ADVANCED CANCER

This study tests a personalized vaccine made from a patient's own tumor mutations. It aims to train the immune system to fight advanced or high-risk solid tumors. Ten adults will receive the vaccine along with immune-boosting drugs. Researchers will check safety and whether the c…

This early-phase study tests the safety of combining two drugs, BMS-986504 and olaparib, in people with advanced solid tumors that have lost a gene called MTAP. The goal is to find safe doses and understand side effects. About 36 adults whose cancer has not responded to standard …

This early-phase study tests a new DNA-based medicine called SXRN in 28 people with advanced solid tumors who have not responded to standard treatments. The main goals are to check safety and find the best dose, while also seeing if it can improve appetite and physical function. …

This study tests a new drug called NUC-7738 in people with advanced solid tumours or lymphoma that have not responded to other treatments. The goal is to find the safest dose and see if it can shrink tumours, either alone or combined with another drug (pembrolizumab). About 135 a…

This study tests a new drug, MGC026, in 250 adults with advanced solid tumors that have not responded to other treatments. The goal is to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants receive the drug by IV and are closely monitored f…

This early-stage study tests a new drug called TJ033721 (givastomig) in people with advanced or metastatic solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 330 partici…

This study is testing a drug called toripalimab, which helps the immune system fight cancer. It is for people with advanced solid tumors that have specific gene changes (POLE or POLD-1) but not high microsatellite instability. The goal is to see if the drug can shrink tumors and …

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if…

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. AGX101 is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to check for sid…

This study offers continued treatment with certain cancer drugs for people with advanced or metastatic cancer who are already benefiting from them in earlier studies. The main goal is to monitor long-term safety, including side effects. About 50 adults will take part, and the stu…

This study is for people with advanced bile duct cancer (ICC) that cannot be removed by surgery. It tests a treatment that delivers chemotherapy directly to the liver (HAIC) along with drugs that boost the immune system. The goal is to see if this combination can shrink tumors an…

This early-stage study tests a new oral drug, TQB3122, in 86 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors or slow disease progression. Participa…

This early-phase study tests a new drug, OKI-219, designed to block a specific cancer-driving mutation (PI3KαH1047R). It is for people with advanced solid tumors or breast cancer that has not responded to other treatments. The study will first find the safest dose of OKI-219 alon…

This study is observing 800 Chinese adults with advanced HER2-positive or HER2-low breast cancer who are taking trastuzumab deruxtecan (T-DXd). Researchers will track how long the drug controls the cancer and note any side effects in real-world settings. The goal is to understand…

This study tests a new drug called ALK201 in people with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About 202 adults aged 18 to 75 will take part in this ea…

This study tests an experimental drug called ART0380, taken as a pill, for people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with standard chemotherapies (gemcitabine or irinotecan). About 442 …

This study tests a new drug called JZP815 in people with advanced or spreading solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to find a safe dose and see if the drug can shrink tumors. About 332 adults who have tried all other standard tre…

This study tests a new treatment for people with advanced pancreatic cancer whose tumors have a specific genetic change (KRAS G12V) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This study tests an inhaled therapy called KB707 for people with advanced solid tumors that have spread to the lungs. KB707 is a modified virus designed to trigger the immune system to attack tumors. The trial involves 250 adults who have not responded to or cannot tolerate stand…

This study tests an experimental drug called RBS2418, which works by helping the body's immune system fight cancer more effectively. It is given alone or with another cancer drug (pembrolizumab) to people with advanced solid tumors that have not responded to standard treatments. …

This early-stage trial tests a new drug, AWT020, in about 60 adults with advanced solid tumors or lymphoma that has not responded to standard treatments. The main goals are to check the drug's safety at different doses and to see how the body processes it. This study does not aim…

This study is for children and young adults with advanced or spreading solid tumors. It tests a new drug called repotrectinib combined with two chemotherapy drugs (irinotecan and temozolomide). The goal is to find the safest dose and see if the combination helps shrink tumors. Ab…

This early-phase trial tests a new drug (ASTX660) combined with an immunotherapy (pembrolizumab) in people with advanced solid tumors, including triple-negative breast cancer and cervical cancer. The goal is to see if the combination is safe and can help the immune system recogni…

This early-stage study tests a new drug called PHN-012, which is designed to deliver a powerful cancer-killing agent directly to tumor cells. It is for people with advanced colon, pancreatic, or lung cancer who have tried other treatments without success. The main goals are to ch…

This study tests a new daily pill, INX-315, in 150 people with advanced breast, ovarian, or other solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or control tumors. The study includes three parts: testing the…

This study tests a new experimental drug called CVM-1118 combined with the immunotherapy nivolumab in people with advanced liver cancer that cannot be removed by surgery. About 95 adults will receive the combination to see if it shrinks tumors and how long any benefit lasts. The …

This early-stage study tests a new drug called IMC-002 in about 62 adults with advanced solid tumors that no longer respond to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also measure how the drug moves through the body…

