University Of Michigan Rogel Cancer Center

This study tests whether taking prednisone, a steroid, before and during radiation therapy can protect the liver in people with liver cancer. About 20 participants will take prednisone for a few days around their radiation sessions. The goal is to see if it reduces liver inflamma…

This early-stage trial tests the safety and best dose of gilteritinib, a drug already approved for leukemia, in 30 people with stage IV ALK-positive non-small cell lung cancer whose tumors stopped responding to other treatments. The goal is to see if the drug can control the canc…

This study tests a personalized approach to treating p16-positive oropharyngeal cancer (a type of throat cancer linked to HPV). The goal is to use less intense treatment—either surgery with tailored follow-up or customized chemoradiation—to maintain high cure rates while reducing…

This study looks at whether active surveillance (watching and not treating) is a safe and comfortable option for adults aged 65 and older with low-risk basal cell carcinoma, a slow-growing skin cancer that rarely spreads. Instead of standard treatments like scraping, burning, or …

This study tests a combination of two drugs, pembrolizumab and mogamulizumab, for people with advanced-stage cutaneous T-cell lymphoma (CTCL) that has come back or not responded to prior treatment. The goal is to see how many patients achieve a complete response (no detectable ca…

This study tests whether the immunotherapy drug pembrolizumab can shrink or control advanced or recurrent skin cancer near the eye. About 22 adults with this type of cancer will receive the drug. The goal is to see if the treatment can reduce tumors and help patients keep their e…

This study tests whether adding a fiber supplement called inulin gel to standard immunotherapy drugs (ipilimumab and nivolumab) can help control advanced kidney cancer better than immunotherapy alone. About 55 adults with kidney cancer that has spread or is locally advanced will …

This study tests the drug pacritinib in 100 people with T-cell lymphoma that has returned or not responded to prior therapy. The main goal is to see how many patients' tumors shrink or disappear. Participants will take the drug and be monitored for side effects and disease respon…

This study tests a combination of two drugs, ruxolitinib and enzalutamide, in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to find the safest dose and see if the combination can shrink tumors or lower PSA levels. About 2…

This study tests a drug called ivonescimab given before surgery for people with stage II to IV head and neck cancer that can be removed. The drug helps the immune system attack cancer cells. The goal is to see if it can shrink tumors and improve treatment results. About 28 adults…

This early-stage trial tests a new treatment for children and young adults (ages 3-39) with recurrent malignant brain tumors that can be surgically removed. The therapy uses two modified viruses injected into the tumor to kill cancer cells and train the immune system to attack th…

This study tests an experimental drug called ESK981 in people with advanced pancreatic cancer, certain neuroendocrine tumors, or neuroendocrine prostate cancer. Participants take ESK981 capsules in a 5-days-on, 2-days-off cycle. The main goal is to see if the drug can keep the ca…

This study tests whether adding a special potato starch and an iron-lowering drug to standard care can help people who receive a stem cell transplant for blood diseases. About 50 adults will take the combination to see if it reduces serious side effects like graft-versus-host dis…

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen in premenopausal women with breast cancer. Both drugs stop the ovaries from making estrogen, which can fuel cancer growth. The trial will test if leuprolide works as well as goserelin. Ab…

This study tests a new radioactive tracer called FAPI-04 to see how well it lights up high-grade neuroendocrine tumors on PET/CT scans. About 30 adults with these aggressive tumors will get one scan to measure tracer uptake in tumors versus normal tissues. The goal is to improve …

This study looks at whether different amounts of home treadmill exercise can help prevent colorectal polyps from returning in people with Familial Adenomatous Polyposis (FAP). About 32 participants will follow a personalized exercise plan for 26 weeks. Small tissue samples, blood…

This study tests whether a 12-week exercise program is practical and helpful for Black women who have finished breast cancer treatment. About 75 women will take part, with some starting exercise right away and others waiting. The goal is to see if the program improves strength, m…

This study tests whether a virtual diet program focused on lowering added sugar, increasing fiber, and eating more omega-3s can help cancer survivors manage nerve pain, numbness, and tingling caused by chemotherapy. About 50 adults who finished chemo at least three months ago and…

This study tests a decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms and helps patients discuss treatment options with their doctor. About 20 patients currently …

This study tests a short, virtual therapy called solution-focused brief therapy (SFBT-C) to see if it reduces anxiety and depression in teens and young adults who have had cancer. About 60 participants aged 15-39 who are currently distressed will receive either SFBT-C or standard…

This study tests whether a dietary supplement called resistant potato starch can help prevent joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 20 people with early-stage breast cancer or at high risk for it will take the starch dail…

This early-phase study is testing the safety of adding the drug ribociclib to standard radiation therapy for women with a high-risk type of breast cancer (HR+/HER2-). About 30 participants will take ribociclib daily for up to 6 weeks while receiving radiation. The main goal is to…

This study compares two radiation schedules for men whose prostate cancer has returned after surgery. One uses fewer, stronger doses (ultra-hypofractionated), the other uses standard moderate doses. The goal is to see which approach causes fewer bowel and urinary side effects two…

This study tests whether personalized diet advice from a registered dietitian can reduce fatigue and improve sleep and quality of life in lymphoma survivors. About 100 adults with persistent tiredness will receive 8 counseling sessions over 3 months by phone or video. The goal is…

This study is testing whether an 8-week exercise program, called prehabilitation, can improve heart fitness and reduce heart complications in people at high risk who are about to have a stem cell transplant. About 10 adults with at least one heart risk factor will take part. The …

This study looks at whether giving the chemotherapy drug paclitaxel over a longer time (2-3 hours) to cancer patients with low muscle mass can make the drug level in their blood similar to patients with normal muscle mass who get the standard 1-hour infusion. About 22 women with …

This study looks at whether a special lung scan (parametric response mapping) can help detect chronic lung injury early in people who have had a blood stem cell transplant. Researchers will follow 375 patients for one year to see if the scan can predict lung problems or death. Th…

This study tests whether online tools can help people with hereditary cancer syndromes share risk information with their relatives and encourage them to get genetic testing. About 500 participants (patients and their family members) will use a web-based platform to invite relativ…

This study looks at whether stool or blood samples can spot colon cancer or precancerous polyps as early as a colonoscopy. Researchers will collect samples from 1,200 adults, including those with cancer, polyps, or at risk. The goal is to find simple, non-invasive ways to screen …

This study looks at whether a blood test for tumor DNA can help doctors know early if chemotherapy is working for people with advanced leiomyosarcoma, a rare soft tissue cancer. Researchers will collect blood samples before and during treatment, along with tumor tissue and scans,…

This study tests a special needle that uses light and sound to check prostate tissue during a standard biopsy. The goal is to see if the probe can reliably tell the difference between healthy and cancerous areas without taking extra tissue samples. About 50 men scheduled for a pr…

This study looks at whether a blood test for tumor DNA (ctDNA) and detailed scans can help predict how well chemotherapy works in people with a rare soft tissue cancer called leiomyosarcoma. About 40 participants will give blood samples and have scans before, during, and after tr…

This study tests whether an online platform helps cancer patients track medication safety events and concerns while taking oral anticancer drugs at home. About 80 adults with lung, colorectal, breast, or prostate cancer will use the system to log symptoms and issues. Researchers …