CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study looked at how well the Trimbow inhaler works for people with COPD when used in real-world conditions, not just in a lab. Over 12 weeks, 362 adults aged 40 and older used the inhaler, which combines three medicines to open airways and reduce inflammation. The main goal …

This study looked at whether having a pharmacist talk with patients at home after a hospital stay could reduce flare-ups of chronic obstructive pulmonary disease (COPD). 174 adults with moderate to severe COPD took part. The main goal was to count how many times patients had wors…

This study tested three different doses of an inhaled medication called glycopyrrolate in 46 adults with COPD. Participants used the drug twice daily for one week to see if it improved their lung function compared to a placebo. The goal was to find out how well it works and if it…

This study tested a program in Xishui, China, that encouraged doctors to focus on the overall health of people at high risk for COPD. Over 9,300 adults aged 35 and older with a high COPD risk score took part. The program included lung tests, health education, and help managing ot…

This study tested whether a natural hormone called DHEA can help adults with COPD who also have high blood pressure in their lungs (pulmonary hypertension). 51 participants took either a low or high dose of DHEA daily for one year. The main goal was to see if DHEA improved how fa…

This study looked at whether adults with acute illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. 160 rural patients were randomly assigned to receive hospital-level care at home or usual hospital care. The goal was to see if…

This study looked at whether a mobile app can help people with COPD maintain the gains from a 4-week pulmonary rehab program. 200 patients used either the app or standard care for a year. The goal was to see if the app helped them stay active and have a better quality of life ove…

This study tested whether a new inhaler (CHF 1535) works as well as a standard one (Symbicort) for people with chronic obstructive pulmonary disease (COPD). About 750 Chinese adults aged 40 and older with moderate-to-severe COPD took part. The main goal was to compare changes in …

This study followed 200 adults with moderate to severe COPD who started taking the triple-combination inhaler BREZTRI as part of their normal care. Researchers measured changes in symptoms and breathing over 24 weeks using standard questionnaires and lung function tests. The goal…

This study looked at whether monitoring COPD patients' home ventilators from a distance can improve how well they use the machine and reduce hospital visits. 54 adults who needed a ventilator at home were split into two groups: one received standard in-person checkups every six m…

This study tested a drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants received either the drug or a placebo as an inj…

This study looked at whether adding a statin (a common cholesterol-lowering drug) to standard treatment can reduce airway inflammation and improve breathing in people with severe chronic obstructive pulmonary disease (COPD). Researchers measured blood markers of inflammation and …

This study tested an experimental drug called astegolimab in over 1,300 people with chronic obstructive pulmonary disease (COPD) who had frequent flare-ups. Participants received either the drug or a placebo alongside their usual COPD treatments. The main goal was to see if asteg…

This study tested a new inhaled drug combination (ensifentrine and glycopyrrolate) in 33 adults with COPD. The goal was to see how the drug moves through the body, how well it helps breathing, and if it is safe. Participants received single doses of the combination and each drug …

This study tested whether a triple-combination inhaler (BGF MDI) helps people with moderate to severe COPD breathe easier and exercise longer compared to a placebo or a dual-combination inhaler. 171 adults aged 40-80 participated. The main goal was to measure lung capacity and en…

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD, a serious lung disease often caused by smoking. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants were fo…

This early study tested whether a single infusion of mesenchymal stem cells is safe for people with advanced COPD. Fifteen participants received the treatment and were monitored for any immediate side effects. The goal was to see if the procedure could be tolerated without causin…

This study tested whether switching from a standard two-drug inhaler to a new three-drug inhaler (CHF5993) could improve lung function in 25 people with advanced COPD. Researchers used special imaging to measure airway volume and airflow. The goal was to see if the new inhaler wa…

This early-stage study tested a drug called EP395 in 49 healthy adults to see if it could reduce inflammation in the lungs. Participants inhaled a substance that causes temporary airway inflammation, and researchers measured whether EP395 lowered that response compared to a place…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked safety, immune respons…

