BREAST NEOPLASMS

This study follows about 3,250 people with HR+/HER2- early breast cancer who are at high risk of recurrence. Participants take ribociclib (Kisqali) plus an aromatase inhibitor as part of their routine care. Researchers will track how well the treatment works in real life, its sid…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study is testing whether a simple blood test that looks for cancer DNA can help doctors decide when to start a targeted therapy (CDK4/6 inhibitor) in people with intermediate-risk HR+ HER2- breast cancer. About 725 participants will have their blood tested every 3 months for…

This study tests whether adjusting chemotherapy doses based on a person's DPYD gene test can lower the risk of severe side effects. About 100 cancer patients starting treatment with fluorouracil or capecitabine will be assigned to either standard dosing or a reduced dose based on…

This study tests a drug called disitamab vedotin in 100 adults with advanced HER2-positive breast cancer that has spread and is hard to treat. Participants receive the drug into a vein every two weeks. Researchers will check if the drug shrinks tumors and monitor for side effects…

This Phase 3 trial tests whether adding the experimental drug BNT327 to standard chemotherapy helps people with advanced triple-negative breast cancer that cannot be treated with current immunotherapy. About 558 participants will be randomly assigned to receive either BNT327 plus…

This study tests a new drug, patritumab deruxtecan, against standard chemotherapy or another drug for people with a common type of advanced breast cancer (HR+/HER2-). The goal is to see if the new drug helps people live longer or keeps the cancer from growing. About 1000 particip…

This study tests whether tirzepatide, a weight-loss medication, combined with standard hormone therapy can help clear tiny amounts of cancer DNA from the blood of people with obesity or overweight who have had hormone-positive, HER2-negative, node-positive early breast cancer. Th…

This study tests a combination of two drugs, disitamab vedotin and tucatinib, for people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combo can shrink or control tumors and what side effects occur. About 172 adults with these …

This study is testing a handheld robotic tool called HandX to help surgeons perform a nipple-sparing mastectomy through a single small incision. The goal is to remove breast tissue while keeping the skin and nipple, leading to less scarring and better cosmetic results. About 15 w…

This study provides ongoing access to the drug niraparib for up to 30 people with ovarian or breast cancer who have already benefited from it in earlier studies. The main goal is to track long-term safety and side effects. Participants will continue their current treatment and be…

This study tests whether adding a new drug (LY4064809) to standard hormone therapy and CDK4/6 inhibitors can better control advanced HR+ HER2- breast cancer with a PIK3CA mutation. About 920 adults who have not had prior treatment for advanced disease will participate. The goal i…

This study tests a drug called patritumab deruxtecan in people with HER2-positive breast cancer that has spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and how safe it is. About 81 adults will take part. This is not a cure, but aims to co…

This study tests a new targeted therapy (Sac-TMT) added to standard chemotherapy and immunotherapy for people with high-risk, early-stage triple-negative or hormone-receptor-low breast cancer. The goal is to see if this combination destroys more cancer before surgery and helps pe…

This study tests whether adding a new drug (patritumab deruxtecan) to standard chemotherapy and immunotherapy can eliminate more cancer cells before surgery in people with high-risk early-stage triple-negative or hormone receptor-low/HER2-negative breast cancer. About 372 partici…

This study compares a combination of two drugs (elacestrant and capecitabine) to capecitabine alone in people with advanced estrogen receptor-positive breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to one of the two t…

This early-phase trial tests a new treatment for people with a type of stomach or esophageal cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells carrying a protein c…

This study is testing whether adding the drug dalpiciclib to standard hormone therapy can help keep early-stage HR+/HER2- breast cancer from returning. About 2000 women with stage II or III breast cancer will receive either a lower dose for 3 years or a higher dose for 2 years. R…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This study tests whether a daily pill (Z-endoxifen) plus a monthly shot (goserelin) can slow or stop estrogen-driven breast cancer growth in premenopausal women. About 87 participants will take the drugs for up to 24 weeks before surgery. The main goal is to see if the treatment …