This study tests whether adding the experimental drug givastomig to standard immunotherapy and chemotherapy helps people with advanced stomach or esophageal cancer live longer without their cancer growing. About 180 adults whose tumors have certain proteins (CLDN18.2 and PD-L1) w…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This early-stage study tests a new drug, TQB3002, in 150 adults with advanced cancers that have not responded to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also measure how the drug moves through the body. This is …

This study tests whether using chemotherapy alone before surgery works as well as chemotherapy followed by radiation for people with advanced rectal cancer. About 540 adults with resectable tumors will be randomly assigned to one of the two treatment plans. The main goal is to se…

This study tests a new drug called TST001 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug targets a protein called Claudin18.2 found on some cancer cells. The main goals are to check safety, find the best dose, and see if it helps s…

This study tests a combination of three drugs—177Lu girentuximab, cabozantinib, and nivolumab—in people with advanced clear cell kidney cancer who have not had treatment before. The goal is to see if this mix can help control the cancer. About 100 adults will take part, and the s…

This phase 3 study compares a new two-drug immunotherapy (botensilimab + balstilimab) against the current standard treatment (chemotherapy plus nivolumab) in people with advanced or metastatic stomach or esophageal cancer that has a specific genetic feature (MSI-H/dMMR). The goal…

This study tests a new spiritual care program called PEACE for people with advanced cancer. The program involves talks with a chaplain and a doctor to help patients explore how their faith affects their medical choices. The goal is to see if this approach is practical and helpful…

This study tests a program called SONATA that helps older adults (65+) with advanced cancer strengthen their social connections. The goal is to see if it improves emotional, social, and overall quality of life. 70 participants will be randomly assigned to the program or usual car…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in people with advanced cancer. About 30 adults with incurable cancer who are on maintenance treatment will receive the therapy. The …

This study tests whether regular electronic surveys can help people with advanced cancer report their symptoms and needs, so their doctors can connect them to palliative care sooner. About 90 adults with incurable solid tumors will participate. The goal is to see if this simple a…

This study tests a program called BOLSTER designed to help people with advanced gynecologic or gastrointestinal cancers and their caregivers. The program provides extra support for those with complex care needs like ostomies or feeding tubes. Researchers want to see if it improve…

This study tests whether spiritual care interventions can improve spiritual well-being and readiness to plan future medical care in Black patients with advanced cancer. About 64 participants will receive the intervention in outpatient settings. The goal is to see if a larger tria…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce anxiety, depression, and existential distress in people with advanced cancer. About 200 adults with stage 3 or 4 cancer will receive either psiloc…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely ease severe pain in people with advanced cancer that doesn't respond to opioids. Fifteen adults with advanced cancer and persistent pain will receive the treatment and …

This study tests a counseling program called Focused ACT (FACT) to see if it helps reduce anxiety about death in people with advanced cancer. About 70 adults whose cancer has progressed after at least one treatment will participate. The program involves talking with a counselor a…

This study tests a program called ALIGN, which provides virtual palliative care visits for older adults with advanced cancer who are moving from the hospital to a skilled nursing facility. The goal is to see if the program can be delivered successfully and help patients and their…

This study tests whether a care coach-led team can improve quality of life for 770 adults with advanced cancer who are undergoing major surgery. The team includes surgical oncology, rehabilitation, and palliative care specialists working together to address physical, emotional, a…

This study tests a quick, practical health check for people aged 70 and older with advanced cancer. The check helps doctors tailor chemotherapy to reduce harmful side effects. Researchers will also see if step counts and body scans can predict how well patients handle treatment.

This study is observing 50 adults with advanced cancers (lung, breast, colorectal, liver, stomach) who are starting immunotherapy. Researchers will track ctDNA levels in the blood to see if changes can predict early whether the treatment is working. They will also look at other m…

This study is for 400 people with advanced or rare cancers who have not responded to standard treatments. Doctors use each person's tumor gene profile to pick a personalized therapy. The goal is to see if this approach improves tumor shrinkage and helps more patients get targeted…

This study looks at how cancer treatments cause nerve pain. Researchers will use simple sensory tests and small skin samples to understand the pain better. The goal is to learn more, not to treat the pain directly. Adults with advanced cancer who have pain from certain chemothera…

This study tests whether a special clinic that checks your genes and medications can lower the chance of harmful drug interactions. About 1,300 adults with cancer or mental health conditions who take multiple medications will participate. Researchers will compare how well the cli…

This observational study will use SPECT imaging to measure how radiopharmaceutical therapies distribute in the body of 80 patients with advanced prostate or other cancers. The goal is to improve dosing calculations to make treatment safer and more effective. No new drugs are give…

This study aims to create a patient decision aid called TA-DA for people with advanced cancer who have already tried at least two treatments. The tool helps patients prepare for conversations with their doctors about further options. About 155 patients and clinicians will help de…

This study looks at whether special tests can predict which off-guideline drugs (FDA-approved for other cancers but not listed for a patient's specific cancer) will work for people with advanced cancer. About 300 participants will have their tumors tested, and doctors will try a …

This study looks at whether asking people with advanced or metastatic cancer about their financial worries every month can improve their quality of life and reduce stress. About 1,000 adults who are getting cancer treatment that is not meant to cure them will take part. The goal …