New drug combo shows promise in advanced cancers – early trial results

NCT ID NCT03369223

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 18, 2025 · Last updated May 20, 2026 · Updated 23 times

Summary

This early-phase study tested a new experimental drug called BMS-986249, both by itself and together with the immunotherapy nivolumab, in 356 adults with advanced solid tumors (cancers that have spread or cannot be removed). The main goal was to check safety and find the right dose. Researchers also looked at whether the tumors shrank. This is not a cure, but a step toward better control of advanced cancers.

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Contacts and locations

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Locations

Local Institution - 0001

Hackensack, New Jersey, 07601, United States
Local Institution - 0002

New York, New York, 10032, United States
Local Institution - 0003

New York, New York, 10065, United States
Local Institution - 0004

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0005

Aurora, Colorado, 80045, United States
Local Institution - 0006

Denver, Colorado, 80218, United States
Local Institution - 0007

Norfolk, Virginia, 23502, United States
Local Institution - 0008

Greenville, South Carolina, 29605, United States
Local Institution - 0009

Dallas, Texas, 75246, United States
Local Institution - 0010

Austin, Texas, 78705-1165, United States
Local Institution - 0011

Tyler, Texas, 75702, United States
Local Institution - 0012

Leesburg, Virginia, 20176, United States
Local Institution - 0013

Eugene, Oregon, 97401, United States
Local Institution - 0014

Adelaide, South Australia, 5000, Australia
Local Institution - 0015

North Sydney, New South Wales, 2060, Australia
Local Institution - 0016

San Antonio, Texas, 78240, United States
Local Institution - 0017

Miami, Florida, 33176, United States
Local Institution - 0018

Vancouver, Washington, 98684, United States
Local Institution - 0020

Naples, 80131, Italy
Local Institution - 0021

Houston, Texas, 77030, United States
Local Institution - 0022

Madrid, Madrid, Comunidad de, 28027, Spain
Local Institution - 0023

Madrid, 28040, Spain
Local Institution - 0024

Baltimore, Maryland, 21287, United States
Local Institution - 0025

Frankston, Victoria, 3199, Australia
Local Institution - 0026

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 0029

Cincinnati, Ohio, 45219, United States
Local Institution - 0030

Essen, 45147, Germany
Local Institution - 0031

Heidelberg, 69120, Germany
Local Institution - 0035

Hamburg, 20251, Germany
Local Institution - 0036

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0037

Buenos Aires, C1426ANZ, Argentina
Local Institution - 0038

Buenos Aires, Distrito Federal, 1121, Argentina
Local Institution - 0039

Helsinki, 00029, Finland
Local Institution - 0040

Warsaw, 02-781, Poland
Local Institution - 0041

Craiova, 200542, Romania
Local Institution - 0042

Badalona, Barcelona [Barcelona], 08916, Spain
Local Institution - 0043

Málaga, 29010, Spain
Local Institution - 0044

Barcelona, 08035, Spain
Local Institution - 0045

Bucharest, 022328, Romania
Local Institution - 0047

Heidelberg, Victoria, 3084, Australia
Local Institution - 0048

Milan, 20133, Italy
Local Institution - 0049

Siena, 53100, Italy
Local Institution - 0050

Madrid, 28041, Spain
Local Institution - 0052

CABA, Distrito Federal, C1430, Argentina
Local Institution - 0056

Ottawa, Ontario, K1H 8L6, Canada

Conditions

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ADVANCED CANCER