COVID19

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The vaccine uses a virus-like particle to train the immune system, and some doses included an adjuvant to boost response. The main goals were to check safety and m…

This Phase 2 trial tested whether combining famotidine (Pepcid) and celecoxib (Celebrex) could help people with COVID-19 recover faster. Only 4 participants were enrolled, making it too small to draw firm conclusions. The study aimed to see if these drugs could reduce symptom sev…

This study tested a herbal supplement called AntiCov-220 in 82 adults with high-risk conditions like HIV or cancer. The goal was to see if it could prevent COVID-19 infection and reduce symptoms. The supplement contains a mix of herbs and vitamins thought to boost the immune syst…

This study tested whether giving plasma from people who recovered from COVID-19 to those with severe or critical COVID-19 is safe and helps them get better. 350 adults received the plasma treatment. The main goals were to track serious side effects and see if fewer people died wi…

This early study tested whether over-the-counter mouthwash could lower the amount of SARS-CoV-2 virus people breathe out. 34 adults with recent COVID-19 used mouthwash or water, and researchers measured virus in their breath and saliva before and after rinsing. The goal was to se…

This trial tested whether inhaling heparin, a common blood thinner, could help COVID-19 patients who need a breathing machine (ventilator) recover faster. Researchers combined data from several small studies in Australia, Ireland, the US, and the UK involving 57 patients. The goa…

This phase 3 trial tested whether the drug aviptadil can help hospitalized COVID-19 patients with acute respiratory distress syndrome (ARDS). 471 participants received either aviptadil plus standard care or a placebo plus standard care. The main goal was to see how well patients …

This study tested the antiviral drug remdesivir in 87 hospitalized COVID-19 patients with acute respiratory distress syndrome (severe breathing failure). Participants received either remdesivir plus standard care or a placebo plus standard care for 10 days. The main goal was to s…

This study looked at whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help critically ill patients fight the virus. The plan was to collect plasma from up to 240 recovered donors and give it to sick patients. However, the plasma donat…

This study tested two drugs, ruxolitinib and fostamatinib, in 185 hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe, such as needing a ventilator or dying. Patients took the drug for 14 …

This study tested whether certain drugs could help hospitalized COVID-19 patients with severe breathing problems. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if the drugs improved safety and recovery.

This study tested a blood-filtering procedure called plasma exchange in 21 adults with severe COVID-19 and breathing problems. The goal was to remove harmful inflammatory substances from the blood to improve lung function and reduce the need for a breathing tube. Patients receive…

This study tested a new way of using breathing machines for COVID-19 patients with severe lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. About 220 adults on ventil…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This study looked at whether giving hospitalized COVID-19 patients two doses of plasma from people who had recovered from COVID-19, on top of standard care, helps them recover faster. 55 adults with pneumonia or low oxygen levels took part. The main goal was to see if this treatm…

This study tested a quick COVID-19 antigen test called LumiraDx at various point-of-care sites, like clinics. Over 1,100 people with COVID-19 symptoms took part. The test's accuracy was compared to standard lab methods to see how well it detects the virus.

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This study tested whether using box fans with special filters and improving home ventilation could lower the chance of COVID-19 spreading from one infected person to others living in the same home. Researchers studied 214 people living in households with at least 3 members. The g…

This study tested two practical methods to increase COVID-19 vaccination among over 65,000 patients at Utah community health centers. One group received text message reminders to get vaccinated, while another group got texts plus a personal navigator to help with logistics like s…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This large study tested whether common medications like ivermectin and fluvoxamine can help ease mild-to-moderate COVID-19 symptoms in adults who are not hospitalized. Over 10,000 participants took either the study drug or a placebo and reported their symptoms remotely. The goal …

This study tested a 30-week walking program for cancer survivors who had been hospitalized with COVID-19. The goal was to see if the exercise was safe and caused few side effects. Only 3 people took part, so the results are very early and not conclusive.

