a baby's brain development. Researchers followed 62 mothers and their infants, measuring stress, mental health, and baby brain activity. The goal is to better understand and support familie…

This study looked at how working in intensive care during the COVID-19 outbreak affected the mental health of doctors, nurses, and other caregivers. Over 700 healthcare workers answered questionnaires about post-traumatic stress disorder (PTSD), anxiety, depression, and burnout. …

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities in St. Louis. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. Over 1,300 students and staff took p…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (doctors, pharmacists, dentists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Results help guide p…

This study looked at how to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers to keep schools safe. Over 1,100 participants from special schools in Missouri and Maryland took part. Researchers tested different messages and…

This study followed 200 adults who had COVID-19 to see how the virus affects their heart and mental health over time. Participants wore a health tracker to monitor heart problems like irregular beats or heart failure, and answered surveys about anxiety, depression, and substance …

This study followed 105 pregnant women diagnosed with COVID-19 to learn how their immune systems responded and whether that protection passed to their babies. Researchers measured antibodies in mothers and newborns, as well as in breast milk, up to 6 weeks after birth. The goal w…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers tested 450 people for the virus using nose swabs and also checked for antibodies to see who had been infected before. The goal was to understand infection…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their ability to move and do daily activities changed over time. Researchers measured mobility, thinking skills, and frailty both in the hospital and after discharge. The goal is to understand rec…

This study looked at 543 people who survived severe COVID-19 lung injury (ARDS) to see if their income, job, or social support affected their recovery. Researchers measured breathing problems, mental health, and quality of life six months after leaving the hospital. The goal is t…

This study used advanced total-body PET scans to see how COVID-19 affects the lungs' blood-air barrier. Researchers compared 13 adults who had COVID-19 with healthy volunteers, and then followed up with the COVID-19 group four months later. The goal was to understand long-term lu…

This study looked at 355 adults with Long COVID in Suffolk and North Essex to understand their symptoms and rehabilitation needs up to 3 years after infection. Researchers focused on how the condition affects daily life and the ability to return to normal activities. The goal is …

This study followed 113 people with cystic fibrosis (CF) over two years to see how many had antibodies from COVID-19 infection or vaccination. Researchers collected blood samples and health data to understand if CF patients are less likely to get COVID-19 and how their immune sys…

This study followed 300 adults who had mild to moderate COVID-19 but were not hospitalized. Researchers called them monthly for a year to see how long symptoms lasted and how they affected daily activities. The goal was to understand the course of lingering symptoms after a mild …

This completed Phase 2 trial aimed to test a master protocol that could be used to evaluate the safety and effectiveness of different drug combinations for COVID-19 patients. The study planned to enroll both hospitalized and non-hospitalized adults, but only 4 people took part. T…

This study looked at 85 hospitalized patients to understand how the thymus—the organ that produces T cells—affects COVID-19 outcomes. Researchers examined genetic markers and CT scans to see if thymus activity influences pneumonia severity. The goal was to learn why some people g…

This study tested whether analyzing the chemicals in a person's breath could help diagnose or predict liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants and looked for specific patterns of volatile organic compounds. The goal was …

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very sick patients. …

This study looked at how the COVID-19 pandemic affected online gambling in France and Sweden. Researchers analyzed data from 120,000 gamblers to see if lockdowns and stress led to more gambling. The goal was to understand changes in gambling habits and identify groups at risk for…

This study looked at 50 people who were hospitalized for COVID-19 to understand why they often feel tired and have trouble breathing after recovery. Researchers measured the strength of breathing muscles in two groups: those who needed a breathing machine and those who only neede…

This study looked at eye problems in 23 COVID-19 patients in intensive care. Researchers checked for damage to the cornea, retina, and optic nerve to find and treat issues early. The goal was to prevent permanent vision loss in these very sick patients.