This study tested whether an internet-based sleep treatment could improve sleep and quality of life in veterans with both COPD and insomnia. Thirteen veterans were randomly assigned to either an online behavioral sleep program or online sleep education. The goal was to see if bet…

This study looked at whether taking L-arginine and liposomal vitamin C supplements could help reduce fatigue in people with COPD and chronic respiratory failure after completing a pulmonary rehabilitation program. The study involved 101 participants aged 40 to 90. The goal was to…

This study looked at whether adding a digital remote monitoring system to a standard lung rehabilitation program is practical for people with COPD. 78 participants were split into two groups: one got the standard program, and the other also used a digital device to track their he…

This study tested whether a set of breathing exercises and devices (PowerBreathe and Therosold PEP) could improve lung function in 60 elderly patients with COPD. Participants were split into two groups to compare different training routines. Researchers used ultrasound and breath…

This study tested if giving a common COPD drug (salbutamol) through a special high-flow nasal device works as well as the usual mask method. 25 adults with COPD took part. The goal was to see if the nasal method could improve breathing just as much as the standard approach.

This study tested a gentle movement therapy called Basic Body Awareness Therapy (BBAT) as an add-on treatment for 25 people with COPD who struggle with breathlessness. BBAT focuses on balance, free breathing, and mental awareness to help patients better manage their symptoms. The…

This study looked at whether a combination inhaler (tiotropium/olodaterol) can improve exercise ability in people with COPD who have overinflated lungs. 44 adults with COPD used the inhaler for 4 weeks. Researchers measured changes in oxygen use during exercise, heart function, a…

This study looked at whether pursed lip breathing exercises and laughter therapy can reduce shortness of breath and improve daily life for people with COPD. 63 adults with COPD were split into three groups: one did breathing exercises, one did laughter therapy, and one received s…

This study looked at whether adding special breathing muscle training to a standard 3-week lung rehab program helps reduce shortness of breath in people with COPD. The trial included 38 patients with normal breathing strength. Researchers measured changes in how patients rated th…

This study tested the drug itepekimab in 49 adults aged 40 to 70 with COPD who were either former or current smokers. The goal was to see how the drug works on airway inflammation, not to cure or treat the disease. Participants stayed on their usual COPD medications during the 12…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer talk about their care wishes while in the emergency department. Researchers worked with 141 patients to see if the program increased how often they discussed the…

This study tested whether a virtual reality room (VR CAVE) could teach community nursing skills as effectively as a physical mock home. 150 final-year nursing students tried both methods. Results showed both approaches improved clinical skills equally, but students felt more sati…

This study followed 250 adults with COPD in Italy who started taking the triple-combination inhaler Trixeo (budesonide/glycopyrronium/formoterol). Researchers measured how patients felt about their health after 12 weeks and up to one year of treatment. The goal was to see real-wo…

This study looked at past patient records to see if a computer program could predict who would need to be readmitted to the hospital within 30 days of leaving. Researchers used data from 372 patients treated at home through a hospital program. The goal was to improve care, not to…

This study looked at how a short-term fiber supplement (inulin) changes gut bacteria and metabolism in people with COPD compared to healthy older and younger adults. Researchers measured fatty acid production and gut health markers from blood and stool samples. The goal was to un…

This study looked at whether a special mix of essential amino acids (with extra leucine) could help elderly people with COPD build protein better than a standard amino acid supplement. Thirty-four participants received both supplements on separate days, and researchers measured h…

This study looked at 178 people with advanced cancer, chronic kidney disease, or chronic lung disease to find out when they need palliative care. Researchers used special scores to see if care was given at the right time. No extra treatments or visits were added—just observation …

This study looked at whether a simple six-minute stepper test can give similar information as a more complex exercise test for people with COPD. The goal is to make it easier for patients to get the right exercise prescription for pulmonary rehabilitation. 65 adults with COPD par…