This study tests a new drug called izalontamab brengitecan (BMS-986507) against standard chemotherapy in about 500 people with advanced triple-negative or ER-low breast cancer who cannot receive immunotherapy. The drug is designed to target and kill cancer cells while sparing hea…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study tests a new way of giving chemotherapy called adaptive therapy for people with advanced breast cancer that has gotten worse after standard treatments. The goal is to see if adjusting the dose over time can help control the cancer longer and with fewer side effects. Abo…

This early-phase study tests an experimental pill, CID-078, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the best dose. About 220 participants will take the drug by mouth, and researchers wil…

This phase 3 trial tests whether a new drug (MK-2870), alone or with another drug (pembrolizumab), works better than standard treatments for people with a common type of advanced breast cancer (HR+/HER2-). About 1,200 participants whose cancer has worsened after hormone therapy w…

This study is testing a new 3D automated ultrasound system called ATUSA to see how well it can image suspicious breast lesions. Up to 800 women with suspicious findings on standard imaging will get an ATUSA scan before their biopsy. The goal is to collect images and compare them …

This study tests two new radioactive imaging probes that target specific markers on breast cancer cells. Researchers will use PET/CT scans to see how well these probes find tumors and their spread in 200 women with breast cancer. The goal is to improve diagnosis and help guide tr…

This study looks at whether adding a special dye-enhanced mammogram every two years to the standard yearly 3D mammogram can find breast cancer more effectively in women who have already had breast cancer. The goal is to catch new cancers early while keeping false alarms low. Abou…

This early study tests a new radioactive imaging agent called [68Ga]Ga-DWJ155 in 36 adults with advanced breast cancer or non-small cell lung cancer. The goal is to see how well it highlights tumors on PET scans and to check its safety. It is a first-in-human trial, so results ar…

This pilot study compares two types of PET scans in 20 women with ER-positive breast cancer. The standard tracer (18F-FDG) sometimes misses cancer spread in this subtype. The new tracer (68Ga-FAPI-46) targets a protein on tumor-supporting cells and may find more lesions. Research…

This study tests whether an augmented reality (AR) system can help surgeons remove all breast cancer during breast-conserving surgery. About 94 women with breast cancer will be randomly assigned to have surgery guided by AR or by the usual ultrasound skin marking. The main goal i…

This study tests whether a home-based telerehabilitation program can prevent common complications like pain, shoulder stiffness, and arm swelling after breast cancer surgery. 155 women who have had a mastectomy or quadrantectomy will be randomly assigned to either the telerehabil…

This study tests whether a steroid mouthwash (dexamethasone) can reduce painful mouth sores caused by the cancer drug datopotamab deruxtecan. About 60 adults with advanced breast or lung cancer will use the mouthwash four times a day for the first few treatment cycles. The goal i…

This study tests whether a community-based exercise program can improve memory, attention, and brain health in women who have had breast cancer. About 160 survivors, aged 50 and older, will either take part in aerobic exercise or health education sessions. The goal is to see if p…

This study compares two exercise programs for women who have finished breast cancer treatment. One group does supervised resistance and relaxation exercises at a facility, while the other follows a home-based resistance routine. The goal is to see which approach better improves m…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study tests whether a program of exercise and personalized nutrition before breast cancer treatment (called prehabilitation) can help women recover faster and feel better. Researchers will measure fitness, strength, and quality of life in 66 women with early-stage breast can…

This study aims to understand how breast cancer cells change after chemotherapy by comparing genetic markers before and after treatment. Researchers will collect blood, breast tissue, and bone marrow samples from 300 people with stage II to IV breast cancer. The goal is to find m…

This study takes tumor samples from breast cancer patients whose cancer has spread to the brain or other organs. Researchers grow these samples into tiny 3D organoids in the lab and test different treatments on them. The goal is to see if the organoids' responses match how the pa…

