Respiratory tract infectious disorder

Researchers are testing six different formulations of a cell culture-derived H2N3 influenza vaccine in about 600 healthy adults aged 18 and older. Participants receive two injections three weeks apart and are followed for about a year. The study measures antibody levels and check…

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study tested a booster vaccine for H5N6 bird flu in about 260 adults. Some had previously received an H5N1 bird flu vaccine, while others had not. The goal was to see if the booster was safe and triggered a strong immune response. Participants received one or two doses of th…

This study tested whether a vaccine called VPM1002 could help healthcare workers miss fewer days of work due to respiratory illnesses, including COVID-19. About 1,200 doctors, nurses, and other hospital staff received either the vaccine or a placebo. The goal was to see if the va…

This completed study in Japan checked the safety of the RSV vaccine Abrysvo in 497 pregnant women and their infants. Researchers tracked side effects in mothers for 28 days after vaccination and in babies from birth to 28 days old. The goal was to confirm the vaccine's safety in …

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study tested an RSV vaccine in 378 older adults (60+) in Korea to see if it is safe and helps the body fight the virus. Participants received either the vaccine or a placebo and were monitored for side effects and immune response. The results showed the vaccine was well tole…

This study tested a new COVID-19 booster vaccine called SpiN-Tec in 432 healthy adults aged 18 to 85 who had already received full vaccination and at least one booster. The vaccine was compared to approved boosters like Covishield and Comirnaty. The goal was to check safety and w…

This study tested an inhaled drug called RSP-1502, which combines the antibiotic tobramycin with a substance called CaEDTA, in 71 people with cystic fibrosis who have chronic Pseudomonas lung infections. The goal was to check safety and find the right dose. Participants received …

This study tested whether a dietary supplement called Imunoglukan P4H® (made from pleuran, a mushroom extract, plus vitamin C) could help people with chronic sinusitis. 85 patients over age 12 took the supplement alongside standard treatments like nasal sprays and saline rinses. …

This study tested whether a daily probiotic drink (like Yakult) can reduce cold symptoms in triathletes before and after a competition. 80 healthy amateur triathletes drank either the probiotic or a placebo for 30 days before and 14 days after a race. Researchers tracked symptoms…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…

This study tested whether adding a procedure called fiberoptic bronchoscopy to standard care helps adults with severe ventilator-associated pneumonia. One hundred patients were split into two groups: one got usual treatment (antibiotics, suctioning), the other got the same plus d…

This study is testing new rapid tests (lateral flow and microfluidic devices) to detect respiratory infections in children and adults in Uganda, Ethiopia, and Senegal. Researchers want to see if these tests are accurate and easy to use in low-resource clinics. Participants with r…

This study is testing a new diagnostic panel called the BioFire ECoV Panel, designed to detect coronaviruses from leftover nose swab samples. Researchers will enroll 1,500 people and compare the panel's results to standard tests to see how accurate it is. The test is not being us…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study looked at whether FebriDx, a rapid fingerstick test, can accurately tell bacterial from non-bacterial acute respiratory infections when used by people without lab training. Researchers compared results from untrained operators to trained ones in 800 patients with fever…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This study tested whether treating private well water with ultraviolet (UV) light can prevent stomach and respiratory infections in children under 5. Researchers gave 28 Pennsylvania households either a real UV device or a fake one and tracked illness symptoms via weekly texts. T…

This study tested whether special UV light devices placed in common areas of nursing homes can reduce the number of severe respiratory infections (like pneumonia or COVID-19) in elderly residents. Over 1,600 residents in 12 French nursing homes took part. The devices were either …

This study tested whether a bacterial lysate (Broncho Vaxom) can prevent wheezing in infants who were hospitalized for severe bronchiolitis. 173 infants received either the lysate or a placebo for up to 24 months. The goal was to see if the treatment reduces the number of wheeze …

This study tested whether specially built houses (Star Homes) could reduce malaria, respiratory infections, and diarrhea in children under 13 in rural Tanzania. Over 1,100 children lived either in a Star Home or a traditional mud house. The Star Homes have screened windows, solar…

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This study tested whether a daily probiotic called LC-Plasma can prevent upper respiratory tract infections (like colds) in healthy adults aged 18-60 who often get sick. Over 600 participants took either the probiotic or a placebo pill every day for 24 weeks. Researchers tracked …

