BREAST NEOPLASMS

This early-phase study tests a new drug, LY4337713, that delivers radiation directly to cancer cells with a specific protein called FAP. It is for adults with advanced or spread cancers like pancreatic, breast, ovarian, or colorectal cancer that have not responded to other treatm…

This study tests a new drug, MK-2870, alone or with another drug (pembrolizumab), against standard treatments for people with a common type of advanced breast cancer (HR+/HER2-). About 1,200 participants whose cancer has worsened after hormone therapy will be randomly assigned to…

This study tests a medicine called disitamab vedotin in people with advanced breast cancer that has HER2 on the tumor cells and has not responded well to prior treatments. About 100 adults will receive the drug as an IV infusion every two weeks. Researchers will monitor safety an…

This study looks at whether a blood test (Signatera) can help decide when to start a targeted therapy (CDK4/6 inhibitor) in people with intermediate-risk HR+/HER2- breast cancer. Participants will either start the extra therapy if the blood test shows signs of remaining cancer, o…

This study observes how well Kisqali combined with hormone therapy works in real-world settings for people with a common type of early breast cancer that has a high chance of coming back. Researchers will track about 3,250 participants to see how long they stay cancer-free, any s…

This study compares two treatments for advanced estrogen receptor-positive (ER+) breast cancer that has stopped responding to CDK 4/6 inhibitors. About 297 participants will receive either a combination of capecitabine (chemo) and elacestrant (a hormone-blocking drug) or capecita…

This study tests whether adding a targeted therapy (Sac-TMT) to standard chemo and immunotherapy before surgery helps more people with high-risk early-stage triple-negative or hormone-receptor-low breast cancer achieve a complete response (no cancer left in breast or lymph nodes)…

This study tests whether adding a new drug (LY4064809) to standard hormone therapy and a CDK4/6 inhibitor can better control advanced HR+ HER2- breast cancer with a PIK3CA mutation. About 920 adults who have not yet received treatment for advanced disease will participate. The go…

This study tests a combination of two drugs—disitamab vedotin and tucatinib—in people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combo is safe and shrinks tumors. About 172 adults will take part. This is not a cure; it aims …

This study tests whether a daily pill called (Z)-endoxifen, combined with a monthly injection that temporarily stops the ovaries from making estrogen, can slow or stop the growth of estrogen-receptor-positive breast cancer in premenopausal women. About 87 women will receive the t…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced breast, colorectal, prostate, or endometrial cancer that has spread. The goal is to see if the drug is safe and shrinks tumors. …

This early-stage study tests an experimental oral drug called CID-078 in people with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the best dose. About 220 adults with cancers like lung, breast, or neuroe…

This study tests whether adding a new drug (patritumab deruxtecan) to standard chemotherapy and immunotherapy before surgery can eliminate more cancer cells in people with high-risk early-stage triple-negative or hormone-receptor-low breast cancer. About 372 participants will be …

This study tests a new way of giving chemotherapy called adaptive therapy for people with advanced breast cancer that has gotten worse after standard treatments. The goal is to see if this approach can delay the cancer from growing again. About 192 adults will take part in this p…

This study is testing a new 3D breast ultrasound system called ATUSA to see if it can help doctors find breast cancer more accurately. About 800 women with suspicious breast findings (BI-RADS 4 or 5) will get the scan before their biopsy. The goal is to compare the ultrasound ima…

This study is testing two new imaging agents that light up specific markers on breast cancer cells during a PET/CT scan. The goal is to see if these probes can find tumors and their spread more accurately than current methods. About 200 women with breast cancer or suspected breas…

This study is testing a new AI tool that collects family cancer history through WhatsApp to predict a woman's genetic risk for breast cancer. Researchers will compare the AI's predictions with standard genetic tests in 800 women already identified as high-risk by their doctors. T…

This study tests whether an augmented reality (AR) system can help surgeons remove breast cancer more accurately than the usual ultrasound method. About 94 women with breast cancer will be randomly assigned to either AR-guided or standard surgery. The main goal is to see if the A…

This study tests whether a newer PET tracer, 68Ga-FAPI-46, can find more cancer spots than the standard tracer in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will get both types of scans. The goal is to see if the new tracer lead…

This study tests whether a telerehabilitation program, done at home after breast cancer surgery, can prevent common complications like pain, swelling, and limited shoulder movement. Researchers will compare a group that starts rehab right after surgery with a group that follows s…

This study compares two exercise programs for women who have finished breast cancer treatment. One group does therapist-led resistance and relaxation exercises at a facility, while the other follows a self-directed home exercise plan. The goal is to see which approach better impr…

This study looks at whether a program of exercise and healthy eating, started right after diagnosis and before treatment begins, can help women with breast cancer feel better and recover faster. About 66 women with early-stage breast cancer will take part. The program includes su…

This study follows 30 women aged 18-70 who are having DIEP flap breast reconstruction after breast cancer surgery. Researchers will take blood samples before and after surgery to measure markers of inflammation and stress. The goal is to learn more about how the body heals and wh…

This study follows 100 women with early-stage breast cancer for two years after surgery and other treatments. Researchers measure changes in muscle mass, body fat, and quality of life to better understand the long-term effects of cancer therapy. The goal is to gather information,…

This study aims to understand why breast cancer risk and outcomes differ among people. Researchers will collect surveys, blood, and tissue samples from 800 adults in South Florida. The goal is to identify genetic and non-genetic factors that may explain these differences.

This study follows 800 adults with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers will track how long patients stay on treatment, their quality of life, and an…

This study enrolls 3,300 women with invasive breast cancer in North Carolina to understand why some groups have worse outcomes. Researchers will collect biological samples and medical records, and all participants will receive a program to help them communicate better with their …

This study looks at why some breast cancer patients get diarrhea from the drug Abemaciclib while others don't. Researchers will compare the gut bacteria of 60 women who have diarrhea with those who don't, using stool samples. No new treatments are tested—the goal is to learn how …

This study is testing a mobile decision tool for breast cancer patients who have had surgery. 20 participants will use the tool and share their thoughts to help improve it. The goal is to make sure the tool is easy to use and helps patients understand their options for breast rec…

This study collects over 1,300 breast ultrasound images from past patients and open databases. Expert radiologists will label them, and then various AI models will try to classify the images. The goal is to see how accurate the AI is compared to human experts, which could help sp…