This study follows 1,000 young women with breast cancer to learn more about preserving fertility and having healthy pregnancies. It collects data on which fertility treatments patients choose, how well they work, and the safety of cancer treatment during pregnancy. The goal is to…

This study looks at whether a protein called SGLT2 is linked to heart damage caused by a common type of breast cancer chemotherapy. Researchers will measure SGLT2 levels in blood and cells from 50 women with localized breast cancer before and after treatment. The goal is to find …

This study is testing new drug combinations for breast cancer to see which ones work best for different tumor types. It involves up to 5,000 people with early-stage or locally advanced breast cancer. Researchers use MRI scans and tissue samples before surgery to predict treatment…

This study watches how the lymphatic system changes after radiation therapy in 40 women with breast cancer. Researchers use a safe dye and special camera to see early signs of arm swelling (lymphedema). The goal is to find ways to predict and prevent this side effect in the futur…

This study tests a decision-making tool called BREASTChoice for breast cancer patients considering reconstruction after surgery. Twenty participants will use the tool on their phones and share their thoughts in interviews. Researchers will measure how much patients learn about re…

This study aims to develop a machine learning tool to predict heart damage in 600 cancer patients receiving certain chemotherapy drugs (anthracyclines or HER2-targeted therapies). Researchers will collect data over one year to see who develops heart problems. The goal is to creat…

This study follows 3,000 women with early-stage breast cancer to understand how local treatments like surgery and therapy affect their quality of life and cause side effects. Participants will complete surveys and undergo health checks, including heart and lung tests, over time. …

This study aims to understand why breast cancer risk and outcomes vary among different people. Researchers will collect blood, tissue, and survey data from 800 adults in South Florida, including those with suspicious breast findings or newly diagnosed breast cancer. By analyzing …

This study is a registry that collects information from about 1867 people with advanced or metastatic breast cancer. Researchers will track different breast cancer subtypes and patient characteristics to better understand the disease in real-world settings. No new treatments are …

This study is testing whether a detailed PET/MR scan using a radioactive tracer called fluorocholine can predict the molecular subtype and likely outcomes of breast cancer. Researchers will scan 195 women before they start treatment and compare the images with their actual tumor …

This study follows 1600 breast cancer patients for up to 15 years after radiotherapy to see if newer, more precise radiation techniques lower the risk of heart disease. Researchers will compare heart problems in these patients to those in the general female population. The goal i…

This study is testing whether an artificial intelligence (AI) tool can accurately predict a woman's genetic risk of developing breast cancer by analyzing her family cancer history. Researchers will compare the AI's predictions with standard genetic test results in 800 women who h…

This study explores why some breast cancer patients get diarrhea from the drug abemaciclib while others don't. Researchers will compare the gut bacteria of 60 women who do and don't have this side effect. No new treatments are tested—just stool and blood samples are collected to …

This study follows 30 women having DIEP flap breast reconstruction after mastectomy. Researchers will measure inflammation and stress markers in blood samples taken before and after surgery. The goal is to learn how the body heals and what affects recovery, which may help improve…

This study enrolls 3,300 women with invasive breast cancer living in 59 North Carolina counties. It aims to understand how tumor biology, healthcare access, and patient behavior together affect outcomes. All participants receive a structured program to improve communication with …

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study is observing about 800 adults with advanced breast cancer (HER2-positive, low, or ultralow) who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers are tracking how long patients stay on the drug before switching treatment…

This study follows 100 women with early-stage breast cancer for two years after surgery and other treatments. Researchers will measure changes in muscle mass and body fat using a special scale. The goal is to understand how the body changes during recovery, which may help improve…

This study takes tumor samples from people with triple-negative breast cancer, colorectal cancer, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to provide person…

This study will test how well artificial intelligence (AI) can interpret breast ultrasound images using the latest BI-RADS criteria. Researchers will collect over 1,300 past ultrasound images with confirmed diagnoses and have expert radiologists annotate them. Then, various AI mo…