Heartburn and arthritis drugs tested against COVID-19
NCT ID NCT05077332
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tested whether combining famotidine (Pepcid) and celecoxib (Celebrex) could help people with COVID-19 recover faster. Only 4 participants were enrolled, making it too small to draw firm conclusions. The study aimed to see if these drugs could reduce symptom severity and prevent hospital visits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Famotidine (Pepcid) and celecoxib (Celebrex)
- What this could lead to
- If it works, this could point toward a safe, over-the-counter drug combination to help manage COVID-19 symptoms at home.
- What could go wrong
- This was a very small, early-phase trial with only 4 participants, so results are not reliable. The drugs may not work against COVID-19, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
4 people
The number who actually took part.
- Started
-
Dec 2021
- Finished
-
Nov 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* For eligibility criteria specific to the protocol, see: * Addendum #1 (LDOS-21-001-01) or * Addendum #2 (LDOS-21-001-02)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
US02-04: Integrated Health Solutions
Miami, Florida, 33126, United States
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