BRAIN DISEASES

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for people recovering from a serious brain bleed (aneurysmal subarachnoid hemorrhage) after surgery. RIC uses a blood pressure cuff on the arm to create brief, harmless blood flow interruptions, w…

This study tests a special stent coated with rapamycin to treat narrowed brain arteries in people who still have symptoms despite medication. About 300 participants will receive the stent and be monitored for up to a year. The main goal is to see how many have a stroke or die wit…

This study tests whether injecting a clot-dissolving drug directly into the blocked brain artery can improve recovery for people with a medium vessel stroke. About 282 adults whose stroke is caused by a blockage in a medium-sized brain artery will receive either the drug injectio…

This early-stage trial tests a specially engineered virus, G207, in children and young adults (ages 3 to 21) whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is …

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults are being…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that offers a specialize…

This study looks at whether increasing physical activity using a motivational smartphone app can slow down cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease. Researchers will enroll 80 people with iRBD and 50 health…

This study tests whether combining virtual reality (VR) exercises with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who had a stroke at least three months ago. About 100 adults will be assigned to different therapy groups to see which ap…

This study is testing whether a smartphone app can help doctors better understand and treat depression by tracking symptoms every day. About 200 adults with depression will use the app or receive standard care. The goal is to see if the app leads to greater improvement in mood an…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people already scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to understand t…

This study looks at how blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to measure brain blood vessel function. They will compare 120 children with sickle cell disease to healthy children to…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel health in the brains of inactive older adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers. The goal is to fi…

This study tests whether a live video call between a neurologist and ambulance paramedics can improve the detection of strokes before reaching the hospital. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps paramedics use stroke s…

This study looks at a blood marker called BD-tau, which may show how much brain injury happens after a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults who had a stroke. The goal is to learn when the marker rises and how long it stays high, whic…

This study is tracking 350 stroke patients in the Asia-Pacific region to see how well a procedure called endovascular thrombectomy (clot removal) works outside of clinical trials. Researchers want to understand what helps or hinders recovery in everyday hospital settings. The goa…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…

This study tests a new method to improve brain MRI scans by reducing blurring caused by breathing. About 100 adults getting routine brain MRIs will have their scans processed with and without the new correction technique. The goal is to see if the corrected images are clearer and…

This study follows 5,000 adults in Hong Kong who either have or are at high risk for brain diseases like stroke and dementia. Researchers will collect medical records, surveys, and phone interviews over many years to identify what factors lead to these conditions. The goal is to …

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…