CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study is checking the long-term safety of a drug called tozorakimab in people with COPD who have had flare-ups in the past. About 82 adults who finished a previous tozorakimab study will take the drug and be monitored for side effects. The goal is to see if the drug remains …

This study follows 1,400 adults with moderate to severe COPD who are starting the triple-combination inhaler Breztri/Trixeo. Researchers will track changes in symptoms and quality of life over 12 months in routine clinics across Latin America, Asia, and the Middle East & Africa. …

This study tests whether using high-flow oxygen at home can reduce the number of severe COPD flare-ups or deaths compared to standard oxygen. About 406 people who have been hospitalized for a serious COPD attack will take part. The goal is to see if this approach keeps them healt…

This study follows 1,000 people aged 12 and older in China who have severe eosinophilic asthma and are prescribed benralizumab. Researchers will track how well the drug controls asthma symptoms over 56 weeks using patient questionnaires. The goal is to understand real-world treat…

This study tests a new medicine called lunsekimig in adults aged 40 to 80 with COPD that is not well controlled despite standard treatments. The drug is given as a shot and compared to a placebo to see if it can reduce the number of moderate-to-severe COPD flare-ups over about a …

This study tests whether dupilumab, an injectable drug, can reduce mucus blockages in the lungs of people with moderate-to-severe COPD. About 218 adults aged 40 to 85 who smoke or used to smoke will receive either dupilumab or a placebo for 24 weeks. The main goal is to see if th…

This study tests a new medicine called verekitug in 666 adults with moderate-to-severe COPD, a long-term lung disease. The goal is to see if it can safely reduce the number of serious flare-ups and improve breathing. Participants will receive either the drug or a placebo, and all…

This study tests whether a combination of two drugs (ensifentrine and glycopyrrolate) given through a nebulizer can improve lung function better than either drug alone in people with COPD. About 480 adults will take part. The goal is to see if the combo helps patients breathe eas…

This study tests a home-based coaching program for 300 adults with COPD, focusing on symptom management, medication use, and exercise. Health coaches will help participants identify and address barriers to better breathing, with the goal of reducing hospital visits and improving …

This study tests an experimental tablet called RSS0343 in people with chronic obstructive pulmonary disease (COPD). The goal is to see if the drug can reduce the number of moderate or severe flare-ups over 48 weeks. About 237 adults aged 40 to 80 with COPD will take either the ta…

This study tests a triple-combination inhaler (BGF MDI) in 56 adults with COPD and hyperinflation (trapped air in the lungs). The goal is to see if the inhaler improves both lung function and heart function compared to a placebo. Participants will use the inhaler or placebo for a…

This study tests an experimental drug called CM326 in people with moderate to severe COPD. The goal is to see if it can reduce the number of serious flare-ups and improve lung function. About 318 adults aged 40-85 will receive either the drug or a placebo for up to a year, with f…

This study tests a one-time treatment called lung denervation for people with COPD. The procedure targets nerves in the lungs to help open airways and improve breathing. Researchers will compare lung function in 200 adults who receive the treatment plus standard care versus those…

This study tests a new medicine called lunsekimig in adults aged 40-80 with COPD that is not well controlled, especially those with a type of inflammation called eosinophilic. The goal is to see if it can reduce the number of moderate-to-severe flare-ups and improve breathing ove…

This study looks at the long-term safety of astegolimab in people with chronic obstructive pulmonary disease (COPD). Participants must have already completed a one-year treatment period in a previous study. The main goal is to track any side effects over an extended time.

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve exercise ability in people with severe high blood pressure in the lungs caused by COPD. About 200 adults will receive either tadalafil or a placebo pill for 16 weeks. The main goal is to see if tho…

This study tests whether a low dose of morphine can help people with severe COPD who need a breathing mask (non-invasive ventilation) during a flare-up. The goal is to reduce early failure of the mask by easing pain, shortness of breath, and anxiety. About 24 adults will take par…

This study tests an inhaled drug called GDC-6988 in people with lung conditions that cause thick mucus, such as COPD and non-cystic fibrosis bronchiectasis. The main goals are to check the drug's safety and how well it works. About 128 adults with stable disease will take part.

