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Could a different way of pedaling rebuild muscles after severe COVID-19?

NCT ID NCT04649086

Disease control Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study tests whether a specific type of exercise, called eccentric exercise, can help people recover muscle strength and walking ability after a severe COVID-19 infection. Participants, aged 18 to 80, will be randomly assigned to either eccentric or standard concentric exercise sessions on a stationary bike over two months. The main goal is to see if eccentric exercise leads to greater improvements in walking capacity, as measured by the six-minute walk test.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Eccentric exercise rehabilitation using a cycloergometer
What this could lead to
If eccentric exercise proves more effective, it could offer a faster, more efficient rehabilitation path for people recovering from severe COVID-19, potentially reducing care costs and duration.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. Eccentric exercise may be harder to tolerate or carry risks for some patients, and the benefits over standard exercise are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jun 2020

Finished

Jan 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female, 18 to 80 years old * Diagnosed for SARS-CoV-2 infection (COVID-19) requiring a rehabilitation program at least 1 month after the hospitalization * Autonomy in daily life activities 1 month after diagnosis * Able to walk for 6 min (discontinuous walking possible) * Giving informed written consent to participate in the study * Health insurance coverage Exclusion Criteria: * Cardiovascular or respiratory contraindication to the rehabilitation program * Difficulty to perform an eccentric exercise on a seated ergometer * Pregnant or breastfeeding * Under guardianship, curatorship or deprived of liberty * Taking antivitamin K anticoagulation (muscle biopsy) * Refusal to participate

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Conditions

The condition(s) this trial relates to.

COVID-19 Muscle Weakness Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19 Muscle weakness Sarcopenia

Contacts and locations

Locations

  • CHU de Clermont-Ferrand

    Clermont-Ferrand, 63000, France

  • CHU de Dijon

    Dijon, 21000, France

  • CHU de Saint-Etienne

    Saint-Etienne, 42000, France

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