Radiation-Free breast cancer treatment: a new option for older women?
NCT ID NCT02400190
First seen Oct 31, 2025 · Last updated Jun 21, 2026 · Updated 31 times
Summary
This study looks at whether certain older women with a very low-risk type of breast cancer can safely skip radiation after lumpectomy. The women are postmenopausal, have hormone receptor-positive, HER2-negative tumors, and a low Oncotype DX score. Instead of radiation, they will take hormone therapy alone. Researchers will track them for at least 10 years to see if the cancer comes back in the same area.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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East Carolina University
Greenville, North Carolina, 27853, United States
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Harvard University
Cambridge, Massachusetts, 02138, United States
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Johns Hopkins University
Baltimore, Maryland, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Northwell Health
Lake Success, New York, 11042, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
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Stanford University
Stanford, California, 94305, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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Yale University
New Haven, Connecticut, 06520, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
endocrine therapy alone without radiotherapy
What this could lead to
If successful, this could show that many older women with low-risk breast cancer can avoid radiation and its side effects, relying only on hormone therapy.
What could go wrong
This is an early-stage observational study with only 202 participants. It is not a randomized trial, so results may not be definitive. There is a risk that skipping radiation could lead to higher recurrence rates.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.