This study tests a short, intensive pulmonary rehab program for people who smoke and have a lung nodule suspicious for cancer. Participants will do exercise training and get help to quit smoking before their lung cancer treatment. The goal is to see if this program is practical a…

This study tests whether a dry powder form of ivy extract (Syrup Prospan) works better than a common medication called NAC for reducing cough and mucus in people with COPD. About 100 adults with stable COPD will take one of the two treatments for a set period. The goal is to see …

This study tests whether a specific type of breathing exercise (functional inspiratory muscle training) can improve breathing, daily function, and quality of life in people with COPD. About 51 participants will be assigned to different training programs. The goal is to see if the…

This study explores whether inhaling menthol can quickly relieve shortness of breath in healthy adults and people with COPD. Researchers will measure brain and breathing responses during exercise and breathing tests. The goal is to understand how menthol works, so it can be devel…

This study tests a type of strength training called maximal strength training (MST) in 20 people with COPD. MST uses heavy weights with fast movements to improve muscle power and walking efficiency. Researchers want to see if MST helps patients breathe easier, feel less tired, an…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for 6 months, and n…

This study tests whether adding electrical stimulation to standard pulmonary rehabilitation can improve lung function and reduce restless leg symptoms in people with COPD. 60 participants will receive electrode patches on their chest and leg muscles alongside usual care. The goal…

This study looks at whether walking on an incline is better than walking faster on flat ground for people with COPD. The goal is to help patients feel less short of breath during exercise and improve their walking time. About 54 veterans with COPD will take part in treadmill test…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and weight loss, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks and be monitored for side …

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This study tests whether sildenafil, a pill that widens blood vessels in the lungs, can help people with mild COPD exercise longer and feel less short of breath. Researchers will measure exercise capacity and breathing patterns in 160 participants. The goal is to see if improving…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study is testing a new tool called CLEAR to see if it can better predict when people with severe COPD can safely stop using a breathing machine. Researchers will study 400 adults in the ICU who are ready to try breathing on their own. The goal is to improve decision-making a…

This study is gathering information from 470 adults with various inflammatory lung diseases, including asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze medical history, lung function, and other health data to identify different disease pa…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart and blood vessels. Researchers will compare 240 adults aged 40-79 with one or both conditions to understand why heart problems are more common in overlap syndrome. They will also …

This study aims to identify risk factors—including genetic ones—that make some people with COPD more likely to have severe flare-ups. By following 200 adults aged 40 and older with COPD, researchers hope to learn who needs more intensive care. The goal is to create personalized t…

This study looks at why some people hospitalized for a severe COPD flare-up have low levels of a certain white blood cell (eosinopenia) and how long it takes for those levels to return to normal. Researchers will track 200 patients to find patterns and recovery times. The goal is…

This study is testing a wearable device called C-mo System to see how well it can automatically detect and describe coughs in people with conditions like asthma, COPD, or chronic cough. About 300 participants aged 2 and older will wear the device for 24 hours and complete diaries…

This study looks at how the heart and lungs work during exercise in young people (ages 8-25) who have survived a heart transplant, leukemia, or were born with chronic lung disease. Researchers will use special tests to measure oxygen use and heart function while participants exer…

This study aims to understand why some COPD patients benefit from inhaled steroids (ICS) while others do not, by looking at molecular changes in the body. Researchers will recruit 135 former smokers with stable COPD who are already on dual bronchodilators. Participants will be gr…

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, heart failure, or high blood pressure. Researchers will measure blood flow and blood pressure before and after exercise in healthy volunteers and patients. Th…

This early-stage study tests whether a new inhaler spray called TQC3302 is safe and how it moves through the body. It involves 57 healthy adults in China, not people with COPD. The goal is to check for side effects and measure drug levels, not to treat the disease.

This study looks at how well lung cells can repair themselves in smokers with and without COPD compared to non-smokers. Researchers will take lung tissue from 186 people having surgery for suspected cancer. They will grow the cells in the lab to see how many healing structures (o…

This study aims to find genetic factors that make some people develop severe COPD at a young age (under 53). Researchers will analyze DNA from 2,000 participants to understand why some smokers get the disease while others don't. The study does not test any treatment—it only obser…

This study tests two ways to encourage people with COPD to attend pulmonary rehabilitation after a flare-up: watching videos of other patients sharing their rehab success stories, or getting phone coaching from someone who has been through it. Researchers will compare these appro…

This study aims to better understand the physical causes of certain patterns seen on lung ultrasound images in people with interstitial lung disease or COPD. Researchers will compare ultrasound findings with CT scans in 25 patients to link artifacts to specific lung changes. The …

This study is building a large registry of 3,000 people with emphysema or COPD, plus a control group without lung disease. Researchers will collect DNA, lung function tests, and medical history to better understand the disease and identify candidates for future treatment trials. …

This study looks at how immune cells behave in lung cancer, COPD, and sarcoidosis. Researchers want to understand why some people don't respond to immunotherapy. The goal is to gather knowledge that could lead to more personalized treatments in the future. About 425 participants,…

This study looks at how chronic obstructive pulmonary disease (COPD) changes the way people walk and move in daily life. Researchers will measure foot pressure, heart and lung function, and walking ability in 60 adults aged 45 to 65. The goal is to find better ways to evaluate an…

This study looks at people who are already getting lung cancer screening to find and track those who also have COPD. Researchers will collect information on symptoms, lung function, and CT scans from 420 participants. The goal is to better understand and manage COPD in this group…