This study looked at whether a six-minute stepper test can measure changes in exercise ability in people with COPD after a 3-week pulmonary rehabilitation program. Researchers enrolled 72 patients with all stages of COPD. The goal was to see if the number of steps taken before an…

This study tested whether a telerehabilitation system can reliably send health data from people with COPD at home. 40 participants used devices like pulse oximeters and activity trackers during an 8-week home exercise program. The goal was to see if the data transmitted accuratel…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a blood clot in their lungs (pulmonary embolism). Doctors used a standard set of tests, including a blood test and a special CT scan, to check for clots. The goal was to learn how commo…

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were then treated with a medication called BGF. Researchers tracked how often patients had another flare-up or heart-related event over time. The goal was to learn more about real-wo…

This study looked at whether taking fish oil supplements (EPA and DHA) for four weeks could help people with COPD build more muscle when they eat protein. 64 adults with moderate to severe COPD took part. Researchers measured muscle protein building using special isotope methods …

This study analyzed health records from nearly 1 million Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers looked at changes in doctor visits, tests, and treatments before and du…

This study looked at how well people with severe COPD follow their prescribed long-term oxygen therapy. Researchers used a connected device called TeleOx and a smartwatch to track oxygen use and heart rate over 14-day periods. The goal was to give doctors better information betwe…

This study looked at how the body handles short-chain fatty acids (SCFAs) in people with COPD compared to healthy adults. Researchers measured SCFA metabolism and body composition in 63 participants. The goal was to understand if SCFA production is lower in COPD, which could affe…

This study looked at data from 526 patients treated at home through a hospital-at-home program. Researchers used a computer algorithm to try to predict if a patient would get worse during their stay. The goal was to see if machine learning could help doctors spot problems earlier…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or type 2 diabetes. 178 adults in Leicester, UK, used the app for 12 weeks and gave feedback on its usability. The goal was to see if the app is…

This study looked at whether people with COPD have more leakage in their lung blood vessels during exercise, which might cause shortness of breath. Researchers compared 32 participants (COPD patients and healthy controls) by measuring lung changes before and after exercise. The g…

This study looked at how people with COPD experience physical activity. Researchers interviewed 54 participants and used activity monitors to compare standard intensity measures with personalized ones. The goal was to better understand what physical activity means to patients and…

This study looked at whether three different inhaler testers (Accuhaler, Ellipta, and Turbutester) can accurately measure how hard COPD patients can breathe in. 82 adults with COPD used the testers, and the results were compared to a standard device. The goal was to see if these …

This study tested a special breathing-synchronized PET scan method to get clearer images of small lung nodules. 103 adults with lung nodules (from cancer or COPD) had a standard PET scan plus an extra 10-minute gated scan. The goal was to see if the new method reduces motion blur…

This study looked at how a breathing technique called ELTGOL affects air distribution in the lungs of people with COPD and healthy volunteers. Participants lay on their side while researchers applied gentle pressure to the chest and abdomen. The goal was to understand how these p…

This early-stage trial tested the safety of Hemay005 tablets in 468 healthy Chinese adults. Researchers compared different ways of giving the drug (gradually increasing the dose vs. fixed dose) to see which caused fewer side effects. The goal was to gather safety information befo…

This study looked at 100 people with advanced COPD to see if the presence of aspergillus fungus in their sputum is linked to worse quality of life and breathing problems. Participants provided sputum samples and filled out questionnaires at the start, then again by phone after 1 …

This study involved 100 patients with serious illnesses like cancer, heart failure, COPD, or ALS who were receiving palliative care. Researchers used a questionnaire to find out patients' spiritual needs and then provided specialized spiritual care to address them. The goal was t…

This study gathered information from 101 patients and healthcare providers to design a care pathway for COPD in people with lung or head and neck cancer. The goal was to reduce treatment burden and overcome common barriers to COPD care in community oncology clinics. Researchers u…