ADVANCED CANCER

This early-stage study tests two drugs together—tepotinib and pembrolizumab—in people with advanced non-small cell lung cancer. The goal is to see if adding tepotinib can help pembrolizumab work better, especially in tumors that don't respond well to immunotherapy alone. About 19…

This study tests a combination of drugs (vorinostat plus either sirolimus, everolimus, or temsirolimus) in people with advanced cancer that hasn't responded to standard treatments. The main goal is to find the safest dose and see if the drugs can shrink tumors. Up to 249 particip…

This early-phase study tests a new investigational drug (RP-6306) combined with two standard chemotherapies (carboplatin and paclitaxel) in people with recurrent ovarian or uterine cancer that has a specific genetic change (TP53 mutation). The main goal is to find the safest dose…

This early-phase trial looks at combining two drugs, bevacizumab and temsirolimus, with one of three other cancer drugs to treat advanced cancers that haven't responded to standard treatments. The main goal is to find the safest, highest dose of these combinations. About 278 adul…

This early-stage study tests a new drug that delivers radiation directly to cancer cells that make a protein called CEA. The drug, Ac225-DOTA-M5A, is designed to find and kill these cancer cells while sparing healthy tissue. The study includes up to 20 people with advanced or met…

This early-phase study tests a new drug called AB598, alone or with other treatments, in about 40 people with advanced solid tumors like lung, bladder, or ovarian cancer. The main goal is to check if the drug is safe and tolerable. Participants must have measurable tumors and be …

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This study tests a drug called avelumab in 25 people with advanced penile cancer who cannot have standard chemo or whose cancer got worse after chemo. Avelumab works by blocking a protein that helps tumors hide from the immune system, which may shrink or slow the cancer. The main…

This study tests a new drug, AB801, alone or with other treatments, in about 91 people with advanced cancers like lung, colon, or breast cancer that have not responded to standard therapies. The main goal is to check the drug's safety and find the best dose. This is an early-phas…

This study tests a new drug called TST001, an antibody that targets a protein (CLDN18.2) found on some cancer cells. It is for people with advanced solid tumors, including stomach, gastroesophageal junction, and pancreatic cancers. The trial aims to find safe doses and see how we…

This early-stage study tests two experimental drugs (botensilimab and balstilimab) that help the immune system fight cancer. It includes about 500 adults with advanced solid tumors like lung, ovarian, or colorectal cancer that haven't responded to standard treatments. The main go…

This study tests whether giving the drug lenvatinib before surgery can help doctors more completely remove advanced thyroid cancer that has spread outside the gland. About 30 adults with this type of cancer will receive lenvatinib for a short time before their operation. The goal…

This study tests whether adding ramucirumab to the standard drug osimertinib can help people with a specific type of advanced lung cancer (EGFR-mutant) live longer without their disease getting worse. About 160 adults with advanced or metastatic non-small cell lung cancer that ha…

This study tests a new way to treat advanced stage IV cancers that have not responded to standard treatments. It uses high doses of a radioactive sugar called FDG, which is taken up by cancer cells and may kill them from the inside. The study involves 30 adults and aims to check …

This phase 2 study tested whether combining an experimental vaccine (DPX-Survivac) with an immunotherapy drug (pembrolizumab) and low-dose chemotherapy can shrink tumors in people with advanced ovarian, fallopian tube, or peritoneal cancer. The vaccine trains the immune system to…

This study tests a drug called adagrasib (MRTX849) in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe, how the body processes it, and whether it can shrink tumors. About 731 participants with various cancers (e.g.,…

This early-phase study tests a new drug called DS-1055a in about 40 adults with advanced solid tumors (like head and neck, stomach, or lung cancer) that have not responded to standard treatments. The main goal is to check the drug's safety and find the right dose. Participants re…

This study tests two different doses of the targeted drug adagrasib in 200 adults with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants have already tried chemotherapy and immunotherapy. The goal is to see which dose works bett…

This study looks at whether support from a community health worker can help African American patients with advanced cancer feel better and plan their care. About 160 patients will either get standard care or extra help from a health worker. The goal is to see if this support impr…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life while coping with their illness. Researchers will interview and test the adapted …

This study looks at whether draining fluid from the chest every day helps people with advanced cancer breathe better compared to draining it three times a week. About 257 adults with cancer-related fluid buildup around the lungs will use a small tube at home to drain the fluid. T…

This study tests whether a single high dose of psilocybin (the active ingredient in magic mushrooms), combined with talk therapy, can help people with advanced cancer feel less anxious about death and dying. Fifteen adults with stage IV cancer will receive the treatment and be mo…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who are losing weight. About 98 patients will receive either mirtazapine or a placebo for 15 to 29 days. The goal is to see if it helps with appetite, sl…

This study tests whether a mobile app called SUPPORT+ can help adults with advanced cancer who are receiving palliative care feel better and stay out of the hospital. Participants use the app to report symptoms weekly, get self-care tips, and receive nurse follow-up for severe is…

This study looks at whether a new care planning method, called ABC123, is practical and acceptable for people over 60 with advanced, incurable cancer. About 70 participants will try the framework during their first doctor visit and be followed for 6 months. The goal is to see if …

This study is testing a new telehealth program called CASA, designed to help people with advanced cancer and their caregivers cope better. The program involves five 60-minute online sessions. The goal is to see if it improves spiritual well-being and reduces depression and anxiet…

This study looks at whether a special decision-making tool can help doctors and patients with advanced non-small cell lung cancer choose more wisely about continuing or stopping cancer treatments. The goal is to see if using this tool reduces the number of patients receiving aggr…

This study tests whether artificial intelligence (AI) can accurately summarize conversations between doctors and patients with advanced cancer about their care goals. About 60 patients from Dana-Farber Cancer Institute will have their serious illness talks summarized by an AI pro…