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested whether common medications, originally made for other illnesses, could help adults aged 30 and older recover faster from mild to moderate COVID-19 without needing hospital care. Over 3,200 participants took either a study drug or a placebo and reported their sym…

This study tested a 21-herb formula called modified Qing Fei Pai Du Tang (mQFPD) in 60 adults with mild-to-moderate COVID-19 who were recovering at home. The goal was to see if the herbal treatment is safe and practical to use. Participants received either the herbal formula or a…

This study tested a 6-week program called Heart Up! that uses text messages and social support to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The program aimed to im…

This study looked at whether playing motion-controlled video games in virtual reality can help people with long COVID feel less pain and fatigue, improve their mood, and boost their quality of life. About 79 adults who had COVID-19 more than 90 days ago and still had symptoms for…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who had severe COVID-19 recover faster. 22 patients who needed a breathing machine were split into two groups: one did cycling with FES, the other without. The goal was to s…

This study looked at eye problems in 23 COVID-19 patients in intensive care. Doctors checked for damage to the cornea, retina, and optic nerve at several time points. The goal was to find and treat eye issues early to prevent vision loss.

This study monitored 219 adults with severe COVID-19 who needed a ventilator to see how many developed serious fungal infections, especially from Aspergillus. Researchers used standard diagnostic tests to check for these infections regularly. The goal was to learn how common thes…

This completed study followed 105 pregnant women who had COVID-19 or received a COVID-19 vaccine. Researchers measured antibodies in the mothers' blood and breast milk, as well as in the umbilical cord blood at delivery, to see how immunity transfers to the baby. The goal was to …

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study used advanced total-body PET scans to look at how COVID-19 affects the lungs' blood-air barrier in 13 people. Researchers compared COVID-19 patients to healthy subjects and tracked changes over 4 months. The goal was to understand lung damage, not to test a treatment.

This study followed 211 older adults who were hospitalized with COVID-19 to see how their mobility and daily function changed over time. Researchers measured physical abilities like walking, balance, and thinking skills. The goal is to understand recovery patterns so doctors can …

This study followed 1,366 people in Luxembourg who tested positive for COVID-19. Researchers tracked their symptoms and health for up to a year to understand why some get very sick while others have mild illness. The goal was to find factors that predict severe disease, not to te…

This study examined whether strict COVID-19 rules in nursing homes (like banning visitors and confining residents) saved lives or caused harm. Researchers tracked over 12,000 residents for one year, comparing death rates in homes that followed guidelines closely versus those that…

This study followed 214 people who tested positive for COVID-19. Participants received daily text messages asking about their symptoms, like fever, cough, and loss of taste or smell. The goal was to learn how symptoms develop and vary throughout the day, helping researchers bette…

This study looked at how different treatments affect the immune system in people with COVID-19. It included 150 adults with mild to moderate symptoms, such as fever and lung inflammation. The goal was to see which treatments help the body fight the virus and speed up recovery.

This study examined how people with mild or no COVID-19 symptoms respond to the virus. Researchers measured immune markers in the blood of 57 adults who tested positive. The goal was to understand why some people clear the virus quickly while others develop severe illness.

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…

This study examined how the COVID-19 pandemic affected online gambling behaviors in France and Sweden, two countries with different lockdown approaches. Researchers analyzed data from 120,000 gamblers to track changes in gambling activity and use of responsible gambling tools. Th…

This study collected nose and throat swabs from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a rapid point-of-care test. The goal was to see how well the device detects these viruses in different people.

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study followed 300 adults who had mild to moderate COVID-19 and were not hospitalized. Researchers called them monthly for a year to see how long symptoms lasted and how they affected daily activities. The goal was to understand the course of the disease and describe lingeri…

This completed study looked at whether people with cystic fibrosis (CF) have different COVID-19 antibody responses compared to the general population. Researchers followed 113 adults and children with CF across Europe for two years, testing their blood for SARS-CoV-2 antibodies a…

This completed study enrolled over 1,000 people in the Dominican Republic to track how COVID-19 spreads and how to control it. Researchers provided some households with alcohol-based hand sanitizer and monitored handwashing habits, virus exposure, and vaccine attitudes. The goal …

This completed study looked at whether the COVID-19 vaccine triggers a strong immune response in 146 people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose. The goal was to see if these patients, …

This completed study looked at breathing muscle strength in 50 people who were hospitalized for COVID-19. Half had been on a ventilator, and half needed only extra oxygen. Researchers used advanced tests, including nerve stimulation and ultrasound, to measure diaphragm function. …

This study looked back at the medical records of 11,000 COVID-19 patients to find out how often they developed dangerous blood clots in arteries or veins. Researchers also wanted to identify who was most at risk and how these clots were managed. The goal was to better understand …

This study examined eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used advanced eye imaging to look for problems like inflammation, blood clots, and nerve damage. The goal was to better understand how COVID-19 can harm vision.

