ADVANCED CANCER

This study tested a personalized vaccine made for each patient's unique cancer. It included 25 adults with advanced solid tumors who had no other treatment options. The goal was to see if making and giving the vaccine was safe and possible.

This early-phase study tested an experimental drug called PTX-100 in 25 people with advanced cancers (like multiple myeloma, lymphoma, and certain solid tumors) that had stopped responding to standard treatments. The goal was to find the safest dose and understand how the drug wo…

This study tested an experimental drug called BMS-986288, given alone or with another drug (nivolumab), in 219 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. Researchers also looked …

This study tested a new drug called RP-6306 in 28 people with advanced cancer that could not be cured. The goal was to see if the drug is safe and helps shrink tumors when given with standard treatments. Researchers also checked if certain biomarkers made the drug work better. Th…

This early-phase study tested the safety of combining multiple cancer drugs (niraparib, TSR-022, bevacizumab, chemotherapy, and TSR-042) in 60 adults with advanced or metastatic solid tumors, including lung cancer. The goal was to find safe doses for future larger studies. The tr…

This early-stage trial tested a new drug, NEV801, in 78 adults with advanced solid tumors that no longer responded to standard treatments. The main goal was to find the safest dose and check for any side effects. Researchers also looked for signs that the drug might shrink tumors…

This early-phase trial tested an experimental pill called ART4215 in 93 people with advanced or metastatic solid tumors (including breast cancer). The main goals were to find a safe dose and check for side effects when given alone or with other cancer drugs. The study is now comp…

This early-stage study tested a new drug called COM902, alone or with another drug (COM701), in 94 people with advanced cancers like ovarian, lung, or colon cancer. The main goals were to check safety, find the best dose, and see if the drugs help control the disease. Participant…

This study tested whether the immunotherapy drug nivolumab can help prevent esophageal cancer from coming back after surgery. About 794 people who had surgery for stage II or III cancer received either nivolumab or a placebo. The main goal was to see if nivolumab lengthened the t…

This early-phase study tested a new experimental drug called BMS-986249, both by itself and together with the immunotherapy nivolumab, in 356 adults with advanced solid tumors (cancers that have spread or cannot be removed). The main goal was to check safety and find the right do…

This study tested a combination of two drugs, lenvatinib and eribulin, in 30 adults with advanced sarcoma (a type of cancer) that could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them from growing. The drugs work by cutting off t…

This study tested a combination of three drugs (relatlimab, nivolumab, and either BMS-986205 or ipilimumab) in 229 people with advanced solid tumors that could not be cured. The goal was to see if the triple therapy was safe and could shrink or control the cancer. Participants ha…

This study tested whether adding the oral drug axitinib to the standard treatment sandostatin LAR could slow cancer growth in people with advanced neuroendocrine tumors that started outside the pancreas. 256 adults with tumors that had recently grown were randomly assigned to get…

This early-stage study tested an experimental oral drug called Q702 in 51 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects, while also looking for signs that the drug might shr…

This early-phase study tested a new drug called AGEN1777, alone or with another drug (a PD-1 inhibitor), in 25 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. The study is now complet…

This early-phase study tested a new drug called MRX-2843 in 42 adults with advanced or metastatic solid tumors that had not responded to prior treatments. The main goal was to check the drug's safety and find the best dose. Researchers monitored side effects and how the drug move…

This early-phase trial tested whether adding the drug pirfenidone to standard chemotherapy is safe and effective for people with advanced non-small cell lung cancer. 48 participants received the combination to find the best dose and see if tumors shrank. The goal was to control t…

This study tested a combination of two immunotherapy drugs, nivolumab and relatlimab, in 68 adults with advanced soft-tissue sarcoma. The goal was to see if the combo could shrink tumors or stop them from growing for at least 6 months. Participants had a specific immune feature i…

This study tested a program called CONTINUUM for people with advanced cancer leaving the hospital. Within three days of going home, patients had a video visit with a specialized nurse to support their transition. The goal was to see if this extra support helps patients feel more …

This study tested a program to help couples communicate better when one partner has advanced cancer. About 440 patients and their partners took part, with half receiving communication training and the other half getting general healthy living information. The goal was to see if t…

This study looked at 1,250 adults with advanced cancer who visited the emergency room. Researchers checked medical records to find factors linked to survival in the next 90 days. The goal is to help doctors identify patients who need extra support or palliative care sooner.

This study looked at how patients with advanced cancer respond to being offered a chance to discuss and write down their wishes for end-of-life care. Researchers followed 71 patients to see who took up the offer and how it affected their care. The goal is to improve how doctors a…

This study looked at 42 adults with advanced solid tumors who were already on or about to start immunotherapy (checkpoint inhibitors) and also needed palliative radiotherapy to ease symptoms like pain or breathing trouble. The goal was to see how safe the combination is and wheth…