BREAST NEOPLASMS

This early-phase study tests a new drug (H3B-6545) combined with palbociclib in women with advanced or metastatic ER+ HER2- breast cancer. The main goal is to find the safest dose and understand side effects. About 31 women who have already received prior treatment will participa…

This study tests whether adding alpelisib to standard fulvestrant therapy can delay cancer growth in Chinese men and postmenopausal women with a certain type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that worsened after prior hormone therapy. About 69 partici…

This study tested whether adding the drug abemaciclib to standard hormone therapy (fulvestrant) helps women with a common type of advanced breast cancer (HR+, HER2-) live longer without their cancer growing. About 669 women took part, and most received the combination. The goal w…

This early-phase study tests a new drug called LY3484356 in Chinese patients with a specific type of advanced breast cancer (ER+/HER2-). The main goal is to see how the drug moves through the body and how safe it is. Researchers will also check if the drug can shrink tumors. The …

This early-phase study tests a new drug called E7090, alone or with other cancer medicines, in people with a specific type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and understand side effects. About 51 participants will take part to help guide f…

This study tests three drugs—durvalumab, olaparib, and cediranib—in different combinations for people with advanced solid tumors, including ovarian, breast, lung, prostate, and colorectal cancers. The goal is to see if these combinations can shrink tumors or slow cancer growth. P…

This study tests whether a combination of two hormone-targeting drugs (ribociclib and letrozole) can work as well as chemotherapy before surgery for postmenopausal women with a common type of breast cancer (hormone receptor positive, HER2 negative). About 100 women with stage II …

This study compares breast ultrasound and MRI to see which is better at finding cancer in women with dense breasts who have had breast cancer before. About 1,756 women are taking part. The goal is to improve how we screen for new cancers in this high-risk group.

This study aimed to see if a physical therapy program focused on neck control exercises could help long-term breast cancer survivors (at least 5 years after diagnosis) improve neck movement, reduce pain, and feel better overall. The program was designed for survivors with stage I…

This study tests a new approach for breast cancer survivors who have long-term pain. Instead of just giving information, the program combines pain neuroscience education (teaching how the brain processes pain) with a gradual return to activity. About 122 survivors will be randoml…

This study uses tumor and blood samples from 1,000 breast cancer patients to create a model that predicts how well immunotherapy will work. Researchers analyze genes, proteins, and other markers to identify who is likely to respond. The goal is to help doctors choose the best tre…

This study surveys 3,000 women aged 40 and older in Chinese communities to understand their awareness and practice of breast self-exams. Researchers use a health belief model to identify factors that influence whether women perform regular self-exams. The goal is to find gaps in …

This study aims to understand why some families have a higher chance of developing cancer. Researchers are collecting blood and saliva samples from about 992 people with cancer and their relatives. The samples will be stored and used later to study genetic links to cancers like b…

This study looks at whether certain women with early-stage breast cancer can skip radiation after a lumpectomy. The women in the study are postmenopausal, have a specific low-risk type of breast cancer, and plan to take hormone therapy. Researchers will follow them for 10 years t…

This study reviews medical records of 88 women who had two-stage breast reconstruction after mastectomy for breast cancer. Researchers compare complications between nano- and microtextured tissue expanders and examine how prior radiotherapy affects outcomes. The goal is to unders…

This study looks at whether certain lab-made antibodies can find breast cancer markers in blood samples. Researchers will collect blood from up to 84 people, including breast cancer patients and healthy volunteers. The goal is to improve how we detect cancer cells circulating in …