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,200 adults who had already received at least two mRNA vaccine doses were randomly assigned to get either the Novavax or P…

Researchers are testing whether adjusting a patient's body position based on where the lung infection sits, combined with mechanical vibration on the chest, helps clear infected mucus better than routine position changes. The trial enrolls 384 adults in intensive care who need a …

This trial tests whether two nasal pump sprays made from diluted seawater can safely ease symptoms of colds, rhinitis, sinusitis, and other upper respiratory infections. Participants, from 3 months old, will use one of the sprays for 7 days while doctors track symptom severity an…

This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older wi…

This pilot study tested whether adding a vibrating chest vest to a standard cough-assist machine could reduce lung infections and hospital stays in people with ALS who use breathing support. Fourteen patients were randomly assigned to use either the vest plus cough assist or the …

This study tested four different nasal aspirators (including electric and manual types) in 28 infants with colds. Caregivers rated how easy each device was to use and how it affected their baby's sleep, feeding, and breathing. The goal was to find which device parents prefer and …

This study tested a new device called the COMBO Endoscopy Oropharyngeal Airway in 104 adults undergoing a sedated lung procedure (fiberoptic bronchoscopy). The device combines oxygen delivery, airway support, and breathing monitoring into one tool. The goal was to see if it could…

This completed trial tested three common cough treatments—levodropropizine, a codeine combination, and ivy leaf extract—against a placebo in 196 adults with acute cough from upper respiratory infections. Participants took the medicine three times a day for four days. The main goa…

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study investigates whether zinc oxide nanoparticles can inhibit the growth and biofilm formation of Acinetobacter baumannii, a bacterium that causes severe hospital-acquired infections like pneumonia and bloodstream infections. Researchers will collect samples from 150 patie…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study tested whether a short animated video program could help first-graders learn how to prevent respiratory infections like colds. Forty-eight children in Turkey watched a 15-minute cartoon and practiced handwashing and coughing/sneezing etiquette over three weeks. Researc…

This study tracked 241 ICU patients with severe influenza to see how many developed a fungal lung infection called IAPA. Researchers collected blood and fluid samples to identify risk factors. The goal is to help doctors spot high-risk patients earlier.

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This study looked at how the immune system of healthy adults aged 65-75 responds to RSV, a common cause of chest infections. Researchers gave volunteers a mild RSV infection and took blood and nose samples to find immune markers linked to protection. The goal is to use these find…

This study looked at how the COVID-19 pandemic and related public health measures changed asthma control in children aged 3 to 16. Researchers compared asthma control and flare-ups in 577 children during the pandemic to data from before the pandemic. The goal was to see if lockdo…

This study checked how accurate a new test (Xpert Expanded Respiratory Panel) is at finding respiratory infections. Researchers tested nose swabs from 3,200 people with symptoms and compared results to other tests. The goal was to see if the new test works well enough for routine…

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study gave healthy adults a mild dose of respiratory syncytial virus (RSV) in a controlled hospital setting to learn how the body fights the infection. Thirty-two volunteers aged 18 to 50 stayed in isolation for about 10 days while researchers monitored symptoms, viral shedd…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study looked at 760 children under 8 years old who had surgery with a breathing tube. Some had cold symptoms, others did not. Researchers tested five simple signs—like facial grimace and eye opening—to see if they could predict a safe breathing tube removal. The goal was to …

This study tested a computer tool that helps nurses decide when antibiotics are needed for common respiratory infections like colds and sore throats. The tool, built into the electronic health record, calculates a patient's risk and suggests appropriate care. Researchers measured…

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to…

This study tested whether inhaling iloprost, a drug that widens blood vessels in the lungs, can improve oxygen levels in obese patients during one-lung ventilation for lung surgery. 78 participants were randomly assigned to receive either iloprost or a saltwater placebo. The rese…

This study looked at over 2,300 children aged 0-12 who had mild cold symptoms before elective non-cardiac surgery. Researchers wanted to see if the COVID-19 pandemic changed the risks of complications like breathing problems or infections. The goal is to help doctors decide the s…

This pilot study tested a noninvasive wearable device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen for and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks w…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…