BREAST NEOPLASMS

This early-phase study tests an oral drug called LY3484356 in 17 Chinese patients with advanced ER+/HER2- breast cancer. The main goals are to see how the drug moves through the body and to check its safety. Researchers will also look for signs that the drug can shrink tumors or …

This phase 3 trial tests a new oral hormone therapy called imlunestrant against standard hormone therapies (like tamoxifen or aromatase inhibitors) in 8,000 people with ER+/HER2- early breast cancer who have already had 2-5 years of hormone therapy and are at higher risk of recur…

This early-phase study tests a new drug called E7090, alone or with other cancer medicines, in people with a common type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and understand side effects. About 51 participants will take part to guide future r…

This study is for postmenopausal women with a common type of breast cancer (hormone receptor positive, HER2 negative) that hasn't spread. It compares the usual chemotherapy before surgery to a combination of two targeted pills (ribociclib and letrozole). The goal is to see if the…

This study tests a new drug called BT8009, given alone or with another drug (pembrolizumab), in people with advanced solid tumors (like bladder, breast, lung, or ovarian cancer) that have a protein called Nectin-4. The main goals are to check safety, find the right dose, and see …

This early-phase trial tests the safety of combining abemaciclib with various other cancer drugs (like letrozole, tamoxifen, or trastuzumab) in 198 people with breast cancer that has spread. The goal is to find safe combinations that may help control the disease. Participants hav…

This Phase 2 trial tests whether adding an immunotherapy drug called IRX 2 to standard pembrolizumab (Keytruda) and chemotherapy can improve the immune system's ability to attack triple negative breast cancer before surgery. The study involves 12 adults with previously untreated …

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This early-stage study tests whether using focused ultrasound (sound waves) together with a low dose of chemotherapy can help the body's immune system fight breast cancer more effectively. About 32 people with early-stage breast cancer will receive one or both treatments before s…

This early-stage study tests an experimental pill, ATV-1601, in adults with advanced solid tumors or certain breast cancers that have a specific AKT1 gene change. The main goals are to find a safe dose and check how the drug moves through the body. About 134 participants will tak…

This phase 3 study tested whether adding the drug abemaciclib to standard hormone therapy (fulvestrant) helps women with a common type of advanced breast cancer (HR+, HER2-) live longer without their cancer growing. About 669 women took part, receiving either the combination or f…

This study compares a 1-week radiation course to a standard 3-week course for women with node-positive breast cancer. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back while reducing the risk of lymphedema (arm swelling). About…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with a common type of advanced breast cancer (HR+/HER2-) live longer without their cancer getting worse. About 340 participants who have already tried hormone therapy wil…

This early-stage study tests the safety of tucatinib in about 25 Chinese patients with advanced HER2+ breast, stomach, or colorectal cancer that has worsened after standard treatments. Researchers will monitor side effects and how the drug moves through the body. The goal is to s…

This study tests whether a drug called trastuzumab deruxtecan (T-DXd), given alone or with other medications before surgery, works better than standard chemotherapy for people with high-risk HER2-positive early breast cancer. About 927 adults will take part. The main goal is to s…

This study tests whether a shorter, more focused radiation treatment (accelerated partial breast irradiation) after breast-conserving surgery can effectively control cancer in the breast and nearby lymph nodes for people with early-stage breast cancer. About 537 participants with…

This study tests whether adding a targeted drug (PD 0332991) to standard hormone therapy (anastrozole) before surgery can better stop breast cancer cell growth in women with early-stage ER+ HER2- breast cancer. About 84 women with stage 2 or 3 disease will receive the combination…

This early-stage study tests a new drug (H3B-6545) combined with an existing drug (palbociclib) in women with advanced or metastatic ER+ HER2- breast cancer. The main goal is to find the safest dose and understand side effects. About 31 women who have already tried other treatmen…

This study tests a new drug called PF-07220060 in people with advanced solid tumors, including breast, prostate, lung, and liposarcoma cancers. The drug is given alone or with hormone therapies to see if it is safe and works. About 362 participants will take part to find the best…

