BREAST NEOPLASMS

This study tested whether adding palbociclib (a targeted cancer drug) to standard hormone therapy (letrozole) helps Asian postmenopausal women with a certain type of advanced breast cancer (ER+/HER2-). The trial involved 340 women who had not received prior treatment for their ad…

This study compared two radiation methods for people with early-stage breast cancer: a shorter, more focused radiation (accelerated partial breast irradiation) versus standard whole breast radiation. The goal was to see which causes fewer side effects like skin problems, breast s…

This early-stage study tested a new drug called AZD6244 combined with standard chemotherapy in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researchers …

This study tested leflunomide, a pill usually used for arthritis, in 17 women with metastatic triple negative breast cancer (a fast-growing type). The goal was to see if it is safe and can help control the cancer. The drug works by blocking a protein the cancer needs to grow.

This early-phase study tested a new drug called H3B-6545 in 33 Japanese women with a common type of breast cancer (ER-positive, HER2-negative). The main goal was to see if the drug is safe and tolerable, and to find the right dose for Japanese patients. Participants had already t…

This study tested several immunotherapy-based drug combinations in 144 people with advanced hormone receptor-positive, HER2-negative breast cancer that had worsened after initial treatment with CDK4/6 inhibitors. Participants received either a standard hormone therapy (fulvestran…

This study tested whether an AI program called CadAI-B Dx helps doctors better detect breast cancer on ultrasound images. Researchers compared how 16 doctors performed with and without the AI's help, using 797 cases (350 with cancer, 447 benign). The goal was to see if the AI imp…

This study tested whether a special 3D ultrasound technique called shear wave elastography can predict how well breast cancer responds to chemotherapy before surgery. Researchers measured tumor stiffness in 140 women with locally advanced breast cancer at several points during tr…

This study tested whether a fast (abbreviated) breast MRI can detect cancers that were not seen on a standard mammogram in women who had previously undergone breast-conserving therapy for breast cancer. Researchers recruited 184 women who had a negative mammogram within the past …

This study tested an AI system called Carebot AI MMG to see if it can detect breast cancer from mammograms as accurately as human radiologists. Researchers looked at 222 past mammograms from four screening centers. The AI classified each exam as low, medium, or high risk, and its…

This study tested whether a contrast-enhanced mammogram (angiomammography) can predict if breast cancer will fully disappear after chemotherapy. 67 women with breast cancer had imaging after two rounds of chemo. The goal was to see if this method could identify non-responders ear…

This study tested whether injecting a local anesthetic (ropivacaine) into the surgical area during breast cancer surgery could prevent chronic breast pain that sometimes follows. Researchers compared 260 patients who received either ropivacaine or a placebo (salt water) during su…

This study tested whether a 12-week home-based program of walking and resistance band exercises could improve physical fitness, fatigue, and quality of life for 36 breast cancer patients in Indonesia. Participants used pedometers and resistance bands at home, with weekly phone ch…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study looked at two ways to manage pain after major breast cancer surgery: a nerve block (ESPB) and an IV lidocaine drip. 80 patients took part. The goal was to see which method helps patients recover better and with less pain.

This study looked at whether starting a tailored exercise program before breast cancer treatment can lessen heart damage and other side effects compared to exercising only during treatment. It involved 100 women recently diagnosed with breast cancer. The goal was to see if early …

This study tested a special program to help breast cancer patients manage joint and muscle pain caused by hormone therapy. The program was adapted to fit different cultural backgrounds. Researchers compared patients who received this program with those who got standard care to se…

This study looked at small molecules called metabolites in breast cancer tumors to find patterns that could help understand the disease better. Researchers analyzed 52 tumor samples and some blood samples from patients who had surgery. The goal was to identify possible biomarkers…

This study tracked 80 Egyptian women with HER2-positive breast cancer to see how well anti-HER2 drugs like trastuzumab work in everyday care. Researchers measured survival, cancer progression, and side effects. The goal was to understand how these treatments perform in this speci…

This completed study looked at medical records of 1128 Australian patients with advanced or metastatic breast cancer to see how doctors prescribe a class of medicines called CDK4/6 inhibitors, including palbociclib. Researchers examined patient characteristics, dosing patterns, a…

This study observed 440 adults in Poland with advanced HR+ HER2- breast cancer to understand how doctors treat the disease in everyday practice. Researchers tracked treatment choices, changes over one year, and how they relate to patient characteristics and guidelines. The goal w…

This study looked at 729 breast cancer patients who had surgery followed by radiation. Researchers checked their thyroid function before and after treatment to see how many developed an underactive thyroid (hypothyroidism). The goal was to find out which patients are at higher ri…

This study examined the vaginal microbiome—the collection of bacteria and other microbes—in 35 women with breast cancer receiving hormone therapy. Researchers wanted to see if changes in these microbes relate to vaginal dryness and sexual health. Participants provided vaginal swa…

This study involved 77 women to determine the minimum number of tissue samples needed for a reliable diagnosis when using contrast-enhanced stereotactic biopsy (CESB) for breast lesions only visible on contrast images. Researchers measured the diagnostic yield per sample and trac…

This study reviewed medical records of over 500 women in Gulf countries with advanced breast cancer that was previously labeled as HER2-negative. Researchers re-tested old tumor samples to find out how many actually had a newer subtype called HER2-low. The goal was to better unde…

This study looked at how breast cancer treatments affect sexual health in 25 women. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal was to understand how these factors …

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This study reviewed medical records of 258 adults in Gulf countries (like Saudi Arabia and UAE) who took palbociclib for advanced HR+/HER2- breast cancer. Researchers collected information on patient characteristics, treatment patterns, and outcomes like how long the cancer staye…

This study looked at how common BRCA1 and BRCA2 gene mutations are in Hispanic/Latino women with breast cancer. Researchers collected saliva samples and medical history from 266 participants to better understand these mutations in this group. No treatment was given; the goal was …

This study tested whether a smartphone app could help monitor side effects in 28 women with metastatic breast cancer who were taking oral chemotherapy drugs like palbociclib, everolimus, or capecitabine. The goal was to see if the app could reduce the number of calls to nurses an…

This study looked at whether people with unstable living conditions are more likely to be diagnosed with advanced breast cancer. Researchers compared 684 patients with early-stage versus late-stage breast cancer. They found that social fragility may be linked to a later diagnosis…

This study looked at whether a special 'remission' consultation helps women feel better after finishing breast cancer treatment. Fifty patients who had completed chemotherapy or radiation joined the study. Researchers checked their quality of life and body image at 3, 6, and 12 m…

This study looked at why some women have dense breasts on mammograms and why that increases their risk of breast cancer. Researchers collected tissue samples, medical records, and health updates from 466 women aged 40-65 who were having a breast biopsy. The goal was to understand…