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study looked at why lying face down (prone positioning) improves breathing in patients with acute respiratory distress syndrome (ARDS), including those with COVID-19. Researchers used lung ultrasound to measure lung health in 60 adults on ventilators. The goal was to underst…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or lupus). Researchers measured stress, depression, and anxiety levels over 6 months. The goal was to unde…

This study looked at how a mix of home and in-person exercise sessions affects the body in people with chronic lung diseases like COPD and sleep apnea, as well as those recovering from COVID-19. The goal was to see if this program helps with muscle loss and fatigue. 72 adults age…

This study looked at the mental health of 701 healthcare workers (doctors, nurses, and aides) who cared for COVID-19 patients in intensive care units. Researchers measured rates of post-traumatic stress disorder (PTSD), anxiety, depression, and burnout using standard questionnair…

This study measured immune responses after two doses of the Pfizer COVID-19 vaccine in 539 adults, including those with weakened immune systems (e.g., from organ transplant, HIV, or cancer treatment) and healthy individuals. Researchers analyzed blood and saliva samples to see ho…

This study looked at how the thymus gland, which produces immune cells called T cells, might influence COVID-19 severity. Researchers compared 85 hospitalized patients with and without COVID-19 to see if genetic differences in thymus function were linked to worse lung damage. The…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies from infection or vaccination. Researchers followed 152 adults and children with CF for two years, taking blood samples every six months. They aimed to understand how many had antibodies, how l…

This study followed 187 people who had COVID-19 to see how their antibody levels changed over 24 months. Researchers measured both general and neutralizing antibodies, and also looked at how disease severity and vaccination affected these levels. The goal was to better understand…

This study followed 610 adults who had heart surgery to see how often they develop postoperative delirium—a sudden state of confusion that can come and go. Researchers collected information on known risk factors like age, high blood pressure, and diabetes, and tracked outcomes su…

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. The goal was to see which approach reduced COVID-…

This study followed 200 adults who had COVID-19 to see how the virus affects their heart and mental health over time. Participants wore a health tracker to monitor heart problems like irregular beats and heart failure, and completed surveys about anxiety, depression, and substanc…

This study followed 355 adults in Suffolk and North Essex who had Long COVID (symptoms lasting after a COVID-19 infection). The goal was to describe their symptoms and rehabilitation needs up to 36 months after getting sick. Researchers focused on how the condition affected daily…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers tracked their thinking, movement, and emotional health as they moved from hospital to home. The goal was to better understand the challenges these patients face durin…

This study aimed to develop a breath test that could help diagnose or predict the course of liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants to detect unique chemical patterns. The goal was to see if a simple, non-invasive breat…

This completed study looked at 543 people who survived severe COVID-19 lung injury (ARDS) to see if their social and economic background influenced how well they recovered physically and mentally. Researchers measured lung function, exercise ability, and psychological health six …

This study followed 829 adults who had COVID-19 to see how long their immune system remembered the virus. Researchers measured antibodies in blood samples taken during the hospital stay and for up to 12 months after. The goal was to understand how long natural immunity might last…

This study looked at whether weakness in the diaphragm, the main breathing muscle, causes ongoing shortness of breath and fatigue in people who had COVID-19 but were not hospitalized. Researchers measured breathing muscle strength and used ultrasound in 25 adults. The goal was to…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Results hel…

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This study looked at how a COVID-19 infection during pregnancy, along with related stress, might affect a baby's brain development. Researchers followed 62 mothers and their infants, using surveys to measure stress and mental health, and brain scans (EEG and MRI) to check the bab…

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—caused worry or raised the risk of lymphedema (arm swelling) in these patients. The study collected…

This study investigated whether COVID-19 infection makes people more likely to develop pulmonary embolism (PE), a serious blood clot in the lungs. Researchers reviewed CT scans and COVID-19 test results from 347 patients in Scotland. The goal was to confirm and measure this link …

This study compared two methods to increase COVID-19 testing among patients at Utah community health centers: text message reminders alone versus text messages plus a patient navigator who helped with logistics. Over 44,000 English- or Spanish-speaking adults with a working cell …

This study used a special type of MRI (called hyperpolarized 129Xe MRI) to look at lung structure and function in 42 adults who had recovered from mild, moderate, or severe COVID-19. The goal was to understand how the virus affects breathing over time. Participants were scanned a…

This study looked at 332 adults who had severe COVID-19 pneumonia and needed oxygen in the hospital. Researchers used CT scans and breathing tests to check for lasting lung damage three months after discharge. The goal was to understand how often and how severe these respiratory …