This study tests three drugs—durvalumab, olaparib, and cediranib—given together to people with advanced solid tumors or recurrent ovarian cancer. The goal is to see if these combinations can shrink tumors or slow cancer growth. Participants take the drugs by IV or mouth daily, an…

This study tests whether adding alpelisib to standard fulvestrant therapy can delay cancer growth in Chinese men and postmenopausal women with a certain type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that worsened after prior hormone therapy. About 69 partici…

This study compares two imaging methods—breast ultrasound and breast MRI—to see which is better at detecting new breast cancers in women with dense breasts who have already had breast cancer. About 1,756 women will be randomly assigned to get either an abbreviated MRI or a full M…

This study tests whether contrast-enhanced mammography (CEM) finds breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women ages 30-85 will get both types of mammograms to compare detection rates and false alarms. The …

This study tests whether combining pain neuroscience education (teaching patients about how pain works) with a gradual, timed increase in physical activity can reduce chronic pain in breast cancer survivors. About 122 survivors who have finished cancer treatment will be randomly …

This study aimed to see if a physical therapy program focused on neck exercises could improve motor control, reduce pain, and enhance mood and quality of life in women who had breast cancer at least five years ago. Participants were to be adults over 18 with stage I to IIIA breas…

This study looks at whether a combination of pain neuroscience education and motivational interviewing can reduce chronic pain in breast cancer survivors who feel a sense of injustice about their pain. 156 women who have finished primary cancer treatment will be randomly assigned…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study is testing commercially available antibodies to see if they can identify breast cancer markers in blood samples. Researchers will collect blood from 84 people, including breast cancer patients and healthy volunteers. The goal is to improve detection of circulating tumo…

The FATLAS study is looking at how body fat (adiposity) influences breast cancer at both the whole-body and cellular levels. Researchers will enroll 150 breast cancer patients with different body types (lean, overweight, obese) and collect blood, tumor tissue, and body measuremen…

This study looks at how breast cancer and its treatments impact the quality of life for patients in Martinique. Researchers will survey 133 adults with invasive breast cancer to understand their physical and emotional well-being, as well as how long treatment takes. The goal is t…

This study looks at whether checking lymph nodes for cancer during breast cancer surgery helps surgeons decide on the spot if more lymph nodes need to be removed. About 142 women with breast cancer who haven't had prior treatment will be randomly assigned to either have their lym…

This study looks at whether certain older women with a very low-risk type of breast cancer can safely skip radiation after lumpectomy. The women are postmenopausal, have hormone receptor-positive, HER2-negative tumors, and a low Oncotype DX score. Instead of radiation, they will …

This study follows over 1,400 patients in Germany and Austria with HR+/HER2- advanced breast cancer who are receiving standard first-line treatment with palbociclib plus hormone therapy. Researchers are collecting real-world data on how long the cancer stays controlled and overal…

This study looks back at 88 women who had two-stage breast reconstruction after mastectomy for breast cancer. It compares complication rates between nano- and microtextured tissue expanders and checks how prior radiotherapy affects outcomes. The goal is to find which expander typ…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This study uses tumor and blood samples from 1,000 breast cancer patients to create a model that predicts how well immunotherapy will work. Researchers will analyze genes, proteins, and other markers to find patterns linked to treatment success. The goal is to help doctors choose…

This study collects blood and saliva samples from people with cancer and their relatives to learn about genetic causes of cancer. Researchers will store these samples to study inherited cancer risks. About 992 participants will provide samples and family cancer history. The goal …

This study looks at whether it is safe to have an MRI scan when you have breast tissue expanders in place. About 68 people with these expanders will be scanned, and researchers will check for any burning, heating, or pain. The goal is to see if MRI can be done safely in this grou…

This study surveys 3,000 women aged 40 and older in Chinese communities to find out how many regularly perform breast self-exams and what factors influence their practices. Researchers use a health belief model to understand awareness, barriers, and motivations. The goal is to id…