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Mouthwash vs. COVID: small study tests if a rinse cuts virus in breath

NCT ID NCT04931004

Disease control Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tested whether over-the-counter mouthwash could lower the amount of SARS-CoV-2 virus people breathe out. 34 adults with recent COVID-19 used mouthwash or water, and researchers measured virus in their breath and saliva before and after rinsing. The goal was to see if mouthwash might reduce how much virus spreads into the air, not to treat or prevent illness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mouthwash (cetylpyridinium chloride)
What this could lead to
If mouthwash temporarily lowers virus in breath, it might help reduce spread in close-contact settings.
What could go wrong
Very early, tiny study (34 people). Only measures short-term viral load in breath/saliva, not infection or transmission. Mouthwash cannot treat or prevent COVID-19.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

34 people

The number who actually took part.

Started

Jul 2021

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 2. Able to provide consent 3. Polymerase chain reaction (PCR)-confirmed SARS-CoV-2 within previous 48 hours. Exclusion Criteria: 1. Clinical contraindication or poor feasibility to complete study procedures 2. Unwilling or unable to produce saliva or face mask samples 3. Unable to produce at least 500 microliters of saliva. 4. Eaten within past 30 minutes 5. Known allergy to mouthwash products

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19

Contacts and locations

Locations

  • University Hospital

    Newark, New Jersey, 07103, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.