Advanced cancer

This early-stage trial tests a new oral drug called TQB3217 in 40 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see how the body processes the drug. Researchers will also look for any…

This study tests a new drug called TST001 added to standard chemotherapy and immunotherapy for people with advanced stomach or gastroesophageal junction cancer that has not been treated before. The goal is to see if the combination helps control the tumor longer and improves surv…

This study is for people with advanced biliary tract cancer whose disease is stable after initial chemotherapy plus immunotherapy. It compares four different maintenance treatments: immunotherapy alone or combined with lenvatinib, venadaparib, or interleukin-2. The goal is to fin…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

Researchers at Dana-Farber Cancer Institute are testing Healing Gardens, a mobile game that delivers pain-focused cognitive behavioral therapy and cancer pain education. The study enrolls 46 adults with advanced solid tumors who have chronic pain related to cancer or its treatmen…

Researchers are testing whether a single high dose of psilocybin, given alongside a structured talking therapy called PEARL, reduces depressive symptoms in adults with advanced cancer. The trial enrolls 46 people in Ontario with stage IV solid tumors, sarcoma, melanoma, endocrine…

This pilot trial tests whether psilocybin-assisted therapy can help adults with advanced cancer who feel demoralized, hopeless, or distressed about their illness. Participants receive a single dose of psilocybin (either 25 mg or 5 mg) during a group session, paired with either mi…

This pilot trial tests a program called FamilyStrong, designed to help family caregivers of people with advanced cancer manage their own distress. Caregivers receive monthly phone calls from a trained lay navigator who screens for stress, identifies their biggest concerns, and of…

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer keep track of their pain and medications. About 73 participants will use the app and rate how easy it is to use and how helpful it is. The goal is to see if the app can make managing canc…

This study tests whether a special glass-based bone cement, used with ultrasound during surgery, can safely stabilize bones and reduce pain in people with advanced cancer that has spread to the pelvis. Eight adults aged 18 to 80 with painful pelvic bone tumors will receive the tr…

This study tests a death education program for family caregivers of people with advanced cancer. The program includes four one-on-one sessions to help caregivers communicate about death, reduce anxiety and depression, and improve spiritual well-being. About 30 caregivers will tak…

This observational study aims to understand how symptoms like pain, fatigue, and nausea change over time in children with advanced cancer. Researchers will ask children aged 8 to 18 and their caregivers to complete surveys about symptoms and overall health. The goal is to identif…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…